The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
X‐ray Radiation‐Controlled NO‐Release for On‐Demand Depth‐Independent Hypoxic Radiosensitization
Abstract
Multifunctional stimuli‐responsive nanotheranostic systems are highly desirable for realizing simultaneous biomedical imaging and on‐demand therapy with minimized adverse effects. Herein, we present the construction of an intelligent X‐ray‐controlled NO‐releasing upconversion nanotheranostic system (termed as PEG‐USMSs‐SNO) by engineering UCNPs with S‐nitrosothiol (R‐SNO)‐grafted mesoporous silica. The PEG‐USMSs‐SNO is designed to respond sensitively to X‐ray radiation for breaking down the SN bond of SNO to release NO, which leads to X‐ray dose‐controlled NO release for on‐demand hypoxic radiosensitization besides upconversion luminescent imaging through UCNPs in vitro and in vivo. Thanks to the high live‐body permeability of X‐ray, our developed PEG‐USMSs‐SNO may provide a new technique for achieving depth‐independent controlled NO release and positioned radiotherapy enhancement against deep‐seated solid tumors.
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Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics
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In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers
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Self-citationQuantum dots and nanoparticles for photodynamic and radiation therapies of cancer
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Self-citationStimuli-Responsive Nanomaterials for Biomedical Applications
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Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy
Song, G., Cheng, L., Chao, Y., Yang, K., & Liu, Z. (2017) · Advanced Materials · doi:10.1002/adma.201700996 · Cited by 771
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X-ray-activated nanosystems for theranostic applications
Chen, X., Song, J., Chen, X., & Yang, H. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00921j · Cited by 401
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Metadata
- Authors
- Fan, W., Bu, W., Zhang, Z., Shen, B., Zhang, H., He, Q., Ni, D., Cui, Z., Zhao, K., Bu, J., Du, J., Liu, J., & Shi, J.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2015-07-23
- Volume
- 54
- Issue
- 47
- Pages
- 14026-14030
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2132904123
- Cited by
- 286
- References
- 33
- FWCI
- 9.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fan, W., Bu, W., Zhang, Z., Shen, B., Zhang, H., He, Q., Ni, D., Cui, Z., Zhao, K., Bu, J., Du, J., Liu, J., & Shi, J. (2015). X‐ray Radiation‐Controlled NO‐Release for On‐Demand Depth‐Independent Hypoxic Radiosensitization. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201504536
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