The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Reliable and Efficient Procedures for the Conjugation of Biomolecules through Huisgen Azide–Alkyne Cycloadditions
Abstract
The Cu I‐catalyzed azide–alkyne cycloaddition (CuAAC) has been established as a powerful coupling technology for the conjugation of proteins, nucleic acids, and polysaccharides. Nevertheless, several shortcomings related to the presence of Cu, mainly oxidative degradation by reactive oxygen species and sample contamination by Cu, have been pointed out. This Minireview discusses key aspects found in the development of the efficient and benign functionalization of biomacromolecules through CuAAC, as well as the Cu‐free strain‐promoted azide–alkyne cycloaddition (SPAAC).
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Cites
Tornøe, C. W., Christensen, C., & Meldal, M. (2002) · The Journal of Organic Chemistry · doi:10.1021/jo011148j · Cited by 8,696
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
Oxidative Nucleobase Modifications Leading to Strand Scission
Burrows, C. J., & Muller, J. G. (1998) · Chemical Reviews · doi:10.1021/cr960421s · Cited by 1,736
CuI‐Catalyzed Alkyne–Azide “Click” Cycloadditions from a Mechanistic and Synthetic Perspective
Bock, V. D., Hiemstra, H., & van Maarseveen, J. H. (2006) · European Journal of Organic Chemistry · doi:10.1002/ejoc.200500483 · Cited by 1,452
Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones
Jewett, J. C., Sletten, E. M., & Bertozzi, C. R. (2010) · Journal of the American Chemical Society · doi:10.1021/ja100014q · Cited by 697
Cited by
BODIPY-based probes for the fluorescence imaging of biomolecules in living cells
Kowada, T., Maeda, H., & Kikuchi, K. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00030k · Cited by 1,381
Xuan, J., & Studer, A. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00912c · Cited by 482
50th Anniversary Perspective: Polymer Functionalization
Blasco, E., Sims, M. B., Goldmann, A. S., Sumerlin, B. S., & Barner-Kowollik, C. (2017) · Macromolecules · doi:10.1021/acs.macromol.7b00465 · Cited by 437
Metadata
- Authors
- Lallana, E., Riguera, R., & Fernandez‐Megia, E.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2011-08-17
- Volume
- 50
- Issue
- 38
- Pages
- 8794-8804
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2157271026
- Cited by
- 328
- References
- 5
- FWCI
- 15.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lallana, E., Riguera, R., & Fernandez‐Megia, E. (2011). Reliable and Efficient Procedures for the Conjugation of Biomolecules through Huisgen Azide–Alkyne Cycloadditions. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201101019
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