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Genetically Encoded Copper‐Free Click Chemistry
Open accessAbstract
A bright click of life: Strained alkynes are genetically encoded into E. coli by use of an engineered pyrrolysine amber suppressor tRNA/synthetase pair from Methanosarcina mazei. As a result cyclooctynyl lysine derivatives were incorporated site-specifically in proteins allowing efficient labeling with fluorogenic azide-bearing dyes by means of a click reaction under physiological conditions in vitro and in vivo (see scheme).
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Citations
Cited by
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
Thirumurugan, P., Matosiuk, D., & Jozwiak, K. (2013) · Chemical Reviews · doi:10.1021/cr200409f · Cited by 1,896
Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins
Lang, K., & Chin, J. W. (2014) · Chemical Reviews · doi:10.1021/cr400355w · Cited by 1,035
A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins
Lukinavičius, G., Umezawa, K., Olivier, N., Honigmann, A., Yang, G., Plass, T., Mueller, V., Reymond, L., Corrêa Jr, I. R., Luo, Z.-G., et al. (2013) · Nature Chemistry · doi:10.1038/nchem.1546 · Cited by 893
Self-citationClick Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation
McKay, C. S., & Finn, M. G. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2014.09.002 · Cited by 768
Expanding and Reprogramming the Genetic Code of Cells and Animals
Chin, J. W. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035737 · Cited by 476
Metadata
- Authors
- Plass, T., Milles, S., Koehler, C., Schultz, C., & Lemke, E. A.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2011-03-23
- Volume
- 50
- Issue
- 17
- Pages
- 3878-3881
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2134796998
- Cited by
- 322
- References
- 0
- FWCI
- 14.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Plass, T., Milles, S., Koehler, C., Schultz, C., & Lemke, E. A. (2011). Genetically Encoded Copper‐Free Click Chemistry. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201008178
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
