[1] Role of free radicals and catalytic metal ions in human disease: An overview

Halliwell, Barry; Gutteridge, John M.C.

doi:10.1016/0076-6879(90)86093-b

Cited by 4,994Antioxidant Activity and Oxidative StressRedox biology and oxidative stressTrace Elements in Health

[1] Role of free radicals and catalytic metal ions in human disease: An overview

Halliwell, Barry, Gutteridge, John M.C.·1990·Methods in Enzymology

DOI 10.1016/0076-6879(90)86093-b

Open this paper in CoChat — free account

Integrity signals

Registry

Crossref · 10.1016/0076-6879(90)86093-b

Cites

562 of 562 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Reactions of peroxide and superoxide with poorly liganded iron species can lead to catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging and a major cause of chronic inflammation.
“Possibly the commonest means by which such much more damaging species, in particular the hydroxyl radical, are created is by reaction with unliganded or incompletely liganded iron ions [61-63].”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [62]
The commonest means by which hydroxyl radical is created is reaction with unliganded or incompletely liganded iron ions.
“Possibly the commonest means by which such much more damaging species, in particular the hydroxyl radical, are created is by reaction with unliganded or incompletely liganded iron ions [61-63].”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [62]
Iron ions may catalyze free radical generation in biological systems, playing a key role in the toxicity of several mineral dusts.
“iron ions may catalyze free radical generation in biological systems 3-5 thus playing a key role in the toxicity of several mineral dusts 6-8 .”
From Hematite Nanoparticles Larger than 90 nm Show No Sign of Toxicity in Terms of Lactate Dehydrogenase Release, Nitric Oxide Generation, Apoptosis, and Comet Assay in Murine Alveolar Macrophages and Human Lung Epithelial Cells (2012) · cites this paper as [3]
Superoxide radical is necessary to achieve redox cycling of metal ions.
“This can be explained by the fact, that superoxide radical is necessary to achieve redox cycling of metal ions (Halliwell and Gutteridge 1990).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Halliwell and Gutteridge 1990

Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178 · see citing works
Self-citation
Beyond Cholesterol
Epstein, F. H., Steinberg, D. I., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904063201407 · Cited by 6,425 · see citing works
Oxygen-Derived Free Radicals in Postischemic Tissue Injury
Epstein, F. H., & McCord, J. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120305 · Cited by 5,399 · see citing works
Oxygen toxicity, oxygen radicals, transition metals and disease
Halliwell, B., & Gutteridge, J. M. C. (1984) · Biochemical Journal · doi:10.1042/bj2190001 · Cited by 5,330 · see citing works
Self-citation
The Pathogenesis of Atherosclerosis — An Update
Ross, R. (1986) · New England Journal of Medicine · doi:10.1056/nejm198602203140806 · Cited by 4,885 · see citing works
Free Radicals in Biology and Medicine
Land, E. T. (1990) · International Journal of Radiation Biology · doi:10.1080/09553009014552071 · Cited by 4,868 · see citing works
Untitled work
Fridovich (1978) · doi:10.1126/science.210504 · Cited by 3,329 · see citing works
Fenton's reagent revisited
Walling, C. T. (1975) · Accounts of Chemical Research · doi:10.1021/ar50088a003 · Cited by 2,853 · see citing works
Prooxidant States and Tumor Promotion
Cerutti, P. (1985) · Science · doi:10.1126/science.2981433 · Cited by 2,513 · see citing works
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448 · see citing works
The deoxyribose method: A simple “test-tube” assay for determination of rate constants for reactions of hydroxyl radicals
Halliwell, B. B., Gutteridge, J. M. C., & Aruoma, O. I. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90222-3 · Cited by 2,362 · see citing works
Self-citation
Book ReviewAmbulatory Pediatric Care
Steinberg, J. B. (1989) · New England Journal of Medicine · doi:10.1056/nejm198901053200122 · Cited by 2,121 · see citing works
Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts
Halliwell, B., & Gutteridge, J. M. C. (1986) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(86)90305-x · Cited by 2,038 · see citing works
Self-citation
DNA damage and oxygen radical toxicity
Imlay, J. A., & Linn, S. (1988) · Science · doi:10.1126/science.3287616 · Cited by 1,974 · see citing works
Superoxide Dismutases
Fridovich, I. (1975) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.44.070175.001051 · Cited by 1,735 · see citing works
The Liver: Biology and Pathobiology
Carey, W., & Fleshler, B. (1983) · JAMA · doi:10.1001/jama.1983.03330310070041 · Cited by 1,479 · see citing works
Free-Radical Chemistry of Cigarette Smoke and Its Toxicological Implications
CHURCH, D. F., & PRYOR, W. A. (1985) · Environmental Health Perspectives · doi:10.1289/ehp.8564111 · Cited by 1,442 · see citing works
Myocardial reperfusion: a double-edged sword?
D, E. B. M., & Kloner, R. A. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112160 · Cited by 1,368 · see citing works
Lipid peroxides and human diseases
Yagi, K. (1987) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(87)90071-5 · Cited by 1,325 · see citing works
Oxidants and human disease: some new concepts 1
Halliwell, B. B. (1987) · The FASEB Journal · doi:10.1096/fasebj.1.5.2824268 · Cited by 1,206 · see citing works
Self-citation
Superoxide Radical: An Endogenous Toxicant
Fridovich, I. (1983) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.23.040183.001323 · Cited by 1,168 · see citing works
Role of metals in oxygen radical reactions
Aust, S. D., Morehouse, L. A., & Thomas, C. E. (1985) · Journal of Free Radicals in Biology & Medicine · doi:10.1016/0748-5514(85)90025-x · Cited by 1,150 · see citing works
Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.
Carew, T. E., Schwenke, D. C., & Steinberg, D. H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7725 · Cited by 1,040 · see citing works
A compilation of specific bimolecular rate constants for the reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals with inorganic and organic compounds in aqueous solution
Anbar, M., & Neta, P. (1967) · The International Journal of Applied Radiation and Isotopes · doi:10.1016/0020-708x(67)90115-9 · Cited by 982 · see citing works
IRON AND THE SEX DIFFERENCE IN HEART DISEASE RISK
Sullivan, J. (1981) · The Lancet · doi:10.1016/s0140-6736(81)92463-6 · Cited by 969 · see citing works
The importance of free radicals and catalytic metal ions in human diseases.
Halliwell, B., & Gutteridge, J. M. C. (1985) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(85)90001-9 · Cited by 941 · see citing works
Self-citation
How to Characterize a Biological Antioxidant
Halliwell, B. B. (1990) · Free Radical Research Communications · doi:10.3109/10715769009148569 · Cited by 931 · see citing works
Self-citation
Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism
Wong, G. H. W., & Goeddel, D. V. (1988) · Science · doi:10.1126/science.3263703 · Cited by 914 · see citing works
The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma
Wayner, D. D. M., Burton, G. W., Ingold, K. U., Barclay, L. R. C., & Locke, S. J. (1987) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(87)90155-3 · Cited by 871 · see citing works
Superoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complex
McCord, J. M., & Day, E. D. (1978) · FEBS Letters · doi:10.1016/0014-5793(78)80116-1 · Cited by 870 · see citing works
Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site.
Graf, E., Mahoney, J. R., Bryant, R. G., & Eaton, J. W. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43139-5 · Cited by 855 · see citing works
Formation of a thiobarbituric‐acid‐reactive substance from deoxyribose in the presence of iron salts
Halliwell, B. B., & Gutteridge, J. M. C. (1981) · FEBS Letters · doi:10.1016/0014-5793(81)80114-7 · Cited by 832 · see citing works
Self-citation
Oxygen radicals and the nervous system
Halliwell, B. B., & Gutteridge, J. M. C. (1985) · Trends in Neurosciences · doi:10.1016/0166-2236(85)90010-4 · Cited by 822 · see citing works
Self-citation
Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes?
Burton, G. W., Joyce, A., & Ingold, K. U. (1983) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(83)90145-5 · Cited by 808 · see citing works
Separation and characterization of two extracelluar H2O2‐dependent oxidases from ligninolytic cultures of Phanerochaete chrysosporium
Kuwahara, M., Glenn, J. K., Morgan, M. A., & Gold, M. H. (1984) · FEBS Letters · doi:10.1016/0014-5793(84)80327-0 · Cited by 797 · see citing works
LIPID PEROXIDATION, OXYGEN RADICALS, CELL DAMAGE, AND ANTIOXIDANT THERAPY
Halliwell, B. B., & Gutteridge, J. C. (1984) · The Lancet · doi:10.1016/s0140-6736(84)91886-5 · Cited by 796 · see citing works
Self-citation
Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.
Nathan, C. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113241 · Cited by 791 · see citing works
Hydroxyl radical production and autoxidative glycosylation. Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing
Hunt, J. V., Dean, R. T., & Wolff, S. P. (1988) · Biochemical Journal · doi:10.1042/bj2560205 · Cited by 779 · see citing works
Oxidases and Related Redox Systems
(1982) · Elsevier eBooks · doi:10.1016/c2013-0-03176-3 · Cited by 768 · see citing works
Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes
Esterbauer, H., Jürgens, G., Quehenberger, O., & Koller, E. (1987) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38678-8 · Cited by 766 · see citing works
Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria.
Freeman, B. Α., & Crapo, J. D. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68544-3 · Cited by 762 · see citing works
Superoxide‐dependent formation of hydroxyl radicals in the presence of iron chelates
Halliwell, B. B. (1978) · FEBS Letters · doi:10.1016/0014-5793(78)80779-0 · Cited by 743 · see citing works
Self-citation
The Pathogenesis of Atherosclerosis: Atherogenesis and Inflammation
Munro, J. M., & Cotran, R. S. (1989) · Humana Press eBooks · doi:10.1007/978-1-4612-4502-5_10 · Cited by 698 · see citing works
Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone.
Bolli, R., Patel, B. S., Jeroudi, M. O., Lai, E. K., & McCay, P. B. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113621 · Cited by 685 · see citing works
Iron transport and storage
Crichton, R. R., & CHARLOTEAUX‐WAUTERS, M. (1987) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1987.tb11155.x · Cited by 682 · see citing works
The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum.
Osaki, S., Johnson, D. A., & Frieden, E. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96527-0 · Cited by 679 · see citing works
Antioxidants in relation to lipid peroxidation
Niki, E. (1987) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(87)90052-1 · Cited by 677 · see citing works
