Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691 · see citing works

ROS function in redox signaling and oxidative stress

Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931 · see citing works

Oxidative stress: oxidants and antioxidants

Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577 · see citing works

Thiol–Ene Click Chemistry

Hoyle, C. E., & Bowman, C. N. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200903924 · Cited by 4,201 · see citing works

Glutathione Metabolism and Its Implications for Health

Wu, G., Lupton, J. R., Turner, N. D., Fang, Y.-Z., & Yang, S. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.3.489 · Cited by 3,842 · see citing works

Association of reactive oxygen species levels and radioresistance in cancer stem cells

Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555 · see citing works

Functional Nanomaterials for Phototherapies of Cancer

Cheng, L., Wang, C., Feng, L., Yang, K., & Liu, Z. (2014) · Chemical Reviews · doi:10.1021/cr400532z · Cited by 2,432 · see citing works

Glutathione synthesis

Lu, S. C.-L. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.09.008 · Cited by 2,192 · see citing works

Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species

He, L., He, T., Farrar, S., Ji, L., Liu, T., & Ma, X. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485089 · Cited by 2,142 · see citing works

Regulation of glutathione synthesis

Lu, S. C.-L. (2008) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2008.05.005 · Cited by 2,131 · see citing works

Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

Dixon, S. J., Patel, D. N., Welsch, M., Skouta, R., Lee, E. D., Hayano, M., Thomas, A. G., Gleason, C. E., Tatonetti, N. P., Slusher, B. S., et al. (2014) · eLife · doi:10.7554/elife.02523 · Cited by 2,088 · see citing works

Ferroptosis, a new form of cell death: opportunities and challenges in cancer

Mou, Y., Wang, J., Wu, J., He, D., Zhang, C., Duan, C., & Li, B. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0720-y · Cited by 1,943 · see citing works

Unique Cellular Interaction of Silver Nanoparticles: Size-Dependent Generation of Reactive Oxygen Species

Carlson, C., Hussain, S. M., Schrand, A. M., Braydich‐Stolle, L. K., Hess, K. L., Jones, R. L., & Schlager, J. J. (2008) · The Journal of Physical Chemistry B · doi:10.1021/jp712087m · Cited by 1,808 · see citing works

Simultaneous Fenton‐like Ion Delivery and Glutathione Depletion by MnO 2 ‐Based Nanoagent to Enhance Chemodynamic Therapy

Lin, L., Song, J., Song, L., Ke, K., Liu, Y., Zhou, Z., Shen, Z., Li, J., Yáng, Z., Tang, W., et al. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201712027 · Cited by 1,472 · see citing works

Terminology of metal–organic frameworks and coordination polymers (IUPAC Recommendations 2013)

Batten, S. R., Champness, N. R., Chen, X., García‐Martínez, J., Kitagawa, S., Öhrström, L. R., O’Keeffe, M., Suh, M. P., & Reedijk, J. (2013) · Pure and Applied Chemistry · doi:10.1351/pac-rec-12-11-20 · Cited by 1,346 · see citing works

Cysteine depletion induces pancreatic tumor ferroptosis in mice

Badgley, M. A., Kremer, D. M., Maurer, H. C., DelGiorno, K. E., Lee, H.-J., Purohit, V., Sagalovskiy, I. R., Ma, A., Kapilian, J., Firl, C. E. M., et al. (2020) · Science · doi:10.1126/science.aaw9872 · Cited by 1,294 · see citing works

Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions

Lushchak, V. I. (2012) · Journal of Amino Acids · doi:10.1155/2012/736837 · Cited by 1,266 · see citing works

Glutathione metabolism in cancer progression and treatment resistance

Bansal, A., & Simon, M. C. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201804161 · Cited by 1,234 · see citing works

Self-Assembled Copper–Amino Acid Nanoparticles for in Situ Glutathione “AND” H2O2 Sequentially Triggered Chemodynamic Therapy

Ma, B., Wang, S., Liu, F., Zhang, S., Duan, J., Li, Z., Kong, Y., Sang, Y., Liu, H., Bu, W., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b08714 · Cited by 1,228 · see citing works

Role of Glutathione in Cancer Progression and Chemoresistance

Traverso, N., Ricciarelli, R., Nitti, M., Marengo, B., Furfaro, A. L., Pronzato, M. A., Marinari, U. M., & Domenicotti, C. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/972913 · Cited by 1,208 · see citing works

