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Iridium Complex with Antiangiogenic Properties
Open accessAbstract
Identified as nanomolar and selective inhibitor of receptor protein kinase VEGFR3 (Flt4), the nontoxic and octahedrally coordinated IrIII complex 1 was synthesized by a stereoselective oxidative addition to a square-planar coordinated IrI precursor. The arrows in the image indicate positions at which the blood vessel formation in a zebrafish model of angiogenesis has been hampered by 1.
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Citations
Cited by
You, Y., & Nam, W. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35171d · Cited by 668
Organometallic Half-Sandwich Iridium Anticancer Complexes
Liu, Z., Habtemariam, A., Pizarro, A. M., Fletcher, S. A., Kisova, A., Vrana, O., Salassa, L., Bruijnincx, P. C. A., Clarkson, G. J., Brabec, V., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm2000932 · Cited by 357
Hybrid Organic–Inorganic Inhibitors of a PDZ Interaction that Regulates the Endocytic Fate of CFTR
Kundu, R., Cushing, P. R., Popp, B. V., Zhao, Y., Madden, D. R., & Ball, Z. T. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201202291 · Cited by 33
Metadata
- Authors
- Wilbuer, A., Vlecken, D. H., Schmitz, D. J., Kräling, K., Harms, K., Bagowski, C. P., & Meggers, E.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2010-05-10
- Volume
- 49
- Issue
- 22
- Pages
- 3839-3842
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2113414630
- Cited by
- 168
- References
- 0
- FWCI
- 7.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wilbuer, A., Vlecken, D. H., Schmitz, D. J., Kräling, K., Harms, K., Bagowski, C. P., & Meggers, E. (2010). Iridium Complex with Antiangiogenic Properties. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201000682
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
