The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Self‐Immolative Spacers: Kinetic Aspects, Structure–Property Relationships, and Applications
Abstract
Self‐immolative spacers are covalent assemblies tailored to correlate the cleavage of two chemical bonds after activation of a protective part in a precursor: Upon stimulation, the protective moiety is removed, which generates a cascade of disassembling reactions leading to the temporally sequential release of smaller molecules. Originally introduced to overcome limitations for drug delivery, self‐immolative spacers have gained wide interest in medicinal chemistry, analytical chemistry, and material science. For most applications, the kinetics of the disassembly of the activated self‐immolative spacer governs functional properties. This Review addresses kinetic aspects of self‐immolation. It provides information for selecting a particular self‐immolative motif for a specific demand. Moreover, it should help researchers design kinetic experiments and fully exploit the rich perspectives of self‐immolative spacers.
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Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and Efficacy
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UV and Near-IR Triggered Release from Polymeric Nanoparticles
Fomina, N., McFearin, C., Sermsakdi, M., Edigin, O., & Almutairi, A. (2010) · Journal of the American Chemical Society · doi:10.1021/ja102595j · Cited by 362
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A novel connector linkage applicable in prodrug design
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Cited by
Materials learning from life: concepts for active, adaptive and autonomous molecular systems
Merindol, R., & Walther, A. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00738d · Cited by 533
Zhang, X., Chen, Y., He, H., Wang, S., Lei, Z., & Zhang, F. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202109728 · Cited by 176
Self-immolative Linkers in Prodrugs and Antibody Drug Conjugates in Cancer Treatment
Edupuganti, V. V. S. R., Tyndall, J. D. A., & Gamble, A. B. (2021) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/1574892816666210509001139 · Cited by 36
Metadata
- Authors
- Alouane, A., Labruère, R., Le Saux, T., Schmidt, F., & Jullien, L.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2015-06-05
- Volume
- 54
- Issue
- 26
- Pages
- 7492-7509
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W1945627170
- Cited by
- 379
- References
- 82
- FWCI
- 10.94
- Type
- journal article
- Language
- en
- Open access
- closed
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