Discovery of novel metabolites from marine actinomycetes
Abstract
Recent findings from culture-dependent and culture-independent methods have demonstrated that indigenous marine actinomycetes exist in the oceans and are widely distributed in different marine ecosystems. There is tremendous diversity and novelty among the marine actinomycetes present in marine environments. Progress has been made to isolate novel actinomycetes from samples collected at different marine environments and habitats. These marine actinomycetes produce different types of new secondary metabolites. Many of these metabolites possess biological activities and have the potential to be developed as therapeutic agents. Marine actinomycetes are a prolific but underexploited source for the discovery of novel secondary metabolites.
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Faulkner, D. J. (1990) · Natural Product Reports · doi:10.1039/np9900700269 · Cited by 4,880 · see citing works
Prokaryotes: The unseen majority
Whitman, W. B., Coleman, D. C., & Wiebe, W. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6578 · Cited by 4,871 · see citing works
Bioactive Microbial Metabolites: A Personal View
Bérdy, J. (2005) · The Journal of Antibiotics · doi:10.1038/ja.2005.1 · Cited by 3,170 · see citing works
Characteristics, dynamics and significance of marine snow
Alldredge, A. L., & Silver, M. W. (1988) · Progress In Oceanography · doi:10.1016/0079-6611(88)90053-5 · Cited by 1,424 · see citing works
Isolating "Uncultivable" Microorganisms in Pure Culture in a Simulated Natural Environment
Kaeberlein, T., Lewis, K., & Epstein, S. S. (2002) · Science · doi:10.1126/science.1070633 · Cited by 1,239 · see citing works
Feling, R. H., Buchanan, G. O., Mincer, T. J., Kauffman, C. A., Jensen, P. R., & Fenical, W. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200390115 · Cited by 1,057 · see citing works
Zengler, K., Toledo, G., Rappé, M., Elkins, J., Mathur, E. J., Short, J. M., & Keller, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252630999 · Cited by 796 · see citing works
Drugs from the deep: Marine natural products as drug candidates
Haefner, B. (2003) · Drug Discovery Today · doi:10.1016/s1359-6446(03)02713-2 · Cited by 740 · see citing works
Molecular Evidence for a Uniform Microbial Community in Sponges from Different Oceans
Hentschel, U., Hopke, J. N., Horn, M., Friedrich, A. B., Wagner, M., Hacker, J. H., & Moore, B. S. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.9.4431-4440.2002 · Cited by 703 · see citing works
Chauhan, D., Catley, L., Li, G., Podar, K., Hideshima, T., Velankar, M., Mitsiades, C., Mitsiades, N., Yasui, H., Letai, A., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.10.013 · Cited by 694 · see citing works
Anticancer Agents from Natural Products
Cragg, G. M. L., Kingston, D. G. I., & Newman, D. J. (2005) · CRC Press eBooks · doi:10.1201/9781420039658 · Cited by 639 · see citing works
Widespread and Persistent Populations of a Major New Marine Actinomycete Taxon in Ocean Sediments
Mincer, T. J., Jensen, P. R., Kauffman, C. A., & Fenical, W. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.10.5005-5011.2002 · Cited by 583 · see citing works
Search and Discovery Strategies for Biotechnology: the Paradigm Shift
Bull, A. T., Ward, A. C., & Goodfellow, M. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.3.573-606.2000 · Cited by 476 · see citing works
Inagaki, F., Suzuki, M., Takai, K., Oida, H., Sakamoto, T., Aoki, K., Nealson, K. H., & Horikoshi, K. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.12.7224-7235.2003 · Cited by 443 · see citing works
Marine natural products and their potential applications as anti-infective agents
Donia, M., & Hamann, M. T. (2003) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00655-8 · Cited by 425 · see citing works
Blunt, J. W., Copp, B. R., Munro, M. H. G., Northcote, P. T., & Prinsep, M. R. (2006) · Natural Product Reports · doi:10.1039/b502792f · Cited by 418 · see citing works
Microbial Diversity and Bioprospecting
(2003) · ASM Press eBooks · doi:10.1128/9781555817770 · Cited by 401 · see citing works