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

Wu, J., Minikes, A. M., Gao, M., Bian, H., Li, Y., Stockwell, B. R., Chen, Z.-N., & Jiang, X. (2019) · Nature · doi:10.1038/s41586-019-1426-6 · Cited by 1,110 · see citing works

The Cystine/Glutamate Antiporter System x c − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

Lewerenz, J., Hewett, S. J., Huang, Y. S., Lambros, M. P., Gout, P. W., Kalivas, P. W., Massie, A., Smolders, I. J., Methner, A., Pergande, M., et al. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4391 · Cited by 996 · see citing works

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

Harris, I. S., Treloar, A. E., Inoue, S., Sasaki, M., Gorrini, C., Lee, K. C., Yung, K. Y., Brenner, D., Knobbe-Thomsen, C. B., Cox, M. A., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.11.019 · Cited by 993 · see citing works

Oxidative Stress: Introductory Remarks

Sies, H. (1985) · Elsevier eBooks · doi:10.1016/b978-0-12-642760-8.50005-3 · Cited by 989 · see citing works

High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.

Godwin, A. K., Meister, A., O'Dwyer, P. J., Huang, C. S., Hamilton, T. C., & Anderson, M. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.3070 · Cited by 926 · see citing works

Reactive oxygen species and cancer paradox: To promote or to suppress?

Galadari, S., Rahman, A. U., Pallichankandy, S., & Thayyullathil, F. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.004 · Cited by 895 · see citing works

Oncologic photodynamic therapy photosensitizers: A clinical review

Allison, R. R., & Sibata, C. H. (2010) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2010.02.001 · Cited by 840 · see citing works

Cellular responses induced by silver nanoparticles: In vitro studies

Arora, S., Jain, J., Rajwade, J. M., & Paknikar, K. M. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2008.04.009 · Cited by 736 · see citing works

Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model

Zhang, Y., Tan, H., Daniels, J. D., Zandkarimi, F., Liu, H., Brown, L. M., Uchida, K., O’Connor, O. A., & Stockwell, B. R. (2019) · Cell chemical biology · doi:10.1016/j.chembiol.2019.01.008 · Cited by 729 · see citing works

Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis

Piao, M. J., Kang, K. A., Lee, I. K., Kim, H. S., Kim, S., Choi, J. Y., Choi, J., & Hyun, J. W. (2010) · Toxicology Letters · doi:10.1016/j.toxlet.2010.12.010 · Cited by 702 · see citing works

Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine

Zhang, J., Pavlova, N. N., & Thompson, C. B. (2017) · The EMBO Journal · doi:10.15252/embj.201696151 · Cited by 651 · see citing works

Biodegradable Biomimic Copper/Manganese Silicate Nanospheres for Chemodynamic/Photodynamic Synergistic Therapy with Simultaneous Glutathione Depletion and Hypoxia Relief

Liu, C., Wang, D., Zhang, S., Cheng, Y., Yang, F., Xing, Y., Xu, T., Dong, H., & Zhang, X. (2019) · ACS Nano · doi:10.1021/acsnano.8b09387 · Cited by 642 · see citing works

The Complex Interplay between Antioxidants and ROS in Cancer

Harris, I. S., & DeNicola, G. M. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.03.002 · Cited by 638 · see citing works

Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases

Allocati, N., Masulli, M., Di Ilio, C., & Federici, L. (2018) · Oncogenesis · doi:10.1038/s41389-017-0025-3 · Cited by 625 · see citing works

All-in-One Theranostic Nanoagent with Enhanced Reactive Oxygen Species Generation and Modulating Tumor Microenvironment Ability for Effective Tumor Eradication

Liu, Y., Zhen, W., Jin, L., Zhang, S., Sun, G., Zhang, T., Xu, X., Song, S., Wang, Y., Liu, J., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b01893 · Cited by 618 · see citing works

Glutathione levels in human tumors

Gamcsik, M. P., Kasibhatla, M. S., Teeter, S. D., & Colvin, O. M. (2012) · Biomarkers · doi:10.3109/1354750x.2012.715672 · Cited by 608 · see citing works

Bioinspired Construction of a Nanozyme-Based H2O2 Homeostasis Disruptor for Intensive Chemodynamic Therapy

Sang, Y., Cao, F., Li, W., Zhang, L., You, Y., Deng, Q., Dong, K., Ren, J., & Qu, X. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.9b12873 · Cited by 596 · see citing works

GSH‐Depleted Nanozymes with Hyperthermia‐Enhanced Dual Enzyme‐Mimic Activities for Tumor Nanocatalytic Therapy

