Small‐Molecule‐Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging

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Items 101–200 of 216

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  19. Chimera induced protein degradation: PROTACs and beyond
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  27. Targeted Protein Degradation
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  44. Selective degradation of the estrogen receptor in the treatment of cancers
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  49. Targeted Protein Degradation: Principles, Strategies, and Applications
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  75. Advances in AR-Targeting Chimeras: A Case Study of proteolysis-targeting Chimeras From Bench to Bedside
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  76. Androgen Receptor Ligands: Agonists and Antagonists
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  85. Idegenerering i IT-bedrifter - åpenhet og nettverks betydning for idégenerering
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  87. Androgen receptor degraders as antiprostate cancer agents
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  88. Androgen Receptor Ligands: Agonists and Antagonists
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  89. Protease-mediated degradation
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  91. Design, synthesis, and biological evaluation of hydrophobic-tagged poly (ADP-ribose) polymerase 1 (PARP1) degraders
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  98. Hydrophobic Tag Protein Degraders: An Emerging Therapeutic Strategy for Cancer
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  99. BindingDB Entry 50016950: Therapeutic Strategies to Target the Androgen Receptor.
    BindingDB · 2023 · UC San Diego
  100. BindingDB Entry 50012748: A critical update on the strategies towards modulators targeting androgen receptors.
    BindingDB · 2022 · UC San Diego