Molecular Motion in Aggregates: Manipulating TICT for Boosting Photothermal Theranostics
Abstract
Planar donor and acceptor (D-A) conjugated structures are generally believed to be the standard for architecting highly efficient photothermal theranostic agents, in order to restrict intramolecular motions in aggregates (nanoparticles). However, other channels of extra nonradiative decay may be blocked. Now this challenge is addressed by proposing an "abnormal" strategy based on molecular motion in aggregates. Molecular rotors and bulky alkyl chains are grafted to the central D-A core to lower intermolecular interaction. The enhanced molecular motion favors the formation of a dark twisted intramolecular charge transfer state, whose nonradiative decay enhances the photothermal properties. Result shows that small-molecule NIRb14 with long alkyl chains branched at the second carbon exhibits enhanced photothermal properties compared with NIRb6, with short branched chains, and much higher than NIR6, with short linear chains, and the commercial gold nanorods. Both in vitro and in vivo experiments demonstrate that NIRb14 nanoparticles can be used as nanoagents for photoacoustic imaging-guided photothermal therapy. Moreover, charge reversal poly(β-amino ester) makes NIRb14 specifically accumulate at tumor sites. This study thus provides an excited molecular motion approach toward efficient phototheranostic agents.
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- Authors
- Liu, S., Zhou, X., Zhang, H., Ou, H., Lam, J. W. Y., Liu, Y., Shi, L., Ding, D., & Tang, B. Z.
- Affiliations
- Hong Kong University of Science and Technology (HK)
- Shanxi Medical University (CN)
- Nankai University (CN)
- Corresponding author
- Shi, Linqi
- Ding, Dan
- Tang, Ben Zhong
- ORCID
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-03-13
- Volume
- 141
- Issue
- 13
- Pages
- 5359-5368
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2922175718
- Cited by
- 647
- References
- 70
- Citations by year
- 2026: 45 · 2025: 65 · 2024: 83 · 2023: 91 · 2022: 109 · 2021: 120 · 2020: 97 · 2019: 37
- FWCI
- 31.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of the American Chemical Society (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- National Natural Science Foundation of China (21788102, 21490570, 51622305, 21490574, 51873092)
- Innovation and Technology Commission (ITCPD/17-9, ITC-CNERC14SC01, ITS/254/17)
- Research Grants Council, University Grants Committee (C6009-17G, C2014-15G, A-HKUST605/16, N-HKUST604/14, 16308016, 16308116)
- Ministry of Science and Technology of the People's Republic of China (2015CB856503, 2018YFE0190200)
- Shenzhen Municipality (JCY20170818113602462, JCYJ20160229205601482)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Photochemistry and Electron Transfer Studies
- Keywords
- twisted intramolecular charge transfer, donor-acceptor conjugates, alkyl chain grafting, molecular rotors, nonradiative decay, gold nanoparticles, poly(β-amino ester), tumor targeting, intramolecular interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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