The DOI matches its Crossref record; 139 of the 139 references it cites were found in a registry or an index.
Nonproteinogenic Amino Acid Building Blocks for Nonribosomal Peptide and Hybrid Polyketide Scaffolds
Open accessAbstract
Freestanding nonproteinogenic amino acids have long been recognized for their antimetabolite properties and tendency to be uncovered to reactive functionalities by the catalytic action of target enzymes. By installing them regiospecifically into biogenic peptides and proteins, it may be possible to usher a new era at the interface between small molecule and large molecule medicinal chemistry. Site‐selective protein functionalization offers uniquely attractive strategies for posttranslational modification of proteins. Last, but not least, many of the amino acids not selected by nature for protein incorporation offer rich architectural possibilities in the context of ribosomally derived polypeptides. This Review summarizes the biosynthetic routes to and metabolic logic for the major classes of the noncanonical amino acid building blocks that end up in both nonribosomal peptide frameworks and in hybrid nonribosomal peptide‐polyketide scaffolds.
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Cites
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The Biosynthetic Logic of Polyketide Diversity
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Biosynthesis of Nonribosomal Peptides
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Metadata
- Authors
- Walsh, C. T., O'Brien, R. V., & Khosla, C.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2013-05-31
- Volume
- 52
- Issue
- 28
- Pages
- 7098-7124
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2067489282
- Cited by
- 406
- References
- 139
- FWCI
- 13.90
- Type
- journal article
- Language
- en
- Open access
- green
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