The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Facile Generation of Tumor‐pH‐Labile Linkage‐Bridged Block Copolymers for Chemotherapeutic Delivery
Abstract
Successful bench‐to‐bedside translation of nanomedicine relies heavily on the development of nanocarriers with superior therapeutic efficacy and high biocompatibility. However, the optimal strategy for improving one aspect often conflicts with the other. Herein, we report a tactic of designing tumor‐pH‐labile linkage‐bridged copolymers of clinically validated poly(d,l‐lactide) and poly(ethylene glycol) (PEG‐Dlink m‐PDLLA) for safe and effective drug delivery. Upon arriving at the tumor site, PEG‐Dlink m‐PDLLA nanoparticles will lose the PEG layer and increase zeta potential by responding to tumor acidity, which significantly enhances cellular uptake and improves the in vivo tumor inhibition rate to 78.1 % in comparison to 47.8 % of the non‐responsive control. Furthermore, PEG‐Dlink m‐PDLLA nanoparticles show comparable biocompatibility with the clinically used PEG‐b‐PDLLA micelle. The improved therapeutic efficacy and safety demonstrate great promise for our strategy in future translational studies.
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Cites
Principles of nanoparticle design for overcoming biological barriers to drug delivery
Blanco, E., Shen, H., & Ferrari, M. (2015) · Nature Biotechnology · doi:10.1038/nbt.3330 · Cited by 7,002
Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
Knop, K., Hoogenboom, R., Fischer, D., & Schubert, U. S. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200902672 · Cited by 3,533
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
Progress of drug-loaded polymeric micelles into clinical studies
Cabral, H., & Kataoka, K. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.042 · Cited by 837
The role of micelle size in tumor accumulation, penetration, and treatment
Wang, J., Mao, W., Lock, L. L., Tang, J., Sui, M., Sun, W., Cui, H., Xu, D., & Shen, Y. (2015) · ACS Nano · doi:10.1021/acsnano.5b02017 · Cited by 635
Self-citationZhang, Q., Re Ko, N., & Kwon Oh, J. (2012) · Chemical Communications · doi:10.1039/c2cc32408c · Cited by 395
Cited by
Dai, Y., Xu, C., Sun, X., & Chen, X. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00592f · Cited by 931
Self-citationMolecular Motion in Aggregates: Manipulating TICT for Boosting Photothermal Theranostics
Liu, S., Zhou, X., Zhang, H., Ou, H., Lam, J. W. Y., Liu, Y., Shi, L., Ding, D., & Tang, B. Z. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b13889 · Cited by 647
Self-citationTannic acid: a crosslinker leading to versatile functional polymeric networks: a review
Chen, C., Yang, H., Yang, X., & Ma, Q. (2022) · RSC Advances · doi:10.1039/d1ra07657d · Cited by 561
The acidic tumor microenvironment: a target for smart cancer nano-theranostics
Feng, L., Dong, Z., Tao, D., Zhang, Y., & Liu, Z. (2018) · National Science Review · doi:10.1093/nsr/nwx062 · Cited by 426
Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery
Fang, Y., Xue, J., Gao, S., Lu, A., Yang, D., Jiang, H., He, Y., & Shi, K. (2017) · Drug Delivery · doi:10.1080/10717544.2017.1388451 · Cited by 386
Metadata
- Authors
- Sun, C., Liu, Y., Du, J., Cao, Z., Xu, C., & Wang, J.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2015-12-03
- Volume
- 55
- Issue
- 3
- Pages
- 1010-1014
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2181565536
- Cited by
- 165
- References
- 6
- FWCI
- 7.54
- Type
- journal article
- Language
- en
- Open access
- closed
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