The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation
Open accessAbstract
The selective chemical modification of biological molecules drives a good portion of modern drug development and fundamental biological research. While a few early examples of reactions that engage amine and thiol groups on proteins helped establish the value of such processes, the development of reactions that avoid most biological molecules so as to achieve selectivity in desired bond-forming events has revolutionized the field. We provide an update on recent developments in bioorthogonal chemistry that highlights key advances in reaction rates, biocompatibility, and applications. While not exhaustive, we hope this summary allows the reader to appreciate the rich continuing development of good chemistry that operates in the biological setting.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Tornøe, C. W., Christensen, C., & Meldal, M. (2002) · The Journal of Organic Chemistry · doi:10.1021/jo011148j · Cited by 8,696
Adding New Chemistries to the Genetic Code
Liu, C. C., & Schultz, P. G. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.105824 · Cited by 1,725 · cited 2×
“…Ngo and Tirrell, 2011; Tang et al., 2009) or site-specific manner (Carrico et al., 2007; Chin et al., 2003; Hudak et al., 2012; Hudak et al., 2011; Liu and Schultz, 2010; Wang et al., 2003a; Wu et al., 2009), and use in peptide tags that direct enzymatic ligation of aldehyde or ketone bearing…”
BackgroundThe convergence of synthetic organic and polymer chemistries
Hawker, C. J., & Wooley, K. L. (2005) · Science · doi:10.1126/science.1109778 · Cited by 1,298
Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones
Jewett, J. C., Sletten, E. M., & Bertozzi, C. R. (2010) · Journal of the American Chemical Society · doi:10.1021/ja100014q · Cited by 697
Cellular pathways for transport and efflux of ascorbate and dehydroascorbate
Corti, A., Casini, A. F., & Pompella, A. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.05.014 · Cited by 193 · cited 2×
“, 2013) side chains leading to protein crosslinking (Figure 4F) (Corti et al., 2010).”
BackgroundAllenamides as Orthogonal Handles for Selective Modification of Cysteine in Peptides and Proteins
Abbas, A., Xing, B., & Loh, T. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403121 · Cited by 117
Cited by
Residue-Specific Peptide Modification: A Chemist’s Guide
deGruyter, J. N., Malins, L. R., & Baran, P. S. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00536 · Cited by 573
Redox-Active Polymers for Energy Storage Nanoarchitectonics
Kim, J., Kim, J. H., & Ariga, K. (2017) · Joule · doi:10.1016/j.joule.2017.08.018 · Cited by 549
Redox-based reagents for chemoselective methionine bioconjugation
Lin, S., Yang, X., Jia, S., Weeks, A. M., Hornsby, M., Lee, P. S., Nichiporuk, R. V., Iavarone, A. T., Wells, J. A., Toste, F. D., et al. (2017) · Science · doi:10.1126/science.aal3316 · Cited by 513
Click Chemistry in Proteomic Investigations
Parker, C. G., & Pratt, M. R. (2020) · Cell · doi:10.1016/j.cell.2020.01.025 · Cited by 380
Cell-type-specific metabolic labeling, detection and identification of nascent proteomes in vivo
Alvarez-Castelao, B., Schanzenbächer, C. T., Langer, J. D., & Schuman, E. M. (2019) · Nature Protocols · doi:10.1038/s41596-018-0106-6 · Cited by 84
Metadata
- Authors
- McKay, C. S., & Finn, M. G.
- Venue
- Chemistry & Biology
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 21
- Issue
- 9
- Pages
- 1075-1101
- ISSN
- 1074-5521 (ISSN-L)
- OpenAlex
- W2046236732
- Cited by
- 768
- References
- 6
- FWCI
- 29.05
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation. https://app.cochat.ai/papers/10.1016/j.chembiol.2014.09.002
- The paper
- McKay, C. S., & Finn, M. G. (2014). Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation. Chemistry & Biology. https://doi.org/10.1016/j.chembiol.2014.09.002
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
