Reversibly Switching the Function of a Surface between Attacking and Defending against Bacteria
Abstract
Attack or defend! A smart polymer surface has two reversibly switchable equilibrium states, a cationic N,N-dimethyl-2-morpholinone (CB-Ring) and a zwitterionic carboxy betaine (CB-OH). CB-Ring will kill bacteria upon contact under dry conditions, whereas CB-OH will release the previously attached and dead bacteria and further resist adhesion of bacteria under wet conditions.
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The same authors developed a surface with morpholinone derivatives that can switch repeatedly between two equilibrium states for reversible kill and release.
“This is only a one-time transition between cationic and zwitterionic surface; therefore, in order to achieve a fully reversible “kill and release” functional surface, a surface with morpholinone derivatives that can be switched repeatedly between two equilibrium states was developed by the same authors.90”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [90]
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Cites
A Switchable Biocompatible Polymer Surface with Self‐Sterilizing and Nonfouling Capabilities
Cheng, G., Xue, H., Zhang, Z., Chen, S., & Jiang, S. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200803570 · Cited by 371 · see citing works
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Dual-function antibacterial surfaces for biomedical applications
Yu, Q., Wu, Z., & Chen, H. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.01.018 · Cited by 411 · see citing works
Wo, Y., Brisbois, E. J., Bartlett, R. H., & Meyerhoff, M. E. (2016) · Biomaterials Science · doi:10.1039/c6bm00271d · Cited by 251 · see citing works
Wang, B., Xu, Q., Ye, Z., Liu, H., Lin, Q., Nan, K., Li, Y., Wang, Y., Qi, L., & Chen, H. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b08893 · Cited by 130 · see citing works
Cao, B., Li, L., Wu, H., Tang, Q., Sun, B., Dong, H., Zhe, J., & Cheng, G. (2014) · Chem. Commun. · doi:10.1039/c3cc48878k · Cited by 66 · see citing works
Wang, B., Ye, Z., Xu, Q., Liu, H., Lin, Q., Chen, H., & Nan, K. (2016) · Biomaterials Science · doi:10.1039/c6bm00587j · Cited by 61 · see citing works
Retracted
- Authors
- Cao, Z., Mi, L., Mendiola, J., Ella‐Menye, J., Zhang, L., Xue, H., & Jiang, S.
- Affiliations
- University of Washington (US)
- Corresponding author
- Jiang, Shaoyi
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2011-12-30
- Volume
- 51
- Issue
- 11
- Pages
- 2602-2605
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2132391574
- Cited by
- 276
- References
- 1
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 15 · 2023: 11 · 2022: 23 · 2021: 21 · 2020: 22 · 2019: 27 · 2018: 24 · 2017: 29 · 2016: 28 · 2015: 28 · 2014: 18 · 2013: 12 · 2012: 2
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Keywords
- antibacterial surfaces, stimuli-responsive polymers, reversible switching, cationic polymers, zwitterionic polymers, bacterial adhesion, bacterial detachment
- MeSH terms
- Anti-Infective Agents, Bacteria, Betaine, Cations, Escherichia coli, Morpholines, Polymers, Surface Properties
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