Blunt, J. W., Copp, B. R., Munro, M. H. G., Northcote, P. T., & Prinsep, M. R. (2005) · Natural Product Reports · doi:10.1039/b415080p · Cited by 350 · see citing works
Phylogenetic Diversity of Bacteria Associated with the Marine Sponge Rhopaloeides odorabile
Webster, N. S., Wilson, K. J., Blackall, L. L., & Hill, R. T. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.1.434-444.2001 · Cited by 346 · see citing works
New primers for the class Actinobacteria : application to marine and terrestrial environments
Stach, J. E. M., Maldonado, L. A., Ward, A. C., et al. (2003) · Environmental Microbiology · doi:10.1046/j.1462-2920.2003.00483.x · Cited by 331 · see citing works
Marine actinomycete diversity and natural product discovery
Jensen, P. R., Mincer, T. J., Williams, P. G., et al. (2005) · Antonie van Leeuwenhoek · doi:10.1007/s10482-004-6540-1 · Cited by 326 · see citing works
Actinomycetes in Biotechnology
(1988) · Elsevier eBooks · doi:10.1016/c2009-0-02828-1 · Cited by 321 · see citing works
Maldonado, L. A., Fenical, W., Jensen, P. R., Kauffman, C. A., Mincer, T. J., Ward, A. C., Bull, A. T., & Goodfellow, M. (2005) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.63625-0 · Cited by 317 · see citing works
Culturable marine actinomycete diversity from tropical Pacific Ocean sediments
Jensen, P. R., Gontang, E. A., Mafnas, C., et al. (2005) · Environmental Microbiology · doi:10.1111/j.1462-2920.2005.00785.x · Cited by 311 · see citing works
Bister, B., Bischoff, D., Ströbele, M., et al. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200353160 · Cited by 309 · see citing works
Distribution of actinomycetes in near-shore tropical marine sediments
Jensen, P. R., Dwight, R., & Fenical, W. (1991) · Applied and Environmental Microbiology · doi:10.1128/aem.57.4.1102-1108.1991 · Cited by 303 · see citing works
Blunt, J. W., Copp, B. R., Munro, M. H. G., Northcote, P. T., & Prinsep, M. R. (2004) · Natural Product Reports · doi:10.1039/b305250h · Cited by 298 · see citing works
Riedlinger, J., Reicke, A., Zähner, H., Krismer, B., Bull, A. T., Maldonado, L. A., Ward, A. C., Goodfellow, M., Bister, B., Bischoff, D., et al. (2004) · The Journal of Antibiotics · doi:10.7164/antibiotics.57.271 · Cited by 295 · see citing works
Kwon, H. C., Kauffman, C. A., Jensen, P. R., & Fenical, W. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0558948 · Cited by 294 · see citing works
Biological, Biochemical, and Biomedical Aspects of Actinomycetes
(1984) · Elsevier eBooks · doi:10.1016/c2013-0-11265-2 · Cited by 287 · see citing works
Magarvey, N. A., Keller, J. M., Bernan, V. S., et al. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.12.7520-7529.2004 · Cited by 278 · see citing works
Marine actinomycetes as a source of novel secondary metabolites
Fiedler, H., Bruntner, C., Bull, A. T., Ward, A. C., Goodfellow, M., Potterat, O., Puder, C., & Mihm, G. (2005) · Antonie van Leeuwenhoek · doi:10.1007/s10482-004-6538-8 · Cited by 264 · see citing works
Microbial Communities from Methane Hydrate-Bearing Deep Marine Sediments in a Forearc Basin
Reed, D. W., Fujita, Y., Delwiche, M. E., et al. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.8.3759-3770.2002 · Cited by 258 · see citing works
Bacteria and Archaea Physically Associated with Gulf of Mexico Gas Hydrates
Lanoil, B., Sassen, R., Duc, M. T. L., et al. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.11.5143-5153.2001 · Cited by 238 · see citing works
Marine actinobacteria: perspectives, challenges, future directions
Bull, A. T., Stach, J. E. M., Ward, A. C., & Goodfellow, M. (2005) · Antonie van Leeuwenhoek · doi:10.1007/s10482-004-6562-8 · Cited by 232 · see citing works
Diversity of cultivable actinobacteria in geographically widespread marine sediments
Maldonado, L. A., Stach, J. E. M., ., W. P.-A., Ward, A. C., Bull, A. T., & Goodfellow, M. (2005) · Antonie van Leeuwenhoek · doi:10.1007/s10482-004-6525-0 · Cited by 199 · see citing works
Natural products as immunosuppressive agents
Mann, J. (2001) · Natural Product Reports · doi:10.1039/b001720p · Cited by 192 · see citing works
Diazepinomicin, a New Antimicrobial Alkaloid from a Marine Micromonospora sp.
