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Cited by 946

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Physiochemical drug properties associated with in vivo toxicological outcomes

Hughes, Jason D., Blagg, Julian, Price, David A., Bailey, Simon, DeCrescenzo, Gary A., Devraj, Rajesh V., Ellsworth, Edmund, Fobian, Yvette M., Gibbs, Michael E., Gilles, Richard W., Greene, Nigel, Huang, Enoch, Krieger-Burke, Teresa, Loesel, Jens, Wager, Travis, Whiteley, Larry, Zhang, Yao·2008·Bioorganic & Medicinal Chemistry Letters
DOI 10.1016/j.bmcl.2008.07.071
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Abstract

Relationships between physicochemical drug properties and toxicity were inferred from a data set consisting of animal in vivo toleration (IVT) studies on 245 preclinical Pfizer compounds; an increased likelihood of toxic events was found for less polar, more lipophilic compounds. This trend held across a wide range of types of toxicity and across a broad swath of chemical space.

Overview

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Crossref · 10.1016/j.bmcl.2008.07.071

Cites

2 of 2 references verified0 citation errors · 0 not checkable

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Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 13

  1. Kramer, 2007, Nat. Rev. Drug Disc., 6, 636, 10.1038/nrd2378 · DOI
  2. Stevens, 2006, Chem. Res. Toxicol., 19, 1393, 10.1021/tx060213n · DOI
  3. Song, 2006, J. Chem. Inf. Model., 46, 392, 10.1021/ci050308f · DOI
  4. Villar, 2007, Curr. Top. Med. Chem., 7, 1509, 10.2174/156802607782194725 · DOI
  5. Blagg, 2006, Ann. Rep. Med. Chem., 41, 353
  6. Robichaud, 2001, Neuropharmacology, 40, 262, 10.1016/S0028-3908(00)00142-8 · DOI
  7. Smith, 2005, Curr. Opin. Investig. Drugs, 6, 1136
  8. Krejsa, 2003, Curr. Opin. Drug Discov. Dev., 6, 470
  9. Kalgutkar, 2005, Expert Opin. Drug Metab. Toxicol., 1, 91, 10.1517/17425255.1.1.91 · DOI
  10. Kalgutkar, 2005, Curr. Drug Metab., 6, 161, 10.2174/1389200054021799 · DOI
  11. Ertl, 2000, J. Med. Chem., 43, 371, 10.1021/jm000942e · DOI
  12. Gleeson, 2007, J. Med. Chem., 50, 101, 10.1021/jm060981b · DOI
  13. Azzaoui, 2007, ChemMedChem, 2, 874, 10.1002/cmdc.200700036 · DOI

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Metadata

Authors
Hughes, J. D., Blagg, J., Price, D. A., Bailey, S., DeCrescenzo, G. A., Devraj, R. V., Ellsworth, E., Fobian, Y. M., Gibbs, M. E., Gilles, R. W., Greene, N., Huang, E., Krieger-Burke, T., Loesel, J., Wager, T., Whiteley, L., & Zhang, Y.
Venue
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier BV
Published
2008-09
Volume
18
Issue
17
Pages
4872-4875
ISSN
0960-894X
DOI
10.1016/j.bmcl.2008.07.071
Cited by
946
References
2
Language
en
Licence

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