Endothelium-derived relaxing factor
Moncada, S., Radomski, M. W., & Palmer, R. M. J. (1988) · Biochemical Pharmacology · doi:10.1016/0006-2952(88)90236-5 · Cited by 676 · see citing works
A Mechanism for the Production of Ethylene from Methional
Beauchamp, C., & Fridovich, I. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62842-x · Cited by 667 · see citing works
The potential diagram for oxygen at pH 7
Wood, P. M. (1988) · Biochemical Journal · doi:10.1042/bj2530287 · Cited by 652 · see citing works
Evidence that Peroxidation of Lysosomal Membranes Is Initiated by Hydroxyl Free Radicals Produced during Flavin Enzyme Activity
Fong, K.-L., McCay, P. B., Poyer, J. L., Keele, B. B., & Misra, H. P. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43258-4 · Cited by 650 · see citing works
Albumin—An important extracellular antioxidant?
Halliwell, B. B. (1988) · Biochemical Pharmacology · doi:10.1016/0006-2952(88)90126-8 · Cited by 648 · see citing works
Self-citation
Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides
Gutteridge, J. M. C. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)80626-3 · Cited by 629 · see citing works
Self-citation
Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine
Gutteridge, J. M. C., Richmond, R., & Halliwell, B. B. (1979) · Biochemical Journal · doi:10.1042/bj1840469 · Cited by 629 · see citing works
Self-citation
Prevalence of Hemochromatosis among 11,065 Presumably Healthy Blood Donors
Edwards, C. Q., Griffen, L. M., Goldgar, D. E., Drummond, C., Skolnick, M. H., & Kushner, J. P. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805263182103 · Cited by 628 · see citing works
Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy.
Garlick, P. B., Davies, M. J., Hearse, D. J., & Slater, T. F. (1987) · Circulation Research · doi:10.1161/01.res.61.5.757 · Cited by 625 · see citing works
Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products.
Steinbrecher, U. P. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61395-x · Cited by 618 · see citing works
Hemoglobin. A biologic fenton reagent.
Sadrzadeh, S. M. H., Graf, E., Panter, S. S., Hallaway, P. E., & Eaton, J. W. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42604-4 · Cited by 589 · see citing works
The involvement of iron in lipid peroxidation. Importance of ferric to ferrous ratios in initiation.
Braughler, J. M., Duncan, L. A., & Chase, R. L. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67521-0 · Cited by 585 · see citing works
The antioxidant action of taurine, hypotaurine and their metabolic precursors
Aruoma, O. I., Halliwell, B. B., Hoey, B. M., & Butler, J. (1988) · Biochemical Journal · doi:10.1042/bj2560251 · Cited by 580 · see citing works
Self-citation
Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial "stunning" is a manifestation of reperfusion injury.
Bolli, R., Jeroudi, M. O., Patel, B. S., Aruoma, O. I., Halliwell, B. B., Lai, E. K., & McCay, P. B. (1989) · Circulation Research · doi:10.1161/01.res.65.3.607 · Cited by 579 · see citing works
Self-citation
Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin
Laughton, M. J., Halliwell, B. B., Evans, P., Robin, J., & Hoult, S. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90442-5 · Cited by 559 · see citing works
Self-citation
Generation of Superoxide Free Radical during the Autoxidation of Thiols
Misra, H. P. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42810-x · Cited by 556 · see citing works
Electrostatic recognition between superoxide and copper, zinc superoxide dismutase
Getzoff, E. D., Tainer, J. A., Weiner, P. K., Kollman, P. A., Richardson, J. S., & Richardson, D. C. (1983) · Nature · doi:10.1038/306287a0 · Cited by 554 · see citing works
A study of the reactivity of HO2/O2-with unsaturated fatty acids
Bielski, B. H., Arudi, R. L., & Sutherland, M. W. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32488-8 · Cited by 546 · see citing works
The requirement for iron (III) in the initiation of lipid peroxidation by iron (II) and hydrogen peroxide.
Minotti, G., & Aust, S. D. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75755-x · Cited by 544 · see citing works
Lipid peroxidation and cellular damage in toxic liver injury.
Comporti, M. (1985) · PubMed · Cited by 543 · see citing works
Damage of the outer membrane of enteric gram-negative bacteria by lactoferrin and transferrin
Ellison, R. T., Giehl, T. J., & LaForce, F. M. (1988) · Infection and Immunity · doi:10.1128/iai.56.11.2774-2781.1988 · Cited by 540 · see citing works
ADP-activated lipid peroxidation coupled to the TPNH oxidase system of microsomes
Hochstein, P. E., & Ernster, L. (1963) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(63)90111-6 · Cited by 536 · see citing works
Free Radicals, Lipid Peroxidation and Cancer
Butler, J. (1982) · British Journal of Cancer · doi:10.1038/bjc.1982.283 · Cited by 514 · see citing works
Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.
Schraufstätter, I. U., Hinshaw, D. B., Hyslop, P. A., Spragg, R. G., & Cochrane, C. G. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112436 · Cited by 511 · see citing works
Cholesterol Autoxidation
Smith, L. L. (1981) · Springer eBooks · doi:10.1007/978-1-4757-9691-9 · Cited by 499 · see citing works
Production of formaldehyde during metabolism of dimethyl sulfoxide by hydroxyl radical-generating systems
Klein, S. M., Cohen, G., & Cederbaum, A. I. (1981) · Biochemistry · doi:10.1021/bi00524a013 · Cited by 486 · see citing works
Mechanism of the disproportionation of superoxide radicals
Bielski, B. H. J., & Allen, A. O. (1977) · The Journal of Physical Chemistry · doi:10.1021/j100526a005 · Cited by 485 · see citing works
Oxidants and the central nervous system: some fundamental questions. Is oxidant damage relevant to Parkinson's disease, Alzheimer's disease, traumatic injury or stroke?
Halliwell, B. B. (1989) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1989.tb01779.x · Cited by 468 · see citing works
Self-citation
Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. Detection of ‘free’ iron in biological systems by using bleomycin-dependent degradation of DNA
Gutteridge, J. M. C., Rowley, D. A., & Halliwell, B. B. (1981) · Biochemical Journal · doi:10.1042/bj1990263 · Cited by 467 · see citing works
Self-citation
Chemistry of free radical and singlet oxidation of lipids
Frankel, E. N. (1984) · Progress in Lipid Research · doi:10.1016/0163-7827(84)90011-0 · Cited by 465 · see citing works
Plasma levels of antioxidant vitamins in relation to ischemic heart disease and cancer
Gey, K. F., Brubacher, G. B., & Stähelin, H. B. (1987) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/45.5.1368 · Cited by 433 · see citing works
Antioxidant and co-antioxidant activity of vitamin C. The effect of vitamin C, either alone or in the presence of vitamin E or a water-soluble vitamin E analogue, upon the peroxidation of aqueous multilamellar phospholipid liposomes
Doba, T., Burton, G. W., & Ingold, K. U. (1985) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(85)90285-1 · Cited by 428 · see citing works
Oxidative damage, lipid peroxidation and antioxidant protection in chloroplasts
Halliwell, B. B. (1987) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(87)90056-9 · Cited by 422 · see citing works
Self-citation
Non‐Specific Serum Iron in Thalassaemia: an Abnormal Serum Iron Fraction of Potential Toxicity
Hershko, C., Graham, G. M., Bates, G. W., & Rachmilewitz, E. A. (1978) · British Journal of Haematology · doi:10.1111/j.1365-2141.1978.tb03662.x · Cited by 421 · see citing works
Bleomycin‐induced strand‐scission of DNA. Mechanism of deoxyribose cleavage
Giloni, L., Takeshita, M., Johnson, F., Iden, C., & Grollman, A. P. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68888-5 · Cited by 412 · see citing works
Role of Oxygen-Derived Free Radicals in Hemorrhagic Shock-Induced Gastric Lesions in the Rat
Itoh, M., & Guth, P. H. (1985) · Gastroenterology · doi:10.1016/s0016-5085(85)80075-5 · Cited by 410 · see citing works
The role of oxygen-derived free radicals in ischemia-induced increases in canine skeletal muscle vascular permeability.
Korthuis, R. J., Granger, D. N., Townsley, M. I., & Taylor, A. E. (1985) · Circulation Research · doi:10.1161/01.res.57.4.599 · Cited by 407 · see citing works
Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis
Grootveld, M. C., Bell, J. D., Halliwell, B. B., Aruoma, O. I., Bomford, A. B., & Sadler, P. J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83758-9 · Cited by 404 · see citing works
Self-citation
Formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Is haemoglobin a biological Fenton reagent?
