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Cited by 261

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Asymmetric Synthesis of Spiropyrazolones through Phosphine‐Catalyzed [4+1] Annulation

Han, Xiaoyu, Yao, Weijun, Wang, Tianli, Tan, Yong Ren, Yan, Ziyu, Kwiatkowski, Jacek, Lu, Yixin·2014·Angewandte Chemie International Edition

Abstract

An enantioselective synthesis of spiropyrazolones from allenoate‐derived MBH acetates and pyrazolones through a phosphine‐mediated [4+1] annulation process has been developed. Spiropyrazolones were readily prepared in good chemical yields and good to high enantioselectivities. This is the first asymmetric example in which α‐substituted allenoates were utilized as a C 4 synthon for phosphine‐catalyzed [4+1] annulation.

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Metadata

Authors
Han, X., Yao, W., Wang, T., Tan, Y. R., Yan, Z., Kwiatkowski, J., & Lu, Y.
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2014-04-15
Volume
53
Issue
22
Pages
5643-5647
ISSN
  • 1433-7851 (ISSN-L)
  • 1521-3773
OpenAlex
W2075138214
Cited by
261
References
1
FWCI
17.49
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Asymmetric Synthesis of Spiropyrazolones through Phosphine‐Catalyzed [4+1] Annulation. https://app.cochat.ai/papers/10.1002/anie.201311214
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Han, X., Yao, W., Wang, T., Tan, Y. R., Yan, Z., Kwiatkowski, J., & Lu, Y. (2014). Asymmetric Synthesis of Spiropyrazolones through Phosphine‐Catalyzed [4+1] Annulation. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201311214

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