Charan, R. D., Schlingmann, G., Janso, J. E., et al. (2004) · Journal of Natural Products · doi:10.1021/np040042r · Cited by 184 · see citing works
ACTINOMYCETES IN MARINE SEDIMENTS
Goodfellow, M., & Haynes, J. A. (1984) · Elsevier eBooks · doi:10.1016/b978-0-12-528620-6.50039-2 · Cited by 180 · see citing works
Antagonistic activity of bacteria isolated from organic aggregates of the German Wadden Sea
Grossart, H., Schlingloff, A., Bernhard, M., et al. (2004) · FEMS Microbiology Ecology · doi:10.1016/s0168-6496(03)00305-2 · Cited by 164 · see citing works
Antibiotic Terpenoid Chloro-Dihydroquinones from a New Marine Actinomycete
Soria-Mercado, I. E., Prieto‐Davó, A., Jensen, P. R., & Fenical, W. (2005) · Journal of Natural Products · doi:10.1021/np058011z · Cited by 161 · see citing works
MASKEY, R. P., HELMKE, E., KAYSER, O., FIEBIG, H. H., MAIER, A., BUSCHE, A., & LAATSCH, H. (2004) · The Journal of Antibiotics · doi:10.7164/antibiotics.57.771 · Cited by 158 · see citing works
Buchanan, G. O., Williams, P. G., Feling, R. H., Kauffman, C. A., Jensen, P. R., & Fenical, W. (2005) · Organic Letters · doi:10.1021/ol050901i · Cited by 150 · see citing works
Maskey, R. P., Li, F., Qin, S., Fiebig, H., & Laatsch, H. (2003) · The Journal of Antibiotics · doi:10.7164/antibiotics.56.622 · Cited by 149 · see citing works
Mechercharmycins A and B, Cytotoxic Substances from Marine-derived Thermoactinomyces sp. YM3-251
Kanoh, K., Matsuo, Y., Adachi, K., Imagawa, H., Nishizawa, M., & Shizuri, Y. (2005) · The Journal of Antibiotics · doi:10.1038/ja.2005.36 · Cited by 139 · see citing works
Kim, T. K., Garson, M. J., & Fuerst, J. A. (2005) · Environmental Microbiology · doi:10.1111/j.1462-2920.2005.00716.x · Cited by 137 · see citing works
CROSS, T. (1981) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1981.tb04245.x · Cited by 136 · see citing works
Mincer, T. J., Fenical, W., & Jensen, P. R. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.11.7019-7028.2005 · Cited by 135 · see citing works
Manam, R. R., Teisan, S., White, D. J., Nicholson, B., Grodberg, J., Neuteboom, S., Lam, K. S., Mosca, D. A., Lloyd, G. K., & Potts, B. C. M. (2005) · Journal of Natural Products · doi:10.1021/np049725x · Cited by 133 · see citing works
Self-citationRhodococcus marinonascens sp. nov., an Actinomycete from the Sea
Helmke, E., & WEYLAND, H. (1984) · International Journal of Systematic Bacteriology · doi:10.1099/00207713-34-2-127 · Cited by 131 · see citing works
Macherla, V. R., Liu, J., Bellows, C., et al. (2005) · Journal of Natural Products · doi:10.1021/np049597c · Cited by 131 · see citing works
Moran, M. A., Rutherford, L. D., & Hodson, R. E. (1995) · Applied and Environmental Microbiology · doi:10.1128/aem.61.10.3695-3700.1995 · Cited by 130 · see citing works
Li, F., Maskey, R. P., Qin, S., Sattler, I., Fiebig, H., Maier, A., Zeeck, A., & Laatsch, H. (2005) · Journal of Natural Products · doi:10.1021/np030518r · Cited by 117 · see citing works
Oldfield, C., Wood, N. T., Gilbert, S. C., et al. (1998) · Antonie van Leeuwenhoek · doi:10.1023/a:1001724516342 · Cited by 115 · see citing works
Microbes from Marine Sponges: A Treasure Trove of Biodiversity for Natural Products Discovery
Hill, R. T. (2014) · ASM Press eBooks · doi:10.1128/9781555817770.ch18 · Cited by 114 · see citing works
Helquinoline, a New Tetrahydroquinoline Antibiotic from Janibacter limosus Hel 1.