Puppo, A., & Halliwell, B. B. (1988) · Biochemical Journal · doi:10.1042/bj2490185 · Cited by 399 · see citing works
Self-citation
Mutagenesis and stress responses induced in Escherichia coli by hydrogen peroxide
Imlay, J. A., & Linn, S. (1987) · Journal of Bacteriology · doi:10.1128/jb.169.7.2967-2976.1987 · Cited by 398 · see citing works
Modification of human serum low density lipoprotein by oxidation — Characterization and pathophysiological implications
Jürgens, G., Hoff, H. F., Chisolm, G. M., & Esterbauer, H. (1987) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(87)90070-3 · Cited by 398 · see citing works
Inactivation of ribonuclease and other enzymes by peroxidizing lipids and by malonaldehyde
Chio, K. S., & Tappel, A. L. (1969) · Biochemistry · doi:10.1021/bi00835a020 · Cited by 398 · see citing works
The oxidizing nature of the hydroxyl radical. A comparison with the ferryl ion (FeO2+)
Koppenol, W. H., & Liebman, J. F. (1984) · The Journal of Physical Chemistry · doi:10.1021/j150645a024 · Cited by 394 · see citing works
Allopurinol and oxypurinol are hydroxyl radical scavengers
Moorhouse, P. C., Grootveld, M. C., Halliwell, B. B., Quinlan, J. G., & Gutteridge, J. M. C. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)81458-8 · Cited by 393 · see citing works
Self-citation
Low molecular weight intracellular iron transport compounds
Jacobs, A. J. (1977) · Blood · doi:10.1182/blood.v50.3.433.433 · Cited by 387 · see citing works
Initiation of lipid peroxidation in biological systems
Kanner, J., German, J. B., Kinsella, J., & Hultin, H. O. (1987) · C R C Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398709527457 · Cited by 382 · see citing works
Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases.
Biemond, P., van Eijk, H. G., Swaak, A. J., & Koster, J. F. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111364 · Cited by 380 · see citing works
Protection against tissue damage in vivo by desferrioxamine: What is its mechanism of action?
Halliwell, B. B. (1989) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(89)90145-7 · Cited by 378 · see citing works
Self-citation
Aromatic hydroxylation as a potential measure of hydroxyl-radical formation in vivo. Identification of hydroxylated derivatives of salicylate in human body fluids
Grootveld, M. C., & Halliwell, B. B. (1986) · Biochemical Journal · doi:10.1042/bj2370499 · Cited by 375 · see citing works
Self-citation
Spin Trapping of Superoxide
Finkelstein, E., Rosen, G. M., Rauckman, E. J., & Paxton, J. (1979) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13797-8 · Cited by 372 · see citing works
Permeation of the erythrocyte stroma by superoxide radical
Lynch, R. E., & Fridovich, I. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30446-5 · Cited by 370 · see citing works
Iron Ion-dependent Modification of Bases in DNA by the Superoxide Radical-generating System Hypoxanthine/Xanthine Oxidase
Aruoma, O. I., Halliwell, B. B., & Dizdaroğlu, M. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51590-8 · Cited by 360 · see citing works
Self-citation
Intracellular mechanisms for the decomposition of a lipid peroxide. I. Decomposition of a lipid peroxide by metal ions, heme compounds, and nucleophiles
O’Brien, P. J. (1969) · Canadian Journal of Biochemistry · doi:10.1139/o69-076 · Cited by 351 · see citing works
Conversion of xanthine dehydrogenase to oxidase in ischemic rat tissues.
Engerson, T. D., McKelvey, T. G., Rhyne, D. B., Boggio, E. B., Snyder, S. J., & Jones, H. P. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112990 · Cited by 350 · see citing works
The Isolation of a Red Protein from Milk2
Groves, M. L. (1960) · Journal of the American Chemical Society · doi:10.1021/ja01498a029 · Cited by 350 · see citing works
Fragmentation of proteins by free radicals and its effect on their susceptibility to enzymic hydrolysis
Wolff, S. P., & Dean, R. T. (1986) · Biochemical Journal · doi:10.1042/bj2340399 · Cited by 349 · see citing works
In vivo formation of single-strand breaks in DNA by hydrogen peroxide is mediated by the Haber-Weiss reaction
Filho, A. C. M., & Meneghini, R. (1984) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(84)90123-4 · Cited by 348 · see citing works
Oxygen-derived free radicals and postischemic myocardial dysfunction (“stunned myocardium”)
Bolli, R. (1988) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(88)90381-6 · Cited by 345 · see citing works
TISSUE FRACTION-PAST AND PRESENT
de Duve, C. (1971) · The Journal of Cell Biology · doi:10.1083/jcb.50.1.20d · Cited by 343 · see citing works
On the participation of higher oxidation states of iron and copper in fenton reactions
Sutton, H. C., & Winterbourn, C. C. (1989) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(89)90160-3 · Cited by 340 · see citing works
Cell killing and DNA damage by hydrogen peroxide are mediated by intracellular iron
Filho, A. C. M., Hoffmann, M. E., & Meneghini, R. (1984) · Biochemical Journal · doi:10.1042/bj2180273 · Cited by 337 · see citing works
The role of lipid peroxidation in liver damage
Poli, G., Albano, E., & Dianzani, M. U. (1987) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(87)90063-6 · Cited by 335 · see citing works
Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent formation and breakdown of hydrogen peroxide during mixed function oxidation reactions in liver microsomes
Hildebrandt, A. G., & Roots, I. (1975) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(75)90047-8 · Cited by 334 · see citing works
Lactoferrin enhances hydroxyl radical production by human neutrophils, neutrophil particulate fractions, and an enzymatic generating system.
Ambruso, D. R., & Johnston, R. B. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110042 · Cited by 334 · see citing works
Generation of free radicals from freshly fractured silica dust. Potential role in acute silica-induced lung injury
Vallyathan, V., Shi, X., Dalal, N. S., Irr, W., & Castranova, V. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/138.5.1213 · Cited by 327 · see citing works
Damage to the Bases in DNA Induced by Hydrogen Peroxide and Ferric Ion Chelates
Aruoma, O. I., Halliwell, B. B., Gajewski, E., & Dizdaroğlu, M. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47091-9 · Cited by 327 · see citing works
Self-citation
Mechanism of Kainate Toxicity to Cerebellar Neurons In Vitro Is Analogous to Reperfusion Tissue Injury
Dykens, J. A., Stern, A., & Trenkner, E. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb10014.x · Cited by 325 · see citing works
The measurement of free radical reactions in humans
Halliwell, B. B., & Grootveld, M. C. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)81455-2 · Cited by 324 · see citing works
Self-citation
Free Radicals, Lipid Peroxidation and Cancer
McBrien, D. C. H., & Slater, T. F. (1982) · Cited by 320 · see citing works
Cholesterol autoxidation 1981–1986
Smith, L. L. (1987) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(87)90046-6 · Cited by 311 · see citing works
Aluminium salts accelerate peroxidation of membrane lipids stimulated by iron salts
Gutteridge, J. M. C., Quinlan, G. J., Clark, I. A., & Halliwell, B. B. (1985) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(85)90113-4 · Cited by 311 · see citing works
Self-citation
Mechanism of DNA cleavage induced by sodium chromate(VI) in the presence of hydrogen peroxide.
Kawanishi, S., Inoue, S., & Sano, S. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38476-4 · Cited by 310 · see citing works
Superoxide anion permeability of phospholipid membranes and chloroplast thylakoids
Takahashi, M., & Asada, K. (1983) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(83)90325-9 · Cited by 309 · see citing works
Tissue fraction-past and present.
Duve, C. D. (1971) · PubMed Central · Cited by 309 · see citing works
Reactivity of hydroxyl and hydroxyl-like radicals discriminated by release of thiobarbituric acid-reactive material from deoxy sugars, nucleosides and benzoate
Gutteridge, J. M. C. (1984) · Biochemical Journal · doi:10.1042/bj2240761 · Cited by 306 · see citing works
Self-citation
Free radicals and myocardial ischemia and reperfusion injury.
Simpson, P. J., & Lucchesi, B. R. (1987) · PubMed · Cited by 302 · see citing works
Isolation of an Iron-Containing Red Protein from Human Milk.
Johanson, B., Virtanen, A. I., Tweit, R. C., & Dodson, R. M. (1960) · Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry · doi:10.3891/acta.chem.scand.14-0510 · Cited by 301 · see citing works
Superoxide‐dependent formation of hydroxyl radicals in the presence of iron salts
Halliwell, B. B. (1978) · FEBS Letters · doi:10.1016/0014-5793(78)80409-8 · Cited by 299 · see citing works
Self-citation
