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A “Renaissance” in Radical Trifluoromethylation
Abstract
This Minireview highlights recent developments in radical trifluoromethylation reactions. The trifluoromethyl group belongs to the privileged moieties in medicinal chemistry. Many drugs and drug candidates contain a trifluoromethyl substituent. Also in agrochemicals, the CF 3 moiety often appears. The present article addresses the radical trifluoromethylation of alkenes and arenes mainly focussing on recent achievements. However, important earlier work in this field is also covered.
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Cited by
Late-stage difluoromethylation: concepts, developments and perspective
Sap, J. B. I., Meyer, C. F., Straathof, N. J. W., Iwumene, N., am Ende, C. W., Trabanco, A. A., & Gouverneur, V. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00360g · Cited by 432
Electroorganic Synthesis under Flow Conditions
Elsherbini, M., & Wirth, T. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00497 · Cited by 303
Zhu, R., & Buchwald, S. L. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201307790 · Cited by 294
Metadata
- Authors
- Studer, A.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2012-08-13
- Volume
- 51
- Issue
- 36
- Pages
- 8950-8958
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2105361411
- Cited by
- 1,073
- References
- 0
- FWCI
- 61.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Studer, A. (2012). A “Renaissance” in Radical Trifluoromethylation. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201202624
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
