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DNA Nanoflowers for Multiplexed Cellular Imaging and Traceable Targeted Drug Delivery
Abstract
We present a facile approach to make aptamer‐conjugated FRET (fluorescent resonance energy transfer) nanoflowers (NFs) through rolling circle replication for multiplexed cellular imaging and traceable targeted drug delivery. The NFs can exhibit multi‐fluorescence emissions by a single‐wavelength excitation as a result of the DNA matrix covalently incorporated with three dye molecules able to perform FRET. Compared with the conventional DNA nanostructure assembly, NF assembly is independent of template sequences, avoiding the otherwise complicated design of DNA building blocks assembled into nanostructures by base‐pairing. The NFs were uniform and exhibited high fluorescence intensity and excellent photostability. Combined with the ability of traceable targeted drug delivery, these colorful DNA NFs provide a novel system for applications in multiplex fluorescent cellular imaging, effective screening of drugs, and therapeutic protocol development.
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Cited by
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Huang, X., Song, J., Yung, B. C., Huang, X., Xiong, Y., & Chen, X. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00612h · Cited by 820
Self‐assembled DNA nanoclews for the efficient delivery of CRISPR–Cas9 for genome editing
Sun, W., Ji, W., Hall, J. M., Hu, Q., Wang, C., Beisel, C. L., & Gu, Z. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201506030 · Cited by 629
Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications
Liu, C., Zhang, L., Liu, H., & Cheng, K. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.012 · Cited by 607
Aptamer-based targeted therapy
Zhu, G., & Chen, X. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.08.005 · Cited by 522
Self-citationCocoon-Like Self-Degradable DNA Nanoclew for Anticancer Drug Delivery
Sun, W., Jiang, T., Lu, Y., Reiff, M., Mo, R., & Gu, Z. (2014) · Journal of the American Chemical Society · doi:10.1021/ja5088024 · Cited by 329
Metadata
- Authors
- Hu, R., Zhang, X., Zhao, Z., Zhu, G., Chen, T., Fu, T., & Tan, W.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2014-04-17
- Volume
- 53
- Issue
- 23
- Pages
- 5821-5826
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2036226488
- Cited by
- 337
- References
- 0
- FWCI
- 10.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hu, R., Zhang, X., Zhao, Z., Zhu, G., Chen, T., Fu, T., & Tan, W. (2014). DNA Nanoflowers for Multiplexed Cellular Imaging and Traceable Targeted Drug Delivery. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201400323
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