Enzymatic modification of low density lipoprotein by purified lipoxygenase plus phospholipase A2 mimics cell-mediated oxidative modification
Sparrow, C. P., Parthasarathy, S., & Steinberg, D. H. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38493-5 · Cited by 299 · see citing works
Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats.
Walker, P. D., & Shah, S. V. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113325 · Cited by 298 · see citing works
Production of hydroxyl radical by decomposition of superoxide spin-trapped adducts.
Finkelstein, E., Rosen, G. M., & Rauckman, E. J. (1982) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)14604-x · Cited by 298 · see citing works
Effects of the 21-aminosteroid U74006F on experimental head injury in mice
Hall, E. D., Yonkers, P. A., McCall, J. M., & Braughler, J. M. (1988) · Journal of neurosurgery · doi:10.3171/jns.1988.68.3.0456 · Cited by 295 · see citing works
Lignin synthesis: The generation of hydrogen peroxide and superoxide by horseradish peroxidase and its stimulation by manganese (II) and phenols
Halliwell, B. B. (1978) · Planta · doi:10.1007/bf00389384 · Cited by 289 · see citing works
Self-citation
Antioxidant protection by haemopexin of haem-stimulated lipid peroxidation
Gutteridge, J. M. C., & Smith, A. (1988) · Biochemical Journal · doi:10.1042/bj2560861 · Cited by 286 · see citing works
Self-citation
Thiobarbituric acid‐reactivity following iron‐dependent free‐radical damage to amino acids and carbohydrates
Gutteridge, J. M. C. (1981) · FEBS Letters · doi:10.1016/0014-5793(81)80113-5 · Cited by 284 · see citing works
Self-citation
Role of oxygen radicals in ischemia-induced lesions in the cat stomach
Perry, M. A., WADHWA, S. S., Parks, D. A., et al. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90933-9 · Cited by 283 · see citing works
The primary localization of free radical generation after anoxia/reoxygenation in isolated endothelial cells.
Ratych, R. E., Chuknyiska, R. S., & Bulkley, G. B. (1987) · PubMed · Cited by 283 · see citing works
Superoxide‐dependent formation of hydroxyl radicals in the presence of iron salts
Flitter, W. D., Rowley, D. A., & Halliwell, B. B. (1983) · FEBS Letters · doi:10.1016/0014-5793(83)80602-4 · Cited by 281 · see citing works
Self-citation
Influence of Acidosis on Lipid Peroxidation in Brain Tissues in vitro
Siesjö, B. K., Bendek, G., Koide, T., et al. (1985) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1985.32 · Cited by 280 · see citing works
Generation of Hydroxyl Radical by Enzymes, Chemicals, and Human Phagocytes In Vitro
Repine, J. E., Eaton, J. W., Anders, M. W., Hoidal, J. R., & Fox, R. B. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109626 · Cited by 280 · see citing works
The production of free radicals during the autoxidation of cysteine and their effect on isolated rat hepatocytes
Sáez, G. T., Thornalley, P. J., Hill, H. A. O., Hems, R., & Bannister, J. V. (1982) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(82)90302-6 · Cited by 279 · see citing works
Lipid peroxide formation in microsomes. The role of non-haem iron
Wills, E. D. (1969) · Biochemical Journal · doi:10.1042/bj1130325 · Cited by 274 · see citing works
Doxorubicin-dependent lipid peroxidation at low partial pressures of O2
Winterbourn, C. C., Gutteridge, J. M. C., & Halliwell, B. B. (1985) · Journal of Free Radicals in Biology & Medicine · doi:10.1016/0748-5514(85)90028-5 · Cited by 272 · see citing works
Self-citation
The role of iron in the initiation of lipid peroxidation
Minotti, G., & Aust, S. D. (1987) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(87)90050-8 · Cited by 272 · see citing works
Oxidants, inflammation, and anti‐inflammatory drugs
Halliwell, B. B., Hoult, J. R. S., & Blake, D. R. (1988) · The FASEB Journal · doi:10.1096/fasebj.2.13.2844616 · Cited by 271 · see citing works
Self-citation
Ferrous-salt-promoted damage to deoxyribose and benzoate. The increased effectiveness of hydroxyl-radical scavengers in the presence of EDTA
Gutteridge, J. M. C. (1987) · Biochemical Journal · doi:10.1042/bj2430709 · Cited by 271 · see citing works
Self-citation
Low-molecular-weight iron complexes and oxygen radical reactions in idiopathic haemochromatosis
Gutteridge, J. M. C., Rowley, D. A., Griffiths, E., & Halliwell, B. B. (1985) · Clinical Science · doi:10.1042/cs0680463 · Cited by 269 · see citing works
Self-citation
Comparison of superoxide with other reducing agents in the biological production of hydroxyl radicals
Winterbourn, C. C. (1979) · Biochemical Journal · doi:10.1042/bj1820625 · Cited by 266 · see citing works
IDENTIFICATION OF MICROMETASTASIS OF BREAST CARCINOMAS BY PRESENCE OF BASEMENT MEMBRANE COLLAGEN
Liotta, L. A., Foidart, J., Robey, P. G., et al. (1979) · The Lancet · doi:10.1016/s0140-6736(79)90024-2 · Cited by 261 · see citing works
A Global View of Human Selenium Nutrition
Levander, O. A. (1987) · Annual Review of Nutrition · doi:10.1146/annurev.nu.07.070187.001303 · Cited by 260 · see citing works
Methods for the Measurement of Hydroxyl Radicals in Biochemical Systems: Deoxyribose Degradation and Aromatic Hydroxylation
Halliwell, B. B., Grootveld, M. C., & Gutteridge, J. M. C. (1988) · Methods of biochemical analysis · doi:10.1002/9780470110546.ch2 · Cited by 259 · see citing works
Self-citation
Xanthine oxidase inhibitors attenuate ischemia-induced vascular permeability changes in the cat intestine
Granger, D. N., McCord, J. M., Parks, D. A., & Höllwarth, M. E. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90078-8 · Cited by 257 · see citing works
Chronic Granulomatous Disease
Tauber, A. I., Borregaard, N., Simons, E. R., & Wright, J. (1983) · Medicine · doi:10.1097/00005792-198309000-00003 · Cited by 257 · see citing works
Oxygen Radicals and Tissue Injury
(1997) · Inflammation Research · doi:10.1007/bf03354123 · Cited by 257 · see citing works
Aldehydes in biological systems
Schauenstein, E. (1977) · Cited by 257 · see citing works
Evaluation of an isoluminol chemiluminescence assay for the detection of hydroperoxides in human blood plasma
Frei, B. B., Yamamoto, Y., Niclas, D., & Ames, B. N. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90369-7 · Cited by 255 · see citing works
Inhibition of lipid peroxidation by the iron-binding protein lactoferrin
Gutteridge, J. M. C., Paterson, S., Segal, A. W., & Halliwell, B. B. (1981) · Biochemical Journal · doi:10.1042/bj1990259 · Cited by 252 · see citing works
Self-citation
Oxy-radicals in molecular biology and pathology
(1989) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(89)90343-9 · Cited by 252 · see citing works
Reactions of low-valent transition-metal complexes with hydrogen peroxide. Are they "Fenton-like" or not? 1. The case of Cu+aq and Cr2+aq
Masarwa, M., Cohen, H., Meyerstein, D., Hickman, D. L., Bakač, A., & Espenson, J. H. (1988) · Journal of the American Chemical Society · doi:10.1021/ja00221a031 · Cited by 249 · see citing works
Hydroxyl radical production in body fluids Roles of metal ions, ascorbate and superoxide
Winterbourn, C. C. (1981) · Biochemical Journal · doi:10.1042/bj1980125 · Cited by 249 · see citing works
Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Are lactoferrin and transferrin promoters of hydroxyl-radical generation?
Aruoma, O. I., & Halliwell, B. B. (1987) · Biochemical Journal · doi:10.1042/bj2410273 · Cited by 248 · see citing works
Self-citation
alpha, beta-Dihydroxyisovalerate dehydratase. A superoxide-sensitive enzyme.
Kuo, C. F., Mashino, T., & Fridovich, I. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61255-4 · Cited by 247 · see citing works
Estimates of iron sufficiency in the US population
Cook, J., SKIKNE, B. S., Lynch, S., & Reusser, M. (1986) · Blood · doi:10.1182/blood.v68.3.726.726 · Cited by 246 · see citing works
Cigarette smoke induces DNA single-strand breaks in human cells
Nakayama, T., Kaneko, M., Kodama, M., et al. (1985) · Nature · doi:10.1038/314462a0 · Cited by 245 · see citing works
Copper salt-dependent hydroxyl radical formation
Gutteridge, J. M. C., & Wilkins, S. (1983) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(83)90186-1 · Cited by 243 · see citing works
Self-citation
Regional lipid peroxidation in rat brain in vitro: Possible role of endogenous iron
Zaleska, M. M., & Floyd, R. A. (1985) · Neurochemical Research · doi:10.1007/bf00964608 · Cited by 243 · see citing works
Site-specific Oxidative DNA Damage at Polyguanosines Produced by Copper Plus Hydrogen Peroxide
Sagripant, J. L., & Kraemer, K. H. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94247-x · Cited by 240 · see citing works
Unusual copper-induced sensitization of the biological damage due to superoxide radicals.