Dong, S., Dong, Y., Jia, T., Liu, S., Liu, J., Yang, D., He, F., Gai, S., Yang, P., & Lin, J. (2020) · Advanced Materials · doi:10.1002/adma.202002439 · Cited by 592 · see citing works

A Smart Photosensitizer–Manganese Dioxide Nanosystem for Enhanced Photodynamic Therapy by Reducing Glutathione Levels in Cancer Cells

Fan, H., Yan, G., Zhao, Z., Hu, X., Zhang, W., Liu, H., Fu, X., Fu, T., Zhang, X., & Tan, W. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201510748 · Cited by 567 · see citing works

Respiratory chain linked H₂O₂ production in pigeon heart mitochondria

Loschen, G., & Flohé, L. (1971) · FEBS Letters · doi:10.1016/0014-5793(71)80459-3 · Cited by 552 · see citing works

An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy

Liu, C., Cao, Y., Cheng, Y., Wang, D., Xu, T., Su, L., Zhang, X., & Dong, H. (2020) · Nature Communications · doi:10.1038/s41467-020-15591-4 · Cited by 545 · see citing works

GSH‐Depleted PtCu 3 Nanocages for Chemodynamic‐ Enhanced Sonodynamic Cancer Therapy

Zhong, X., Wang, X., Cheng, L., Tang, Y., Zhan, G., Gong, F., Zhang, R., Hu, J., Liu, Z., & Yang, X. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201907954 · Cited by 541 · see citing works

Ultrasmall Oxygen‐Deficient Bimetallic Oxide MnWO X Nanoparticles for Depletion of Endogenous GSH and Enhanced Sonodynamic Cancer Therapy

Gong, F., Cheng, L., Yang, N., Betzer, O., Feng, L., Zhou, L., Li, Y., Chen, R., Popovtzer, R., & Liu, Z. (2019) · Advanced Materials · doi:10.1002/adma.201900730 · Cited by 534 · see citing works

The γ-Glutamyl Cycle: A Possible Transport System for Amino Acids

Orłowski, M., & Meister, A. (1970) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.67.3.1248 · Cited by 531 · see citing works

N-Acetylcysteine (NAC): Impacts on Human Health

Tenório, M. C. D. S., Graciliano, N. G., Moura, F. A., Oliveira, A. C. M. D., & Goulart, M. O. F. (2021) · Antioxidants · doi:10.3390/antiox10060967 · Cited by 526 · see citing works

Copper(II)–Graphitic Carbon Nitride Triggered Synergy: Improved ROS Generation and Reduced Glutathione Levels for Enhanced Photodynamic Therapy

Ju, E., Dong, K., Chen, Z., Liu, Z., Liu, C., Huang, Y., Wang, Z., Pu, F., Ren, J., & Qu, X. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201605509 · Cited by 508 · see citing works

Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line

Armstrong, J. S., Steinauer, K. K., Hornung, B., Irish, J. M., Lecane, P. S., Birrell, G. W., Peehl, D. M., & Knox, S. J. (2002) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400959 · Cited by 507 · see citing works

Surface Charge Switchable Supramolecular Nanocarriers for Nitric Oxide Synergistic Photodynamic Eradication of Biofilms

Hu, D., Deng, Y., Jia, F., Jin, Q., & Ji, J. (2019) · ACS Nano · doi:10.1021/acsnano.9b05493 · Cited by 490 · see citing works

Advances in redox-responsive drug delivery systems of tumor microenvironment

Guo, X., Cheng, Y., Zhao, X., Luo, Y., Chen, J., & Yuan, W.-E. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0398-2 · Cited by 459 · see citing works

Amplification of Tumor Oxidative Stresses with Liposomal Fenton Catalyst and Glutathione Inhibitor for Enhanced Cancer Chemotherapy and Radiotherapy

Dong, Z., Feng, L., Chao, Y., Hao, Y., Chen, M., Gong, F., Han, X., Zhang, R., Cheng, L., & Liu, Z. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b03905 · Cited by 437 · see citing works

ABC transporters as mediators of drug resistance and contributors to cancer cell biology

Fletcher, J. I., Williams, R. T., Henderson, M. J., Norris, M. D., & Haber, M. (2016) · Drug Resistance Updates · doi:10.1016/j.drup.2016.03.001 · Cited by 423 · see citing works

Specific Generation of Singlet Oxygen through the Russell Mechanism in Hypoxic Tumors and GSH Depletion by Cu‐TCPP Nanosheets for Cancer Therapy

