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Synthesis of Natural‐Product‐Like Molecules with Over Eighty Distinct Scaffolds
Open accessAbstract
Seeking scaffold diversity: A synthetic approach for the combinatorial variation of the scaffolds of small molecules is described. Using just six basic reaction types, compounds with 84 distinct scaffolds were prepared. The compounds had many natural-product-like structural features including rich stereochemistry, heterocyclic and unsaturated ring systems, and dense functionalization.
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Diversity-oriented synthesis: Exploring the intersections between chemistry and biology
Tan, D. S. (2005) · Nature Chemical Biology · doi:10.1038/nchembio0705-74 · Cited by 605
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Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis
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Metadata
- Authors
- Morton, D., Leach, S., Cordier, C., Warriner, S., & Nelson, A.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2008-12-18
- Volume
- 48
- Issue
- 1
- Pages
- 104-109
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2067166068
- Cited by
- 224
- References
- 1
- FWCI
- 8.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Morton, D., Leach, S., Cordier, C., Warriner, S., & Nelson, A. (2009). Synthesis of Natural‐Product‐Like Molecules with Over Eighty Distinct Scaffolds. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200804486
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
