Cited by 647Nanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsPhotochemistry and Electron Transfer Studies

Molecular Motion in Aggregates: Manipulating TICT for Boosting Photothermal Theranostics

Liu, Shunjie, Zhou, Xin, Zhang, Haoke, Ou, Hanlin, Lam, Jacky W. Y., Liu, Yang, Shi, Linqi, Ding, Dan +1 more·2019·Journal of the American Chemical Society

Abstract

Planar donor and acceptor (D-A) conjugated structures are generally believed to be the standard for architecting highly efficient photothermal theranostic agents, in order to restrict intramolecular motions in aggregates (nanoparticles). However, other channels of extra nonradiative decay may be blocked. Now this challenge is addressed by proposing an "abnormal" strategy based on molecular motion in aggregates. Molecular rotors and bulky alkyl chains are grafted to the central D-A core to lower intermolecular interaction. The enhanced molecular motion favors the formation of a dark twisted intramolecular charge transfer state, whose nonradiative decay enhances the photothermal properties. Result shows that small-molecule NIRb14 with long alkyl chains branched at the second carbon exhibits enhanced photothermal properties compared with NIRb6, with short branched chains, and much higher than NIR6, with short linear chains, and the commercial gold nanorods. Both in vitro and in vivo experiments demonstrate that NIRb14 nanoparticles can be used as nanoagents for photoacoustic imaging-guided photothermal therapy. Moreover, charge reversal poly(β-amino ester) makes NIRb14 specifically accumulate at tumor sites. This study thus provides an excited molecular motion approach toward efficient phototheranostic agents.

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Crossref · 10.1021/jacs.8b13889

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Authors
Liu, S., Zhou, X., Zhang, H., Ou, H., Lam, J. W. Y., Liu, Y., Shi, L., Ding, D., & Tang, B. Z.
Affiliations
  • Hong Kong University of Science and Technology (HK)
  • Shanxi Medical University (CN)
  • Nankai University (CN)
Corresponding author
  • Shi, Linqi
  • Ding, Dan
  • Tang, Ben Zhong
Venue
Journal of the American Chemical Society
Published
2019-03-13
Volume
141
Issue
13
Pages
5359-5368
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
OpenAlex
W2922175718
Cited by
647
References
70
Citations by year
2026: 45 · 2025: 65 · 2024: 83 · 2023: 91 · 2022: 109 · 2021: 120 · 2020: 97 · 2019: 37
FWCI
31.99
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of the American Chemical Society (publishedVersion)
  • PubMed (publishedVersion)
  • Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
Funders
  • National Natural Science Foundation of China (21788102, 21490570, 51622305, 21490574, 51873092)
  • Innovation and Technology Commission (ITCPD/17-9, ITC-CNERC14SC01, ITS/254/17)
  • Research Grants Council, University Grants Committee (C6009-17G, C2014-15G, A-HKUST605/16, N-HKUST604/14, 16308016, 16308116)
  • Ministry of Science and Technology of the People's Republic of China (2015CB856503, 2018YFE0190200)
  • Shenzhen Municipality (JCY20170818113602462, JCYJ20160229205601482)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
  • Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Photochemistry and Electron Transfer Studies
Keywords
twisted intramolecular charge transfer, donor-acceptor conjugates, alkyl chain grafting, molecular rotors, nonradiative decay, gold nanoparticles, poly(β-amino ester), tumor targeting, intramolecular interactions

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