Asolkar, R. N., Schröder, D., Heckmann, R., et al. (2004) · The Journal of Antibiotics · doi:10.7164/antibiotics.57.17 · Cited by 108 · see citing works
Mitchell, S. S., Nicholson, B., Teisan, S., Lam, K. S., & Potts, B. C. M. (2004) · Journal of Natural Products · doi:10.1021/np049970g · Cited by 107 · see citing works
Self-citationMaskey, R. P., Helmke, E., & Laatsch, H. (2003) · The Journal of Antibiotics · doi:10.7164/antibiotics.56.942 · Cited by 105 · see citing works
A review of the gas hydrates, geology, and biology of the Nankai Trough
Colwell, F. S., Matsumoto, R., & Reed, D. W. (2004) · Chemical Geology · doi:10.1016/j.chemgeo.2003.12.023 · Cited by 98 · see citing works
Bruntner, C., Binder, T., ., W. P.-A., et al. (2005) · The Journal of Antibiotics · doi:10.1038/ja.2005.43 · Cited by 96 · see citing works
Schumacher, R. W., Talmage, S. C., Miller, S. A., et al. (2003) · Journal of Natural Products · doi:10.1021/np020594e · Cited by 82 · see citing works
Novel Caprolactones from a Marine Streptomycete
Stritzke, K., Schulz, S., Laatsch, H., et al. (2004) · Journal of Natural Products · doi:10.1021/np030321z · Cited by 76 · see citing works
Synthesis of the Fully Functionalized Core Structure of the Antibiotic Abyssomicin C
Rath, J., Kinast, S., & Maier, M. E. (2005) · Organic Letters · doi:10.1021/ol0511068 · Cited by 72 · see citing works
Improved Recoverability of Microbial Colonies from Marine Sponge Samples
Olson, J. B., Lord, C. C., & McCarthy, P. J. (2000) · Microbial Ecology · doi:10.1007/s002480000058 · Cited by 71 · see citing works
From monsoons to microbes: understanding the ocean's role in human health
(2000) · Choice Reviews Online · doi:10.5860/choice.37-4535 · Cited by 69 · see citing works
New Cytotoxic Indolic Metabolites from a Marine Streptomyces
López, J. M. S., Insua, M. M., BAZ, J. P., PUENTES, J. L. F., & Cañedo, L. M. (2003) · Journal of Natural Products · doi:10.1021/np0204444 · Cited by 68 · see citing works
Remarkable Bacterial Diversity in the Tidal Flat Sediment as Revealed by 16S rDNA Analysis
Kim, B. S., Oh, H. M., Kang, H., et al. (2004) · Seoul National University Open Repository (Seoul National University) · Cited by 67 · see citing works
Madrid, V. M., Aller, J. Y., Aller, R. C., & CHISTOSERDOV, A. Y. (2001) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2001.tb00867.x · Cited by 67 · see citing works
Gutingimycin: A Highly Complex Metabolite from a Marine Streptomycete
Maskey, R. P., Sevvana, M., Usón, I., Helmke, E., & Laatsch, H. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200352312 · Cited by 63 · see citing works
Komodoquinone A, a Novel Neuritogenic Anthracycline, from Marine Streptomyces sp. KS3
Ito, T., Kinoshita, M., Aoki, S., & Kobayashi, M. (2003) · Journal of Natural Products · doi:10.1021/np030212k · Cited by 58 · see citing works
Williamsia maris sp. nov., a novel actinomycete isolated from the Sea of Japan
Stach, J. E. M., Maldonado, L. A., Ward, A. C., et al. (2004) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.02767-0 · Cited by 55 · see citing works
A New Cyclic Peptide from a Marine-Derived Bacterium of the GenusNocardiopsis
Shin, J., Seo, Y., Lee, H., Rho, J., & Mo, S. J. (2003) · Journal of Natural Products · doi:10.1021/np030075r · Cited by 47 · see citing works
Rodriguez, J. C., PUENTES, J. L. F., BAZ, J. P., & Cañedo, L. M. (2003) · The Journal of Antibiotics · doi:10.7164/antibiotics.56.318 · Cited by 46 · see citing works
Microbial symbionts of the Australian Great Barrier Reef sponge, Candidaspongia flabellata
Burja, A. M., & Hill, R. T. (2001) · Hydrobiologia · doi:10.1023/a:1012713130404 · Cited by 44 · see citing works
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Marine Natural Products: A Source of Novel Anticancer Drugs
Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., Moustafa, M. S., Abd El-Wahed, A., Al-Mousawi, S. M., Musharraf, S. G., et al. (2019) · Marine Drugs · doi:10.3390/md17090491 · Cited by 555 · see citing works
- Authors
- Lam, K. S.
- Corresponding author
- Lam, Kin S
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 9
- Issue
- 3
- Pages
- 245-251
- ISSN
- 1369-5274 (ISSN-L)
- OpenAlex
- W2091729115
- Cited by
- 539
- References
- 74
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 18 · 2023: 18 · 2022: 27 · 2021: 31 · 2020: 30 · 2019: 25 · 2018: 27 · 2017: 31 · 2016: 46 · 2015: 47 · 2014: 39 · 2013: 57 · 2012: 32
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
- Keywords
- marine actinomycetes, novel metabolites, secondary metabolites, marine natural products, actinomycete isolation, biological activity, therapeutic agents, marine microbial diversity
- MeSH terms
- Anti-Bacterial Agents, Antifungal Agents, Antineoplastic Agents, Seawater, Actinobacteria
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