The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Interaction of Metal Complexes with G‐Quadruplex DNA
Abstract
Guanine‐rich sequences of DNA can assemble into tetrastranded structures known as G‐quadruplexes. It has been suggested that these secondary DNA structures could be involved in the regulation of several key biological processes. In the human genome, guanine‐rich sequences with the potential to form G‐quadruplexes exist in the telomere as well as in promoter regions of certain oncogenes. The identification of these sequences as novel targets for the development of anticancer drugs has sparked great interest in the design of molecules that can interact with quadruplex DNA. While most reported quadruplex DNA binders are based on purely organic templates, numerous metal complexes have more recently been shown to interact effectively with this DNA secondary structure. This Review provides an overview of the important roles that metal complexes can play as quadruplex DNA binding molecules, highlighting the unique properties metals can confer to these molecules.
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Cites
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Cited by
Zhou, W., Saran, R., & Liu, J. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00063 · Cited by 931
Gill, M. R., & Thomas, J. A. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15299a · Cited by 747
Bioactive Luminescent Transition‐Metal Complexes for Biomedical Applications
Ma, D., He, H., Leung, K., Chan, D. S., & Leung, C. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201208414 · Cited by 388
Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA
Xu, Y. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00134a · Cited by 323
Recent advances in luminescent heavy metal complexes for sensing
Ma, D.-L., Ma, V. P.-Y., Chan, D. S.-H., Leung, K.-H., He, H.-Z., & Leung, C.-H. (2012) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2012.07.005 · Cited by 296
Metadata
- Authors
- Georgiades, S. N., Abd Karim, N. H., Suntharalingam, K., & Vilar, R.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2010-05-26
- Volume
- 49
- Issue
- 24
- Pages
- 4020-4034
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W1989226481
- Cited by
- 486
- References
- 5
- FWCI
- 13.23
- Type
- journal article
- Language
- en
- Open access
- closed
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