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Ion Mobility–Mass Spectrometry Reveals Long‐Lived, Unfolded Intermediates in the Dissociation of Protein Complexes
Abstract
Folded or not? Ion mobility–mass spectrometry investigation of an activated macromolecular protein complex lends insight into the structures of intermediates formed in the dissociation process. The activated ions of human tetrameric transthyretin populate partially folded intermediate states (see picture; folded subunits in blue, partially unfolded subunits in red) prior to dissociation.
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Citations
Cited by
Native mass spectrometry: a bridge between interactomics and structural biology
Heck, A. J. R. (2008) · Nature Methods · doi:10.1038/nmeth.1265 · Cited by 766
Ion mobility mass spectrometry of proteins and proteinassemblies
Uetrecht, C., Rose, R. J., van Duijn, E., Lorenzen, K., & Heck, A. J. R. (2010) · Chem. Soc. Rev. · doi:10.1039/b914002f · Cited by 462
Collision Cross Sections for Structural Proteomics
Marklund, E. G., Degiacomi, M. T., Robinson, C. V., Baldwin, A. J., & Benesch, J. L. P. (2015) · Structure · doi:10.1016/j.str.2015.02.010 · Cited by 270
Self-citationHall, Z., Politis, A., Bush, M. F., Smith, L. J., & Robinson, C. V. (2012) · Journal of the American Chemical Society · doi:10.1021/ja2096859 · Cited by 267
Self-citationCollision induced unfolding of isolated proteins in the gas phase: past, present, and future
Dixit, S. M., Polasky, D. A., & Ruotolo, B. T. (2018) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2017.11.010 · Cited by 235
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Metadata
- Authors
- Ruotolo, B. T., Hyung, S., Robinson, P. M., Giles, K., Bateman, R. H., & Robinson, C. V.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2007-10-12
- Volume
- 46
- Issue
- 42
- Pages
- 8001-8004
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2115569106
- Cited by
- 229
- References
- 0
- FWCI
- 7.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Ion Mobility–Mass Spectrometry Reveals Long‐Lived, Unfolded Intermediates in the Dissociation of Protein Complexes. https://app.cochat.ai/papers/10.1002/anie.200702161
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- Ruotolo, B. T., Hyung, S., Robinson, P. M., Giles, K., Bateman, R. H., & Robinson, C. V. (2007). Ion Mobility–Mass Spectrometry Reveals Long‐Lived, Unfolded Intermediates in the Dissociation of Protein Complexes. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200702161
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