The DOI matches its Crossref record.
Abyssomicin C—A Polycyclic Antibiotic from a Marine Verrucosispora Strain as an Inhibitor of the p ‐Aminobenzoic Acid/Tetrahydrofolate Biosynthesis Pathway
Abstract
Plumbing the depths: Abyssomicin C (structure shown) from ocean floor sediment is a novel antibiotic that inhibits the biosynthesis steps between chorismate and p-aminobenzoic acid. Its activity may be explained by the irreversible trapping of the targeted enzymes by a Michael addition. Blocking the biosynthesis of p-aminobenzoic acid may be one approach to developing new antibiotics.
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Citations
Cited by
Discovery of novel metabolites from marine actinomycetes
Lam, K. S. (2006) · Current Opinion in Microbiology · doi:10.1016/j.mib.2006.03.004 · Cited by 539
Combating Multidrug‐Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials
O'Connell, K. M. G., Hodgkinson, J. T., Sore, H. F., Welch, M., Salmond, G. P. C., & Spring, D. R. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201209979 · Cited by 435
Metadata
- Authors
- Bister, B., Bischoff, D., Ströbele, M., Riedlinger, J., Reicke, A., Wolter, F., Bull, A. T., Zähner, H., Fiedler, H., & Süssmuth, R. D.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2004-04-28
- Volume
- 43
- Issue
- 19
- Pages
- 2574-2576
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2091874125
- Cited by
- 309
- References
- 0
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Abyssomicin C—A Polycyclic Antibiotic from a Marine Verrucosispora Strain as an Inhibitor of the p ‐Aminobenzoic Acid/Tetrahydrofolate Biosynthesis Pathway. https://app.cochat.ai/papers/10.1002/anie.200353160
- The paper
- Bister, B., Bischoff, D., Ströbele, M., Riedlinger, J., Reicke, A., Wolter, F., Bull, A. T., Zähner, H., Fiedler, H., & Süssmuth, R. D. (2004). Abyssomicin C—A Polycyclic Antibiotic from a Marine Verrucosispora Strain as an Inhibitor of the p ‐Aminobenzoic Acid/Tetrahydrofolate Biosynthesis Pathway. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200353160
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