Samuni, A. M., Chevion, M., & Czapski, G. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42937-7 · Cited by 239 · see citing works
The State of Copper in Human Serum: Evidence for an Amino Acid-bound Fraction *
Neumann, P. Z., & Sass-Kortsāk, A. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105566 · Cited by 238 · see citing works
Role of oxygen free radicals in shock, ischemia, and organ preservation.
Parks, D. A., Bulkley, G. B., & Granger, D. N. (1983) · PubMed · Cited by 236 · see citing works
New mechanism for glomerular injury. Myeloperoxidase-hydrogen peroxide-halide system.
Johnson, R. J., Couser, W. G., Chi, E. Y., et al. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112965 · Cited by 235 · see citing works
ANTIOXIDANT PROTECTION: A FUNCTION OF TRACHEOBRONCHIAL AND GASTROINTESTINAL MUCUS
Cross, C. E., Halliwell, B. B., & Allen, A. (1984) · The Lancet · doi:10.1016/s0140-6736(84)91822-1 · Cited by 234 · see citing works
Self-citation
Reactive oxygen species during ischemia-reflow injury in isolated perfused rat liver.
Jaeschke, H., Smith, C. V., & Mitchell, J. R. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113441 · Cited by 231 · see citing works
Oxygen Free Radical Induced Damage in Kidneys Subjected to Warm Ischemia and Reperfusion
Baker, G. L., Corry, R. J., & Autor, A. P. (1985) · Annals of Surgery · doi:10.1097/00000658-198511000-00016 · Cited by 230 · see citing works
RAISED CEREBROSPINAL-FLUID COPPER CONCENTRATION IN PARKINSON'S DISEASE
Pall, H., Blake, D. R., Gutteridge, J. M. C., Williams, A. C., Lunec, J., Hall, M., & Taylor, A. (1987) · The Lancet · doi:10.1016/s0140-6736(87)90827-0 · Cited by 230 · see citing works
Self-citation
Superoxide-dependent formation of hydroxyl radicals: Detection of hydroxyl radicals by the hydroxylation of aromatic compounds
Richmond, R., Halliwell, B. B., Chauhan, J., & Darbre, A. (1981) · Analytical Biochemistry · doi:10.1016/0003-2697(81)90590-x · Cited by 230 · see citing works
Self-citation
Lipid peroxidation in rheumatoid arthritis: Thiobarbituric acid-reactive material and catalytic iron salts in synovial fluid from rheumatoid patients
Rowley, D. A., Gutteridge, J. M. C., Blake, D. R., Farrs, M., & Halliwell, B. B. (1984) · Clinical Science · doi:10.1042/cs0660691 · Cited by 225 · see citing works
Self-citation
Free radical metabolite of uric acid.
Maples, K. R., & Mason, R. P. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77933-2 · Cited by 223 · see citing works
Role of iron in postischemic renal injury in the rat
Paller, M. S., Hedlund, B. E., Sikora, J. J., Faassen, A., & Waterfield, R. (1988) · Kidney International · doi:10.1038/ki.1988.205 · Cited by 222 · see citing works
Action of lead(II) and aluminium(III) ions on iron-stimulated lipid peroxidation in liposomes, erythrocytes and rat liver microsomal fractions
Quinlan, G. J., Halliwell, B. B., Moorhouse, C. P., & Gutteridge, J. M. C. (1988) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(88)90159-2 · Cited by 221 · see citing works
Self-citation
Superoxide-dependent formation of hydroxyl radicals and lipid peroxidation in the presence of iron salts. Detection of ‘catalytic’ iron and anti-oxidant activity in extracellular fluids
Gutteridge, J. M. C., Rowley, D. A., & Halliwell, B. B. (1982) · Biochemical Journal · doi:10.1042/bj2060605 · Cited by 217 · see citing works
Self-citation
Caeruloplasmin: Physiological and Pathological Perspectives
Gutteridge, J. M. C., & Stocks, J. (1981) · CRC Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408368109105866 · Cited by 217 · see citing works
Self-citation
Intra- and extracellular events in luminol-dependent chemiluminescence of polymorphonuclear leukocytes
Briheim, G., Stendahl, O. I., & Dahlgren, C. (1984) · Infection and Immunity · doi:10.1128/iai.45.1.1-5.1984 · Cited by 214 · see citing works
THE QUENCHING OF SINGLET OXYGEN BY AMINO ACIDS AND PROTEINS
Matheson, I. B. C., Etheridge, R. D., Kratowich, N., & Lee, J. (1975) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1975.tb06647.x · Cited by 214 · see citing works
Superoxide‐dependent formation of hydroxyl radicals in the presence of thiol compounds
Rowley, D. A., & Halliwell, B. B. (1982) · FEBS Letters · doi:10.1016/0014-5793(82)80388-8 · Cited by 213 · see citing works
Self-citation
Site-specific modification of albumin by free radicals. Reaction with copper(II) and ascorbate
Marx, G. S., & Chevion, M. (1986) · Biochemical Journal · doi:10.1042/bj2360397 · Cited by 212 · see citing works
Consequences of cadmium toxicity in rat hepatocytes: Mitochondrial dysfunction and lipid peroxidation
Müller, L. (1986) · Toxicology · doi:10.1016/0300-483x(86)90061-2 · Cited by 211 · see citing works
The mechanism of initiation of lipid peroxidation. Evidence against a requirement for an iron(II)-iron(III) complex
Aruoma, O. I., Halliwell, B. B., Laughton, M. J., Quinlan, G. J., & Gutteridge, J. M. C. (1989) · Biochemical Journal · doi:10.1042/bj2580617 · Cited by 210 · see citing works
Self-citation
Xanthine oxidase-derived hydrogen peroxide contributes to ischemia reperfusion-induced edema in gerbil brains.
Patt, A., Harken, A. H., Burton, L. K., Rodell, T. C., Piermattei, D., Schorr, W., Parker, N. B., Berger, E. M., Horesh, I. R., & Terada, L. S. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113488 · Cited by 209 · see citing works
Excitatory Amino Acid Release from Rat Hippocampal Slices as a Consequence of Free‐Radical Formation
Pellegrini-Giampietro, D. E., Cherici, G., Alesiani, M., Carlà, V., & Moroni, F. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb01187.x · Cited by 206 · see citing works
The Toxicology of Molecular Oxygen
Diguiseppi, J., Fridovich, I., & McCord, J. M. (1984) · Critical Reviews in Toxicology · doi:10.3109/10408448409044213 · Cited by 205 · see citing works
Singlet oxygen production by human eosinophils.
Kanofsky, J. R., Hoogland, H., Wever, R., & Weiss, S. J. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81573-9 · Cited by 203 · see citing works
Evidence for superoxide-dependent reduction of Fe3+ and its role in enzyme-generated hydroxyl radical formation
Fong, K.-L., McCay, P. B., Poyer, J. L., et al. (1976) · Chemico-Biological Interactions · doi:10.1016/0009-2797(76)90130-7 · Cited by 201 · see citing works
Regulation of hydrogen peroxide in eye humors effect of 3-amino-1H-1,2,4-triazole on catalase and glutathione peroxidase of rabbit eye
Bhuyan, K. C., & Bhuyan, D. K. (1977) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(77)90284-7 · Cited by 201 · see citing works
Oxidizing intermediates in the reaction of ferrous EDTA with hydrogen peroxide. Reactions with organic molecules and ferrocytochrome c.
Rush, J. D., & Koppenol, W. H. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)62677-3 · Cited by 200 · see citing works
Determination of malonaldehyde in biological materials by high-pressure liquid chromatography
Bird, R. P., Hung, S. S. O., Hadley, M., et al. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90371-8 · Cited by 200 · see citing works
Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals in the presence of copper salts: A physiologically significant reaction?
Rowley, D. A., & Halliwell, B. B. (1983) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(83)90031-0 · Cited by 199 · see citing works
Self-citation
Ascorbic acid, metal ions and the superoxide radical
Halliwell, B. B., & Foyer, C. H. (1976) · Biochemical Journal · doi:10.1042/bj1550697 · Cited by 195 · see citing works
Self-citation
Free-radical damage to lipids, amino acids, carbohydrates and nucleic acids determined by thiobarbituric acid reactivity
Gutteridge, J. M. C. (1982) · International Journal of Biochemistry · doi:10.1016/0020-711x(82)90050-7 · Cited by 192 · see citing works
Self-citation
Biologically significant scavenging of the myeloperoxidase‐derived oxidant hypochlorous acid by ascorbic acid
Halliwell, B., Wasil, M., & Grootveld, M. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)81456-4 · Cited by 189 · see citing works
Self-citation
Pulse Radiolytic Study of the Interaction of Thiols and Ascorbate with OH Adducts of dGMP and dG: Implications for DNA Repair Processes
O'Neill, P. (1983) · Radiation Research · doi:10.2307/3576178 · Cited by 188 · see citing works
The Inhibition of Lipid Autoxidation by Human Serum and its Relation to Serum Proteins and α-Tocopherol
Stocks, J., Gutteridge, J. M. C., Sharp, R. J., & Dormandy, T. L. (1974) · Clinical Science · doi:10.1042/cs0470223 · Cited by 187 · see citing works
Self-citation
Biochemical and Clinical Aspects of Oxygen
(1979) · Elsevier eBooks · doi:10.1016/b978-0-121-64380-5.x5001-4 · Cited by 186 · see citing works

