The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
A Smart Photosensitizer–Manganese Dioxide Nanosystem for Enhanced Photodynamic Therapy by Reducing Glutathione Levels in Cancer Cells
Open accessAbstract
Photodynamic therapy (PDT) has been applied in cancer treatment by utilizing reactive oxygen species to kill cancer cells. However, a high concentration of glutathione (GSH) is present in cancer cells and can consume reactive oxygen species. To address this problem, we report the development of a photosensitizer–MnO 2 nanosystem for highly efficient PDT. In our design, MnO 2 nanosheets adsorb photosensitizer chlorin e6 (Ce6), protect it from self‐destruction upon light irradiation, and efficiently deliver it into cells. The nanosystem also inhibits extracellular singlet oxygen generation by Ce6, leading to fewer side effects. Once endocytosed, the MnO 2 nanosheets are reduced by intracellular GSH. As a result, the nanosystem is disintegrated, simultaneously releasing Ce6 and decreasing the level of GSH for highly efficient PDT. Moreover, fluorescence recovery, accompanied by the dissolution of MnO 2 nanosheets, can provide a fluorescence signal for monitoring the efficacy of delivery.
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Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies
Xie, J., Wang, Y., Choi, W., Jangili, P., Ge, Y., Xu, Y., Kang, J., Liu, L., Zhang, B., Xie, Z., et al. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01370f · Cited by 522
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Metadata
- Authors
- Fan, H., Yan, G., Zhao, Z., Hu, X., Zhang, W., Liu, H., Fu, X., Fu, T., Zhang, X., & Tan, W.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2016-03-24
- Volume
- 55
- Issue
- 18
- Pages
- 5477-5482
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2305745682
- Cited by
- 567
- References
- 36
- FWCI
- 30.09
- Type
- journal article
- Language
- en
- Open access
- green
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- Fan, H., Yan, G., Zhao, Z., Hu, X., Zhang, W., Liu, H., Fu, X., Fu, T., Zhang, X., & Tan, W. (2016). A Smart Photosensitizer–Manganese Dioxide Nanosystem for Enhanced Photodynamic Therapy by Reducing Glutathione Levels in Cancer Cells. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201510748
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