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A Continuum of Progress: Applications of N‐Hetereocyclic Carbene Catalysis in Total Synthesis
Open accessAbstract
N‐Heterocyclic carbene (NHC) catalyzed transformations have emerged as powerful tactics for the construction of complex molecules. Since Stetter’s report in 1975 of the total synthesis of cis‐jasmon and dihydrojasmon by using carbene catalysis, the use of NHCs in total synthesis has grown rapidly, particularly over the last decade. This renaissance is undoubtedly due to the recent developments in NHC‐catalyzed reactions, including new benzoin, Stetter, homoenolate, and aroylation processes. These transformations employ typical as well as Umpolung types of bond disconnections and have served as the key step in several new total syntheses. This Minireview highlights these reports and captures the excitement and emerging synthetic utility of carbene catalysis in total synthesis.
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Cited by
A Dual Lewis Base Activation Strategy for Enantioselective Carbene-Catalyzed Annulations
Izquierdo, J., Orue, A., & Scheidt, K. A. (2013) · Journal of the American Chemical Society · doi:10.1021/ja405833m · Cited by 332
Self-citationLiu, K., Schwenzer, M., & Studer, A. (2022) · ACS Catalysis · doi:10.1021/acscatal.2c03996 · Cited by 325
Shee, S., Mukherjee, S., Gonnade, R. G., & Biju, A. T. (2020) · Organic Letters · doi:10.1021/acs.orglett.0c01756 · Cited by 34
Metadata
- Authors
- Izquierdo, J., Hutson, G. E., Cohen, D. T., & Scheidt, K. A.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2012-10-16
- Volume
- 51
- Issue
- 47
- Pages
- 11686-11698
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2099873677
- Cited by
- 537
- References
- 0
- FWCI
- 25.66
- Type
- journal article
- Language
- en
- Open access
- green
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- Izquierdo, J., Hutson, G. E., Cohen, D. T., & Scheidt, K. A. (2012). A Continuum of Progress: Applications of N‐Hetereocyclic Carbene Catalysis in Total Synthesis. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201203704
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