Flagged first, then by citations

Sorted by citations

Free radicals, metals and antioxidants in oxidative stress-induced cancer
Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680 · see citing works
Oxidative mechanisms in the toxicity of metal ions
Stohs, S. J., & Bagchi, D. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00159-h · Cited by 4,219 · see citing works
Heavy metals, occurrence and toxicity for plants: a review
Nagajyoti, P. C., Lee, K. D., & Sreekanth, T. V. M. (2010) · Environmental Chemistry Letters · doi:10.1007/s10311-010-0297-8 · Cited by 3,962 · see citing works
Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options
Uttara, B., Singh, A., Zamboni, P., & Mahajan, R. (2009) · Current Neuropharmacology · doi:10.2174/157015909787602823 · Cited by 3,378 · see citing works
Reactive Oxygen Species and the Central Nervous System
Halliwell, B. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10990.x · Cited by 2,947 · see citing works
Self-citation
Oxidative stress and neurodegeneration: where are we now?
Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614 · see citing works
Self-citation
Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
Antioxidants and antioxidant methods: an updated overview
Gulcin, İ. (2020) · Archives of Toxicology · doi:10.1007/s00204-020-02689-3 · Cited by 2,205 · see citing works
The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration
Beatty, S., Koh, H.-H., Phil, M., Henson, D., & Boulton, M. (2000) · Survey of Ophthalmology · doi:10.1016/s0039-6257(00)00140-5 · Cited by 2,051 · see citing works
Free radicals, oxidative stress, and antioxidants in human health and disease
Aruoma, O. I. (1998) · Journal of the American Oil Chemists' Society · doi:10.1007/s11746-998-0032-9 · Cited by 1,682 · see citing works
Role of Free Radicals in the Neurodegenerative Diseases: Therapeutic Implications for Antioxidant Treatment
Halliwell, B. (2001) · Drugs & Aging · doi:10.2165/00002512-200118090-00004 · Cited by 1,502 · see citing works
Self-citation
Role of oxidative stress in cardiovascular diseases
Dhalla, N. S., Temsah, R. M., & Netticadan, T. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018060-00002 · Cited by 1,467 · see citing works
High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men
Salonen, J. T., Nyyssönen, K., Korpela, H., Tuomilehto, J., Seppänen, R., & Salonen, R. (1992) · Circulation · doi:10.1161/01.cir.86.3.803 · Cited by 1,284 · see citing works
Mitochondria and reactive oxygen species
Kowaltowski, A. J., de Souza-Pinto, N. C., Castilho, R. F., & Vercesi, A. E. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.004 · Cited by 1,162 · see citing works
Hydrogen peroxide in the human body
Halliwell, B., Clement, M. V., & Long, L. H. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02197-9 · Cited by 1,075 · see citing works
Self-citation
Iron metabolism and toxicity
Papanikolaou, G., & Pantopoulos, K. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.06.021 · Cited by 1,070 · see citing works
Heme oxygenase 1 is required for mammalian iron reutilization
Poss, K. D., & Tonegawa, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10919 · Cited by 1,016 · see citing works
Obstructive sleep apnoea syndrome – an oxidative stress disorder
Lavie, L. (2003) · Sleep Medicine Reviews · doi:10.1053/smrv.2002.0261 · Cited by 993 · see citing works
Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury
Mori, K., Lee, H. T., Rapoport, D., Drexler, I. R., Foster, K., Yang, J., Schmidt-Ott, K. M., Chen, X., Li, J. Y., Weiss, S., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23056 · Cited by 954 · see citing works
Mitochondrial damage induced by conditions of oxidative stress
Kowaltowski, A. J., & Vercesi, A. E. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00216-0 · Cited by 866 · see citing works
Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions
Catalá, A. (2009) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2008.09.004 · Cited by 745 · see citing works
Antioxidants in wild mushrooms
Ferreira, I., Barros, L., & Abreu, R. (2009) · Current Medicinal Chemistry · doi:10.2174/092986709787909587 · Cited by 670 · see citing works
Oxidative stress in autism
Chauhan, A., & Chauhan, V. (2006) · Pathophysiology · doi:10.1016/j.pathophys.2006.05.007 · Cited by 656 · see citing works
Fenton Chemistry: An Introduction
Wardman, P., & Candeias, L. P. (1996) · Radiation Research · doi:10.2307/3579270 · Cited by 587 · see citing works
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works
Labile plasma iron in iron overload: redox activity and susceptibility to chelation
Esposito, B. P., Breuer, W., Sirankapracha, P., Pootrakul, P., Hershko, C., & Cabantchik, Z. I. (2003) · Blood · doi:10.1182/blood-2003-03-0807 · Cited by 475 · see citing works
The wanderings of a free radical
Halliwell, B. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.11.008 · Cited by 467 · see citing works
Self-citation
Stimulation of lipid peroxidation and hydroxyl-radical generation by the contents of human atherosclerotic lesions
Smith, C., Mitchinson, M. J., Aruoma, O. I., & Halliwell, B. (1992) · Biochemical Journal · doi:10.1042/bj2860901 · Cited by 455 · see citing works
Self-citation
Cytokine Production by Human Airway Epithelial Cells after Exposure to an Air Pollution Particle Is Metal-Dependent
Carter, J. D., Ghio, A. J., Samet, J. M., & Devlin, R. B. (1997) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1997.8254 · Cited by 449 · see citing works
O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate
Schoenfeld, J. D., Sibenaller, Z. A., Mapuskar, K. A., Wagner, B. A., Cramer-Morales, K. L., Furqan, M., Sandhu, S., Carlisle, T. L., Smith, M. C., Abu Hejleh, T., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.02.018 · Cited by 443 · see citing works
Mannitol Protects against Oxidation by Hydroxyl Radicals
Shen, B., Jensen, R. G., & Bohnert, H. J. (1997) · Plant Physiology · doi:10.1104/pp.115.2.527 · Cited by 422 · see citing works
The Role of Iron in Diabetes and Its Complications
Swaminathan, S., Fonseca, V. A., Alam, M. G., & Shah, S. V. (2007) · Diabetes Care · doi:10.2337/dc06-2625 · Cited by 423 · see citing works
Antioxidants: Molecules, medicines, and myths
Gutteridge, J. M. C., & Halliwell, B. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.071 · Cited by 405 · see citing works
Self-citation
Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress
Katiyar, S. K., Afaq, F., Perez, A., & Mukhtar, H. (2001) · Carcinogenesis · doi:10.1093/carcin/22.2.287 · Cited by 399 · see citing works
Oxidative stress and peritoneal endometriosis
Van Langendonckt, A., Casanas-Roux, F., & Donnez, J. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)02959-x · Cited by 391 · see citing works
Laboratory evolution of copper tolerant yeast strains
Adamo, G. M., Brocca, S., Passolunghi, S., Salvato, B., & Lotti, M. (2012) · Microbial Cell Factories · doi:10.1186/1475-2859-11-1 · Cited by 392 · see citing works
Oxidative stress in the pathology and treatment of systemic lupus erythematosus
Perl, A. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.147 · Cited by 358 · see citing works
ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage
Barzilai, A. (2002) · DNA Repair · doi:10.1016/s1568-7864(01)00007-6 · Cited by 359 · see citing works
Intracellular Copper Does Not Catalyze the Formation of Oxidative DNA Damage in Escherichia coli
Macomber, L., Rensing, C., & Imlay, J. A. (2007) · Journal of Bacteriology · doi:10.1128/jb.01357-06 · Cited by 356 · see citing works
Delayed production of free radicals following noise exposure
Yamashita, D., Jiang, H.-Y., Schacht, J., & Miller, J. M. (2004) · Brain Research · doi:10.1016/j.brainres.2004.05.104 · Cited by 352 · see citing works
Quantification of F2-isoprostanes as a biomarker of oxidative stress
Milne, G. L., Sanchez, S. C., Musiek, E. S., & Morrow, J. D. (2007) · Nature Protocols · doi:10.1038/nprot.2006.375 · Cited by 333 · see citing works
Caffeine as an Antioxidant: Inhibition of Lipid Peroxidation Induced by Reactive Oxygen Species
Devasagayam, T. P. A., Kamat, J. P., Mohan, H., & Kesavan, P. C. (1996) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(96)00040-5 · Cited by 331 · see citing works
Mitochondrial oxidative stress after carbon monoxide hypoxia in the rat brain.
Zhang, J., & Piantadosi, C. A. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115980 · Cited by 320 · see citing works
Modification of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Formation of cross-linked protein that inhibits the multicatalytic protease.
Friguet, B., Stadtman, E. R., & Szweda, L. I. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31853-7 · Cited by 311 · see citing works
Melatonin, endocrine pancreas and diabetes
Peschke, E. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00519.x · Cited by 309 · see citing works
Mortality from different causes associated with meat, heme iron, nitrates, and nitrites in the NIH-AARP Diet and Health Study: population based cohort study
Etemadi, A., Sinha, R., Ward, M. H., Graubard, B. I., Inoue-Choi, M., Dawsey, S. M., & Abnet, C. C. (2017) · BMJ · doi:10.1136/bmj.j1957 · Cited by 296 · see citing works
Oxidative stress of the newborn in the pre‐ and postnatal period and the clinical utility of melatonin
Gitto, E., Pellegrino, S., Gitto, P., Barberi, I., & Reiter, R. J. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00649.x · Cited by 291 · see citing works
Interaction of Iron with Polyphenolic Compounds: Application to Antioxidant Characterization
Yoshino, M., & Murakami, K. (1998) · Analytical Biochemistry · doi:10.1006/abio.1997.2522 · Cited by 291 · see citing works
Superoxide Dismutases in Candida albicans : Transcriptional Regulation and Functional Characterization of the Hyphal-induced SOD5 Gene
Martchenko, M., Alarco, A.-M., Harcus, D., & Whiteway, M. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-03-0179 · Cited by 290 · see citing works
Copper in Microbial Pathogenesis: Meddling with the Metal
Samanovic, M. I., Ding, C., Thiele, D. J., & Darwin, K. H. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.01.009 · Cited by 278 · see citing works
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species
Juntilla, M. M., Patil, V. D., Calamito, M., Joshi, R. P., Birnbaum, M. J., & Koretzky, G. A. (2010) · Blood · doi:10.1182/blood-2009-09-241000 · Cited by 284 · see citing works
Elevation of Mitochondrial Transmembrane Potential and Reactive Oxygen Intermediate Levels Are Early Events and Occur Independently from Activation of Caspases in Fas Signaling
Banki, K., Hutter, E., Gonchoroff, N. J., & Perl, A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.3.1466 · Cited by 276 · see citing works
Tannin−Protein Complexes as Radical Scavengers and Radical Sinks
Riedl, K. M., & Hagerman, A. E. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010683h · Cited by 262 · see citing works
Role of 4-hydroxy-2-nonenal (HNE) in the pathogenesis of alzheimer disease and other selected age-related neurodegenerative disorders
Di Domenico, F., Tramutola, A., & Butterfield, D. A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.490 · Cited by 253 · see citing works
Synthetic and natural iron chelators: Therapeutic potential and clinical use
Hatcher, H. C., Singh, R. N., Torti, F. M., & Torti, S. V. (2009) · Future Medicinal Chemistry · doi:10.4155/fmc.09.121 · Cited by 242 · see citing works
4-Hydroxynonenal in the Pathogenesis and Progression of Human Diseases
Shoeb, M., Ansari, N., Srivastava, S., & Ramana, K. (2013) · Current Medicinal Chemistry · doi:10.2174/09298673113209990181 · Cited by 230 · see citing works
Body Iron Stores and Heme-Iron Intake in Relation to Risk of Type 2 Diabetes: A Systematic Review and Meta-Analysis
Zhao, Z., Li, S., Liu, G., Yan, F., Ma, X., Huang, Z., & Tian, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041641 · Cited by 227 · see citing works
On the expression of nitric oxide synthase by human macrophages. Why no NO?
Albina, J. E. (1995) · Journal of Leukocyte Biology · doi:10.1002/jlb.58.6.643 · Cited by 213 · see citing works
