ROS/RNS and Base Dual Activatable Merocyanine‐Based NIR‐II Fluorescent Molecular Probe for in vivo Biosensing
Abstract
Inflammation usually results in high‐level reactive oxygen species (ROS) and reactive nitrogen species (RNS) not only in acidic tissue but also in alkaline tissue. However, noninvasively in vivo monitoring reactive species specifically within alkaline tissue remains a huge challenge. Here we introduce a dual activatable fluorescent probe PN910 located in the second near‐infrared window (NIR‐II, 900–1700 nm), which shows high selectivity toward H 2 O 2 and OONO − at pH beyond 7.4. Then we verified that PN910 could be used for the real‐time, specific and accurate monitoring of cystitis and colitis for living animals. This report presents a unique approach to the development of dual activatable probe for in vivo biosensing.
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Xanthene dyes, particularly rhodamines and fluoresceins, have attracted considerable attention in biomedical imaging owing to outstanding photophysical properties including high molar absorptivity, excellent photostability, facile functionalization, and tunable emission.
“Xanthene dyes, particularly rhodamines and fluoresceins, have attracted considerable attention in biomedical imaging owing to their outstanding photophysical properties, including high molar absorptivity, excellent photostability, facile functionalization, and tunable emission”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [172]
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References 50 · Cited by 176
- Authors
- Zhang, X., Chen, Y., He, H., Wang, S., Lei, Z., & Zhang, F.
- Affiliations
- Fudan University (CN)
- Key Laboratory of Smart Drug Delivery, Ministry of Education (CN)
- Corresponding author
- Lei, Zuhai
- Zhang, Fan
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2021-11-08
- Volume
- 60
- Issue
- 50
- Pages
- 26337-26341
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3202247968
- Cited by
- 176
- References
- 50
- Citations by year
- 2026: 31 · 2025: 32 · 2024: 30 · 2023: 29 · 2022: 54
- FWCI
- 10.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology of the People's Republic of China (2017YFA0207303)
- National Natural Science Foundation of China (22088101, 21725502, 51961145403, 21904023, 21908030)
- Science and Technology Commission of Shanghai Municipality (20JC1411700, 19490713100, 20490710600, 20S31903700)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Keywords
- reactive oxygen species, reactive nitrogen species, merocyanine, hydrogen peroxide detection, peroxynitrite detection, in vivo biosensing, cystitis, colitis, inflammation imaging
- MeSH terms
- Animals, Benzopyrans, Colitis, Cystitis, Fluorescent Dyes, Hydrogen Peroxide, Indoles, Infrared Rays, Nitrates, Biosensing Techniques, Molecular Structure, Reactive Oxygen Species, Reactive Nitrogen Species, Mice
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