Wang, C., Cao, F., Ruan, Y., Jia, X., Zhen, W., & Jiang, X. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201903981 · Cited by 411 · see citing works

The ferroptosis inducer erastin irreversibly inhibits system xc− and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells

Sato, M., Kusumi, R., Hamashima, S., Kobayashi, S., Sasaki, S., Komiyama, Y., Izumikawa, T., Conrad, M., Bannai, S., & Sato, H. (2018) · Scientific Reports · doi:10.1038/s41598-018-19213-4 · Cited by 409 · see citing works

Biomimetic Metal–Organic Framework Nanoparticles for Cooperative Combination of Antiangiogenesis and Photodynamic Therapy for Enhanced Efficacy

Min, H., Wang, J., Qi, Y., Zhang, Y., Han, X., Xu, Y., Xu, J., Li, Y., Chen, L., Cheng, K., et al. (2019) · Advanced Materials · doi:10.1002/adma.201808200 · Cited by 394 · see citing works

Role of membrane transport in metabolism and function of glutathione in mammals

Bannai, S., & Tateishi, N. (1986) · The Journal of Membrane Biology · doi:10.1007/bf01870891 · Cited by 386 · see citing works

Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics

Wang, S., Li, F., Qiao, R., Hu, X., Liao, H., Chen, L., Wu, J., Wu, H., Zhao, M. L., Liu, J., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b06399 · Cited by 384 · see citing works

Transport of glutathione and glutathione conjugates by MRP1

Cole, S. P. C., & Deeley, R. G. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.06.008 · Cited by 369 · see citing works

Multidrug Resistance Protein 1 (MRP1, ABCC1), a “Multitasking” ATP-binding Cassette (ABC) Transporter

Cole, S. P. C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.r114.609248 · Cited by 364 · see citing works

Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor

Colell, A., García‐Ruiz, C., Miranda, M., Ardite, E., Marı́, M., Morales, A., Corrales, F. J., Kaplowitz, N., & Fernández-Checa, J. C. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70034-4 · Cited by 351 · see citing works

Triggered All-Active Metal Organic Framework: Ferroptosis Machinery Contributes to the Apoptotic Photodynamic Antitumor Therapy

Meng, X., Deng, J., Liu, F., Guo, T., Liu, M., Dai, P., Fan, A., Wang, Z., & Zhao, Y. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b02904 · Cited by 339 · see citing works

Glutathione: Antioxidant Properties Dedicated to Nanotechnologies

Gaucher, C., Boudier, A., Bonetti, J., Clarot, I., Leroy, P., & Parent, M. (2018) · Antioxidants · doi:10.3390/antiox7050062 · Cited by 332 · see citing works

Synthesis of CaCO3-Based Nanomedicine for Enhanced Sonodynamic Therapy via Amplification of Tumor Oxidative Stress

Dong, Z., Feng, L., Hao, Y., Li, Q., Chen, M., Yang, Z., Zhao, H., & Liu, Z. (2020) · Chem · doi:10.1016/j.chempr.2020.02.020 · Cited by 332 · see citing works

Enhanced Photodynamic Therapy by Reduced Levels of Intracellular Glutathione Obtained By Employing a Nano‐MOF with CuII as the Active Center

Zhang, W., Lü, J., Gao, X., Li, P., Zhang, W., Ma, Y., Wang, H., & Tang, B. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201710800 · Cited by 328 · see citing works

A Mn(III)-Sealed Metal–Organic Framework Nanosystem for Redox-Unlocked Tumor Theranostics

Wan, S., Qian, C., Zeng, X., & Zhang, X. (2019) · ACS Nano · doi:10.1021/acsnano.9b00300 · Cited by 324 · see citing works

Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy

Lv, H., Zhen, C., Liu, J., Yang, P., Hu, L., & Shang, P. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3150145 · Cited by 320 · see citing works

Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology

Ballatori, N., Krance, S. M., Marchan, R., & Hammond, C. L. (2008) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2008.08.004 · Cited by 318 · see citing works

Targeted exosome‐encapsulated erastin induced ferroptosis in triple negative breast cancer cells

Yu, M., Gai, C., Li, Z., Ding, D., Zheng, J., Zhang, W.-F., Lv, S.-J., & Li, W.-T. (2019) · Cancer Science · doi:10.1111/cas.14181 · Cited by 316 · see citing works

Enzyme‐MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy

Lian, X., Huang, Y., Zhu, Y., Fang, Y., Zhao, R., Joseph, E. A., Li, J., Pellois, J., & Zhou, H.-C. “. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201801378 · Cited by 286 · see citing works