Purification of novel anti-inflammatory peptides from enzymatic hydrolysate of the edible microalgal Spirulina maxima
Vo, T.-S., Ryu, B., & Kim, S.-K. (2013) · Journal of Functional Foods · doi:10.1016/j.jff.2013.05.001 · Cited by 209 · see citing works
The Effects of Intravenous Antioxidants in Patients With Septic Shock
Galley, H. F., Howdle, P. D., Walker, B. E., & Webster, N. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00059-2 · Cited by 203 · see citing works
Ascorbyl radical formation in patients with sepsis: Effect of ascorbate loading
Galley, H. F., Davies, M. J., & Webster, N. R. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02022-5 · Cited by 199 · see citing works
Autocrine production of extracellular catalase prevents apoptosis of the human CEM T-cell line in serum-free medium.
Sandstrom, P. A., & Buttke, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4708 · Cited by 186 · see citing works
In VitroMethods of Assay of Antioxidants: An Overview
Singh, S., & Singh, R. P. (2008) · Food Reviews International · doi:10.1080/87559120802304269 · Cited by 182 · see citing works
Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence
Ding, C., Festa, R. A., Chen, Y.-L., Espart, A., Palacios, Ò., Espín, J., Capdevila, M., Atrian, S., Heitman, J., & Thiele, D. J. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.02.002 · Cited by 179 · see citing works
Antioxidant protection against organic and inorganic oxygen radicals by normal human plasma: the important primary role for iron-binding and iron-oxidising proteins
Gutteridge, J. M. C., & Quinlan, G. J. (1992) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(92)90052-f · Cited by 148 · see citing works
Self-citation
Abnormal T cell signal transduction in systemic lupus erythematosus
Kammer, G. M., Perl, A., Richardson, B. C., & Tsokos, G. C. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10192 · Cited by 139 · see citing works
Recent developments in copper and zinc homeostasis in bacterial pathogens
Braymer, J. J., & Giedroc, D. P. (2014) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2013.12.021 · Cited by 126 · see citing works
Submicromolar hydrogen peroxide disrupts the ability of Fur protein to control free‐iron levels in Escherichia coli
Varghese, S., Wu, A., Park, S., Imlay, K. R. C., & Imlay, J. A. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05701.x · Cited by 133 · see citing works
Iron and 8-isoprostane levels in acute and chronic wounds
Yeoh-Ellerton, S., & Stacey, M. C. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12471.x · Cited by 125 · see citing works
Peritoneal endometriosis is an inflammatory disease
Donnez, J. (2012) · Frontiers in Bioscience · doi:10.2741/e358 · Cited by 127 · see citing works
Alterations in Plasma Essential Trace Elements Selenium, Manganese, Zinc, Copper, and Iron Concentrations and the Possible Role of these Elements on Oxidative Status in Patients with Childhood Asthma
Kocyigit, A., Armutcu, F., Gurel, A., & Ermis, B. (2004) · Biological Trace Element Research · doi:10.1385/bter:97:1:31 · Cited by 120 · see citing works
Assessment of Chelatable Mitochondrial Iron by Using Mitochondrion‐Selective Fluorescent Iron Indicators with Different Iron‐Binding Affinities
Rauen, U., Springer, A., Weisheit, D., Petrat, F., Korth, H., de Groot, H., & Sustmann, R. (2007) · ChemBioChem · doi:10.1002/cbic.200600311 · Cited by 121 · see citing works
Increased Lipid Peroxidation in Pregnant Women after Iron and Vitamin C Supplementation
Lachili, B., Hininger, I., Faure, H., Arnaud, J., Richard, M.-J., Favier, A., & Roussel, A.-M. (2001) · Biological Trace Element Research · doi:10.1385/bter:83:2:103 · Cited by 116 · see citing works
Heme and FLVCR-related transporter families SLC48 and SLC49
Khan, A. A., & Quigley, J. G. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.07.013 · Cited by 105 · see citing works
The impact of ω-3 fatty acids, vitamins E and C supplementation on treatment outcome and side effects in schizophrenia patients treated with haloperidol: An open-label pilot study
Sivrioglu, E. Y., Kirli, S., Sipahioglu, D., Gursoy, B., & Sarandöl, E. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.07.004 · Cited by 102 · see citing works
Relocalized redox-active lysosomal iron is an important mediator of oxidative-stress-induced DNA damage
KURZ, T., LEAKE, A., von ZGLINICKI, T., & BRUNK, U. T. (2004) · Biochemical Journal · doi:10.1042/bj20031029 · Cited by 101 · see citing works
Current Thinking on the Pathogenesis of Endometriosis
Donnez, J., van Langendonckt, A., Casanas-Roux, F., van Gossum, J.-P., Pirard, C., Jadoul, P., Squifflet, J., & Smets, M. (2002) · Gynecologic and Obstetric Investigation · doi:10.1159/000066295 · Cited by 100 · see citing works
Hormonal suppression treatment or dietary therapy versus placebo in the control of painful symptoms after conservative surgery for endometriosis stage III–IV. A randomized comparative trial
Sesti, F., Pietropolli, A., Capozzolo, T., Broccoli, P., Pierangeli, S., Bollea, M. R., & Piccione, E. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.01.053 · Cited by 97 · see citing works
Mitochondria-targeted superoxide dismutase (SOD2) regulates radiation resistance and radiation stress response in HeLa cells
HOSOKI, A., YONEKURA, S.-I., ZHAO, Q.-L., WEI, Z.-L., TAKASAKI, I., TABUCHI, Y., WANG, L.-L., HASUIKE, S., NOMURA, T., TACHIBANA, A., et al. (2012) · Journal of Radiation Research · doi:10.1269/jrr.11034 · Cited by 97 · see citing works
Decreased transferrin and increased transferrin saturation in sera of women with preeclampsia: implications for oxidative stress
Hubel, Kozlov, Kagan, Evans, Davidge, McLaughlin, & Roberts (1996) · American Journal of Obstetrics and Gynecology · doi:10.1053/ob.1996.v175.a74252 · Cited by 91 · see citing works
Uronic acid-containing oligosaccharins: Their biosynthesis, degradation and signalling roles in non-diseased plant tissues
Dumville, J. C., & Fry, S. C. (2000) · Plant Physiology and Biochemistry · doi:10.1016/s0981-9428(00)00163-7 · Cited by 86 · see citing works
A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys
Kastman, E. K., Willette, A. A., Coe, C. L., Bendlin, B. B., Kosmatka, K. J., McLaren, D. G., Xu, G., Canu, E., Field, A. S., Alexander, A. L., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0835-10.2010 · Cited by 85 · see citing works
The mode of action of the antimalarial artemisinin and its derivatives
Kamchonwongpaisan, S., & Meshnick, S. R. (1996) · General Pharmacology: The Vascular System · doi:10.1016/0306-3623(95)02047-0 · Cited by 77 · see citing works
Reflections of an aging free radical
Halliwell, B. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.10.010 · Cited by 75 · see citing works
Self-citation
Hyperoxia retards growth and induces apoptosis, changes in vascular density and gene expression in transplanted gliomas in nude rats
Stuhr, L. E. B., Raa, A., Øyan, A. M., Kalland, K. H., Sakariassen, P. O., Petersen, K., Bjerkvig, R., & Reed, R. K. (2007) · Journal of Neuro-Oncology · doi:10.1007/s11060-007-9407-2 · Cited by 76 · see citing works
Antioxidative Activities of Kefir
Liu, J.-R., Lin, Y.-Y., Chen, M.-J., Chen, L.-J., & Lin, C.-W. (2005) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2005.567 · Cited by 72 · see citing works
A new murine oxidative stress model associated with senescence
Feng, R., He, W., & Ochi, H. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00232-9 · Cited by 72 · see citing works
Cytokine toxicity in insulin-producing cells is mediated by nitro-oxidative stress-induced hydroxyl radical formation in mitochondria
Gurgul-Convey, E., Mehmeti, I., Lortz, S., & Lenzen, S. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0747-1 · Cited by 70 · see citing works
Reactive oxygen species in the pathogenesis of sarcopenia
Xu, H., Brown, J. L., Bhaskaran, S., & Van Remmen, H. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.11.046 · Cited by 61 · see citing works
Apoptotic macrophage-derived foam cells of human atheromas are rich in iron and ferritin, suggesting iron-catalysed reactions to be involved in apoptosis
Yuan, X. M. (1999) · Free Radical Research · doi:10.1080/10715769900300241 · Cited by 59 · see citing works
Hematite Nanoparticles Larger than 90 nm Show No Sign of Toxicity in Terms of Lactate Dehydrogenase Release, Nitric Oxide Generation, Apoptosis, and Comet Assay in Murine Alveolar Macrophages and Human Lung Epithelial Cells
Freyria, F. S., Bonelli, B., Tomatis, M., Ghiazza, M., Gazzano, E., Ghigo, D., Garrone, E., & Fubini, B. (2012) · Chemical Research in Toxicology · doi:10.1021/tx2004294 · Cited by 57 · see citing works
The lipophilic metal chelators DP‐109 and DP‐460 are neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis
Petri, S., Calingasan, N. Y., Alsaied, O. A., Wille, E., Kiaei, M., Friedman, J. E., Baranova, O., Chavez, J. C., & Beal, M. F. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04604.x · Cited by 55 · see citing works
High-fat diet and alcohol intake promotes inflammation and impairs skin wound healing in Wistar rats
Rosa, D. F., Sarandy, M. M., Novaes, R. D., Freitas, M. B., do Carmo Gouveia Pelúzio, M., & Gonçalves, R. V. (2018) · Mediators of Inflammation · doi:10.1155/2018/4658583 · Cited by 55 · see citing works
Iron and peripheral arterial disease: revisiting the iron hypothesis in a different light
Ramakrishna, G., Rooke, T. W., & Cooper, L. T. (2003) · Vascular Medicine · doi:10.1191/1358863x03vm493ra · Cited by 54 · see citing works
Covalent Modification of DNA by Natural Products
Gates, K. S. (1999) · Comprehensive Natural Products Chemistry · doi:10.1016/b978-0-08-091283-7.00074-6 · Cited by 44 · see citing works
Role of iron in asbestos-body-induced oxidant Radical generation
Mario Governa, M. A. (1999) · Journal of Toxicology and Environmental Health, Part A · doi:10.1080/009841099157241 · Cited by 39 · see citing works
Modulation of DNA single-strand breaks by intracellular glutathione in human lung cells exposed to asbestos fibers
Puhakka, A., Ollikainen, T., Soini, Y., Kahlos, K., Säily, M., Koistinen, P., Pääkkö, P., Linnainmaa, K., & Kinnula, V. L. (2002) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(01)00322-9 · Cited by 40 · see citing works
Elevated serum bleomycin-detectable iron concentrations in patients with sepsis syndrome
Galley, H. F., & Webster, N. R. (1996) · Intensive Care Medicine · doi:10.1007/bf01712241 · Cited by 31 · see citing works
Unveiling ferroptosis as a promising therapeutic avenue for colorectal cancer and colitis treatment
Kao, A. T., Cabanlong, C. V., Padilla, K., & Xue, X. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.05.025 · Cited by 30 · see citing works
Erythrocyte‐aniune interaction leads to their accumulation and iron deposition in rat spleen
Khan, M. F., Kaphalia, B. S., & Ansari, G. A. S. (1995) · Journal of Toxicology and Environmental Health · doi:10.1080/15287399509531970 · Cited by 28 · see citing works

Authors: Halliwell, B., & Gutteridge, J. M. C.
ORCID: Halliwell, Barry
Venue: Methods in Enzymology
Publisher: Elsevier
Published: 1990
Volume: 186
Pages: 1-85
ISSN: 0076-6879 (ISSN-L)
DOI: 10.1016/0076-6879(90)86093-b
OpenAlex: W1734082729
Cited by: 4,994
References: 562
Citations by year: 2026: 16 · 2025: 47 · 2024: 52 · 2023: 78 · 2022: 101 · 2021: 96 · 2020: 95 · 2019: 96 · 2018: 103 · 2017: 129 · 2016: 122 · 2015: 142 · 2014: 184 · 2013: 196 · 2012: 214
FWCI: 53.61
Type: book chapter
Language: en
Open access: closed
Locations: Methods in enzymology on CD-ROM/Methods in enzymology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: free radicals, catalytic metal ions, transition metals, iron metabolism, copper metabolism, chelation therapy, lipid peroxidation, diene conjugation, thiobarbituric acid assay, oxidative damage, human disease, toxicology
MeSH terms: Disease, Free Radicals, Humans, Ions, Metals, Superoxides

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

[1] Role of free radicals and catalytic metal ions in human disease: An overview

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks