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Multistep Continuous‐Flow Microchemical Synthesis Involving Multiple Reactions and Separations
Abstract
All for one and one for all: A continuous-flow, multistep microchemical synthesis of carbamates starting from aqueous azide and organic azoyl chloride by using the Curtius rearrangement reaction is described. The procedure involves three reaction steps and two separation steps (one gas–liquid and one liquid–liquid). Formation of a microreactor network for parallel synthesis of analogous compounds is also demonstrated.
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Cited by
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Plutschack, M. B., Pieber, B., Gilmore, K., & Seeberger, P. H. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00183 · Cited by 1,995
Seemann, R., Brinkmann, M., Pfohl, T., & Herminghaus, S. (2012) · Reports on Progress in Physics · doi:10.1088/0034-4885/75/1/016601 · Cited by 1,049
Synthesis of micro and nanostructures in microfluidic systems
Marre, S., & Jensen, K. F. (2010) · Chemical Society Reviews · doi:10.1039/b821324k · Cited by 734
Self-citationTaming hazardous chemistry by continuous flow technology
Movsisyan, M., Delbeke, E. I. P., Berton, J. K. E. T., Battilocchio, C., Ley, S. V., & Stevens, C. V. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00902b · Cited by 692
Microchemical systems for continuous-flow synthesis
Hartman, R. L., & Jensen, K. F. (2009) · Lab on a Chip · doi:10.1039/b906343a · Cited by 508
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Metadata
- Authors
- Sahoo, H. R., Kralj, J. G., & Jensen, K. F.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2007-07-13
- Volume
- 46
- Issue
- 30
- Pages
- 5704-5708
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2111820881
- Cited by
- 397
- References
- 0
- FWCI
- 26.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sahoo, H. R., Kralj, J. G., & Jensen, K. F. (2007). Multistep Continuous‐Flow Microchemical Synthesis Involving Multiple Reactions and Separations. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200701434
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