The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy
Abstract
Radiation therapy (RT) including external beam radiotherapy (EBRT) and internal radioisotope therapy (RIT) has been widely used for clinical cancer treatment. However, owing to the low radiation absorption of tumors, high doses of ionizing radiations are often needed during RT, leading to severe damages to normal tissues adjacent to tumors. Meanwhile, the RT efficacies are limited by different mechanisms, among which the tumor hypoxia‐associated radiation resistance is a well‐known one, as there exists hypoxia inside most solid tumors while oxygen is essential to enhance radiation‐induced DNA damages. With the development in nanotechnology, there have been great interests in using nanomedicine strategies to enhance radiation responses of tumors. Nanomaterials containing high‐Z elements to absorb radiation rays (e.g. X‐ray) can act as radio‐sensitizers to deposit radiation energy within tumors and promote treatment efficacy. Nanoscale carriers are able to deliver therapeutic radioisotopes into tumors for internal RIT, or chemotherapeutic drugs for synergistically combined chemo‐radiotherapy. As uncovered in recent studies, the tumor microenvironment could be modulated by various nanomedicine approaches to overcome hypoxia‐associated radiation resistance. Herein, the authors will summarize the applications of nanomedicine for RT cancer treatment, and pay particular attention to the latest development of ‘advanced materials' for enhanced cancer RT.
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Gold Nanoparticles as Radiosensitizers in Cancer Radiotherapy
Chen, Y., Yang, J., Fu, S., & Wu, J. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s272902 · Cited by 319
Functional Immune Cell‐Derived Exosomes Engineered for the Trilogy of Radiotherapy Sensitization
Ma, X., Yao, M., Gao, Y., Yue, Y., Li, Y., Zhang, T., Nie, G., Zhao, X., & Liang, X. (2022) · Advanced Science · doi:10.1002/advs.202106031 · Cited by 82
Au-Pt Nanoparticle Formulation as a Radiosensitizer for Radiotherapy with Dual Effects
Yang, S., Han, G., Chen, Q., Yu, L., Wang, P., Zhang, Q., Dong, J., Zhang, W., & Huang, J. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s287523 · Cited by 81
Metadata
- Authors
- Song, G., Cheng, L., Chao, Y., Yang, K., & Liu, Z.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2017-06-23
- Volume
- 29
- Issue
- 32
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2632077510
- Cited by
- 771
- References
- 9
- FWCI
- 40.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Song, G., Cheng, L., Chao, Y., Yang, K., & Liu, Z. (2017). Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy. Advanced Materials. https://doi.org/10.1002/adma.201700996
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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