The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Factors Determining the Selection of Organic Reactions by Medicinal Chemists and the Use of These Reactions in Arrays (Small Focused Libraries)
Abstract
Synthetic organic reactions are a fundamental enabler of small‐molecule drug discovery, and the vast majority of medicinal chemists are initially trained—either at universities or within industry—as synthetic organic chemists. The sheer breadth of synthetic methodology available to the medicinal chemist represents an almost endless source of innovation. But what reactions do medicinal chemists use in drug discovery? And what criteria do they use in selecting synthetic methodology? Why are arrays (small focused libraries) so powerful in the lead‐optimization process? In this Minireview, we suggest some answers to these questions and also describe how we have tried to expand the number of robust reactions available to the medicinal chemist.
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Cites
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Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
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Can the pharmaceutical industry reduce attrition rates?
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How to improve R&D productivity: the pharmaceutical industry's grand challenge
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Generation of a Set of Simple, Interpretable ADMET Rules of Thumb
Gleeson, M. P. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm701122q · Cited by 969
A Mathematical Contribution to Structure-Activity Studies
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Physiochemical drug properties associated with in vivo toxicological outcomes
Hughes, J. D., Blagg, J., Price, D. A., Bailey, S., DeCrescenzo, G. A., Devraj, R. V., Ellsworth, E., Fobian, Y. M., Gibbs, M. E., Gilles, R. W., et al. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.07.071 · Cited by 946
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Self-citation
Cited by
Focused Libraries for Epigenetic Drug Discovery: The Importance of Isosteres: Miniperspective
Green, A. I., & Burslem, G. M. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00592 · Cited by 21
Metadata
- Authors
- Cooper, T. W. J., Campbell, I. B., & Macdonald, S. J. F.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2010-09-21
- Volume
- 49
- Issue
- 44
- Pages
- 8082-8091
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2143831413
- Cited by
- 299
- References
- 19
- FWCI
- 7.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cooper, T. W. J., Campbell, I. B., & Macdonald, S. J. F. (2010). Factors Determining the Selection of Organic Reactions by Medicinal Chemists and the Use of These Reactions in Arrays (Small Focused Libraries). Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201002238
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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