Hybrid Organic–Inorganic Inhibitors of a PDZ Interaction that Regulates the Endocytic Fate of CFTR
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Together strong: Cooperative binding of organic (see picture, red) and inorganic fragments provides a strategy for the potent inhibition of protein-protein interactions. By targeting specific Lewis basic side chains in peripheral regions of the binding site for coordination to a rhodium(II) center, the affinity of otherwise weak ligands is improved.
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- Authors
- Kundu, R., Cushing, P. R., Popp, B. V., Zhao, Y., Madden, D. R., & Ball, Z. T.
- Affiliations
- Rice University (US)
- Dartmouth College (US)
- West Virginia University (US)
- Corresponding author
- Madden, Dean R.
- Ball, Zachary T.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2012-06-14
- Volume
- 51
- Issue
- 29
- Pages
- 7217-7220
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- PMC
- PMC3677582
- OpenAlex
- W2124643439
- Cited by
- 33
- References
- 56
- Citations by year
- 2026: 1 · 2025: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2016: 2 · 2015: 9 · 2014: 7 · 2013: 1 · 2012: 4
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Rice Research Repository (Rice University) (acceptedVersion)
- Rice Research Repository (Rice University) (submittedVersion)
- Funders
- National Institutes of Health (5p20rr018787-07)
- National Institute of General Medical Sciences (P20GM103413, T32GM008704)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK075309)
- National Center for Research Resources (P20-RR018787)
- Topics
- Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
- Physical Sciences › Chemistry › Organic Chemistry › Supramolecular Chemistry and Complexes
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Keywords
- CFTR, protein-protein interaction inhibitors, rhodium(II) complexes, endocytosis, cooperative binding, binding affinity enhancement
- MeSH terms
- Golgi Matrix Proteins, Amino Acid Sequence, Carrier Proteins, Humans, Membrane Proteins, Models, Molecular, Molecular Sequence Data, Organometallic Compounds, Peptides, Rhodium, Cystic Fibrosis Transmembrane Conductance Regulator, Membrane Transport Proteins, Adaptor Proteins, Signal Transducing, PDZ Domains
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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