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Single‐Triggered Trimeric Prodrugs
Abstract
The knock-on effect of a single catalytic reaction by a specific enzyme on a prodrug platform initiates the sequential collapse of the whole array to release the active drug units (see scheme). Such a dendritic system may provide a means to improve selective chemotherapeutic approaches in cancer therapy.
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Citations
Cited by
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
van Dongen, S. F. M., de Hoog, H.-P. M., Peters, R. J. R. W., Nallani, M., Nolte, R. J. M., & van Hest, J. C. M. (2009) · Chemical Reviews · doi:10.1021/cr900072y · Cited by 386
Self‐Immolative Spacers: Kinetic Aspects, Structure–Property Relationships, and Applications
Alouane, A., Labruère, R., Le Saux, T., Schmidt, F., & Jullien, L. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201500088 · Cited by 379
Dendrimers Derived from 1 → 3 Branching Motifs
Newkome, G. R., & Shreiner, C. (2010) · Chemical Reviews · doi:10.1021/cr900341m · Cited by 347
Metadata
- Authors
- Haba, K., Popkov, M., Shamis, M., Lerner, R. A., Barbas, C. F., & Shabat, D.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2005-01-18
- Volume
- 44
- Issue
- 5
- Pages
- 716-720
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2144563093
- Cited by
- 161
- References
- 0
- FWCI
- 12.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Haba, K., Popkov, M., Shamis, M., Lerner, R. A., Barbas, C. F., & Shabat, D. (2005). Single‐Triggered Trimeric Prodrugs. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200461657
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
