The DOI matches its Crossref record.
Intracellular pH‐Responsive Mesoporous Silica Nanoparticles for the Controlled Release of Anticancer Chemotherapeutics
Abstract
Cut here to cure: Doxorubicin attached to pH-sensitive mesoporous silica nanoparticles (MSN-hydrazone-Dox) shows potential in the chemotherapeutic treatment of liver cancer. Hydrolysis of the pH-sensitive hydrazone bond in the acidic environment of endosomes/lysosomes (see picture) releases Dox intracellularly from the MSN nanochannels, resulting in highly efficient apoptotic cell death.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Stimuli-responsive nanocarriers for drug delivery
Mura, S., Nicolas, J., & Couvreur, P. (2013) · Nature Materials · doi:10.1038/nmat3776 · Cited by 6,289
Nanomaterials: Applications in Cancer Imaging and Therapy
Barreto, J. A., O’Malley, W., Kubeil, M., Graham, B., Stephan, H., & Spiccia, L. (2011) · Advanced Materials · doi:10.1002/adma.201100140 · Cited by 907
Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals
Homayun, B., Lin, X., & Choi, H.-J. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11030129 · Cited by 837
Croissant, J. G., Fatieiev, Y., Almalik, A., & Khashab, N. M. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201700831 · Cited by 594
Mesoporous silica nanoparticles for therapeutic/diagnostic applications
Jafari, S., Derakhshankhah, H., Alaei, L., Fattahi, A., Varnamkhasti, B. S., & Saboury, A. A. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.10.167 · Cited by 566
Metadata
- Authors
- Lee, C., Cheng, S., Huang, I., Souris, J. S., Yang, C., Mou, C., & Lo, L.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2010-09-23
- Volume
- 49
- Issue
- 44
- Pages
- 8214-8219
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2164060969
- Cited by
- 352
- References
- 0
- FWCI
- 12.33
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Intracellular pH‐Responsive Mesoporous Silica Nanoparticles for the Controlled Release of Anticancer Chemotherapeutics. https://app.cochat.ai/papers/10.1002/anie.201002639
- The paper
- Lee, C., Cheng, S., Huang, I., Souris, J. S., Yang, C., Mou, C., & Lo, L. (2010). Intracellular pH‐Responsive Mesoporous Silica Nanoparticles for the Controlled Release of Anticancer Chemotherapeutics. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201002639
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
