Cited by 276Antimicrobial agents and applicationsPolymer Surface Interaction StudiesAdvanced Polymer Synthesis and Characterization

Reversibly Switching the Function of a Surface between Attacking and Defending against Bacteria

Cao, Zhiqiang, Mi, Luo, Mendiola, Jose, Ella‐Menye, Jean‐Rene, Zhang, Lei, Xue, Hong, Jiang, Shaoyi·2012·Angewandte Chemie International Edition

Abstract

Attack or defend! A smart polymer surface has two reversibly switchable equilibrium states, a cationic N,N-dimethyl-2-morpholinone (CB-Ring) and a zwitterionic carboxy betaine (CB-OH). CB-Ring will kill bacteria upon contact under dry conditions, whereas CB-OH will release the previously attached and dead bacteria and further resist adhesion of bacteria under wet conditions.

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Crossref · 10.1002/anie.201106466

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  • The same authors developed a surface with morpholinone derivatives that can switch repeatedly between two equilibrium states for reversible kill and release.

    “This is only a one-time transition between cationic and zwitterionic surface; therefore, in order to achieve a fully reversible “kill and release” functional surface, a surface with morpholinone derivatives that can be switched repeatedly between two equilibrium states was developed by the same authors.90”

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Authors
Cao, Z., Mi, L., Mendiola, J., Ella‐Menye, J., Zhang, L., Xue, H., & Jiang, S.
Affiliations
University of Washington (US)
Corresponding author
Jiang, Shaoyi
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2011-12-30
Volume
51
Issue
11
Pages
2602-2605
ISSN
  • 1433-7851 (ISSN-L)
  • 1521-3773
OpenAlex
W2132391574
Cited by
276
References
1
Citations by year
2026: 7 · 2025: 9 · 2024: 15 · 2023: 11 · 2022: 23 · 2021: 21 · 2020: 22 · 2019: 27 · 2018: 24 · 2017: 29 · 2016: 28 · 2015: 28 · 2014: 18 · 2013: 12 · 2012: 2
FWCI
4.82
Type
journal article
Language
en
Open access
closed
Locations
  • Angewandte Chemie International Edition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
Keywords
antibacterial surfaces, stimuli-responsive polymers, reversible switching, cationic polymers, zwitterionic polymers, bacterial adhesion, bacterial detachment
MeSH terms
Anti-Infective Agents, Bacteria, Betaine, Cations, Escherichia coli, Morpholines, Polymers, Surface Properties

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