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A One‐Pot Total Synthesis of Crambin
Abstract
Making up for lost time: The one-pot synthesis of crambin (see structure) with only a single final purification step gave the target protein of exceptional purity in only two days with an overall yield of ≈40 %. Three unprotected peptide segments were linked by native chemical ligation, and the polypeptide chain assumed its 3D structure without intermediate purification steps.
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Cited by
Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations
Agouridas, V., El Mahdi, O., Diemer, V., Cargoët, M., Monbaliu, J.-C. M., & Melnyk, O. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00712 · Cited by 650
Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins
Bondalapati, S., Jbara, M., & Brik, A. (2016) · Nature Chemistry · doi:10.1038/nchem.2476 · Cited by 359
Chemical Synthesis of Proteins
Nilsson, B. L., Soellner, M. B., & Raines, R. T. (2005) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.34.040204.144700 · Cited by 329
Rapid and efficient protein synthesis through expansion of the native chemical ligation concept
Kulkarni, S. S., Sayers, J., Premdjee, B., & Payne, R. J. (2018) · Nature Reviews Chemistry · doi:10.1038/s41570-018-0122 · Cited by 323
Kinetically Controlled Ligation for the Convergent Chemical Synthesis of Proteins
Bang, D., Pentelute, B. L., & Kent, S. B. H. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200600702 · Cited by 287
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Metadata
- Authors
- Bang, D., & Kent, S. B. H.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2004-04-28
- Volume
- 43
- Issue
- 19
- Pages
- 2534-2538
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2138995597
- Cited by
- 380
- References
- 0
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- closed
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