Cited by 33Metal complexes synthesis and propertiesSupramolecular Chemistry and ComplexesMolecular Sensors and Ion Detection

Hybrid Organic–Inorganic Inhibitors of a PDZ Interaction that Regulates the Endocytic Fate of CFTR

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Kundu, Rituparna, Cushing, Patrick R., Popp, Brian V., Zhao, Yu, Madden, Dean R., Ball, Zachary T.·2012·Angewandte Chemie International Edition

Abstract

Together strong: Cooperative binding of organic (see picture, red) and inorganic fragments provides a strategy for the potent inhibition of protein-protein interactions. By targeting specific Lewis basic side chains in peripheral regions of the binding site for coordination to a rhodium(II) center, the affinity of otherwise weak ligands is improved.

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Crossref · 10.1002/anie.201202291

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  1. Verdine GL Mol. Cancer Ther 2007 6 3623S 3623S b) Hu X Sun J Wang H-G Manetsch R J. Am. Chem. Soc 2008 130 13820 13821 18811158 PMC2574679 c) Kulkarni SS Hu X Doi K Wang H-G Manetsch R ACS Chem. Biol 2011 6 724 732 21506574 PMC3151735
  2. [9]Chifotides HT Dunbar KR Cotton FA Murillo C Walton RA Multiple Bonds Between Metal Atoms 2005 465 589 Springer New York 3rd ed
  3. Lee SH Chao DL Bear JL Kimball AP Cancer Chemother. Rep. 1 1975 59 661 663 1203890 b) Howard RA Spring TG Bear JL Cancer Res 1976 36 4402 4405 1000490

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Authors
Kundu, R., Cushing, P. R., Popp, B. V., Zhao, Y., Madden, D. R., & Ball, Z. T.
Affiliations
  • Rice University (US)
  • Dartmouth College (US)
  • West Virginia University (US)
Corresponding author
  • Madden, Dean R.
  • Ball, Zachary T.
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2012-06-14
Volume
51
Issue
29
Pages
7217-7220
ISSN
  • 1433-7851 (ISSN-L)
  • 1521-3773
OpenAlex
W2124643439
Cited by
33
References
56
Citations by year
2026: 1 · 2025: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2016: 2 · 2015: 9 · 2014: 7 · 2013: 1 · 2012: 4
FWCI
3.32
Type
journal article
Language
en
Open access
Locations
  • Angewandte Chemie International Edition (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Rice Research Repository (Rice University) (acceptedVersion)
  • Rice Research Repository (Rice University) (submittedVersion)
Funders
  • National Institutes of Health (5p20rr018787-07)
  • National Institute of General Medical Sciences (P20GM103413, T32GM008704)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK075309)
  • National Center for Research Resources (P20-RR018787)
Topics
  • Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
  • Physical Sciences › Chemistry › Organic Chemistry › Supramolecular Chemistry and Complexes
  • Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
Keywords
CFTR, protein-protein interaction inhibitors, rhodium(II) complexes, endocytosis, cooperative binding, binding affinity enhancement
MeSH terms
Golgi Matrix Proteins, Amino Acid Sequence, Carrier Proteins, Humans, Membrane Proteins, Models, Molecular, Molecular Sequence Data, Organometallic Compounds, Peptides, Rhodium, Cystic Fibrosis Transmembrane Conductance Regulator, Membrane Transport Proteins, Adaptor Proteins, Signal Transducing, PDZ Domains

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