Role of Glutathione in the Regulation of Cisplatin Resistance in Cancer Chemotherapy

Chen, H. H. W., & Kuo, M. T. (2010) · Metal-Based Drugs · doi:10.1155/2010/430939 · Cited by 284 · see citing works

Expression of γ-glutamyltransferase in cancer cells and its significance in drug resistance

Alfonso Pompella, C., Tata, V. D., Paolicchi, A., & Zunino, F. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.10.005 · Cited by 280 · see citing works

Persistent Regulation of Tumor Microenvironment via Circulating Catalysis of MnFe2O4@Metal–Organic Frameworks for Enhanced Photodynamic Therapy

Yin, S., Song, G., Yang, Y., Zhao, Y., Wang, P., Zhu, L., Yin, X., & Zhang, X. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201901417 · Cited by 279 · see citing works

Self‐Assembled Single‐Site Nanozyme for Tumor‐Specific Amplified Cascade Enzymatic Therapy

Wang, D., Wu, H., Wang, C., Gu, L., Chen, H., Jana, D., Feng, L., Liu, J., Wang, X., Xu, P., et al. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202008868 · Cited by 276 · see citing works

Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine

Poursaitidis, I., Wang, X., Crighton, T., Labuschagne, C. F., Mason, D. Y., Cramer, S. L., Triplett, K., Roy, R., Pardo, O. E., Seckl, M. J., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.054 · Cited by 273 · see citing works

The glutathione cycle: Glutathione metabolism beyond the γ‐glutamyl cycle

Bachhawat, A. K., & Yadav, S. (2018) · IUBMB Life · doi:10.1002/iub.1756 · Cited by 271 · see citing works

Glutathione-Responsive Prodrug Nanoparticles for Effective Drug Delivery and Cancer Therapy

Ling, X., Tu, J., Wang, J., Shajii, A., Kong, N., Feng, C., Zhang, Y., Yu, M., Xie, T., Bharwani, Z., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b06400 · Cited by 266 · see citing works

Glutathione Metabolism during Aging and in Alzheimer Disease

LIU, H., Wang, H., Shenvi, S. V., Hagen, T. M., & LIU, R. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.059 · Cited by 258 · see citing works

Cancer-Cell-Activated Photodynamic Therapy Assisted by Cu(II)-Based Metal–Organic Framework

Wang, Y., Wu, W., Liu, J., Manghnani, P. N., Hu, F., Ma, D., Teh, C., Wang, B., & Liu, B. (2019) · ACS Nano · doi:10.1021/acsnano.9b01665 · Cited by 250 · see citing works

Programmed Release of Dihydroartemisinin for Synergistic Cancer Therapy Using a CaCO 3 Mineralized Metal–Organic Framework

Wan, X., Hui, Z., Pan, W., Li, Y., Chen, Y., Li, N., & Tang, B. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201907388 · Cited by 247 · see citing works

Nitric oxide as an all-rounder for enhanced photodynamic therapy: Hypoxia relief, glutathione depletion and reactive nitrogen species generation

Deng, Y., Jia, F., Chen, S., Shen, Z., Jin, Q., Fu, G., & Ji, J. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.09.043 · Cited by 245 · see citing works

Polyrotaxane-based supramolecular theranostics

Yu, G., Yáng, Z., Fu, X., Yung, B. C., Yang, J., Mao, Z., Shao, L., Hua, B., Liu, Y., Zhang, F., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03119-w · Cited by 240 · see citing works

Illuminating Platinum Transportation while Maximizing Therapeutic Efficacy by Gold Nanoclusters via Simultaneous Near-Infrared-I/II Imaging and Glutathione Scavenging

Yang, Y., Yu, Y., Chen, H., Meng, X., Ma, W., Yu, M., Li, Z., Li, C., Liu, H., Zhang, X., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c05541 · Cited by 240 · see citing works

Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases

Lee, M., Cho, T., Jantaratnotai, N., Wang, Y. T., McGeer, E. G., & McGeer, P. L. (2010) · The FASEB Journal · doi:10.1096/fj.09-149997 · Cited by 239 · see citing works

Ultrasound‐Activated Oxygen and ROS Generation Nanosystem Systematically Modulates Tumor Microenvironment and Sensitizes Sonodynamic Therapy for Hypoxic Solid Tumors

Fu, J., Li, T., Zhu, Y., & Hao, Y. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201906195 · Cited by 238 · see citing works

Enhanced cancer therapy by hypoxia-responsive copper metal-organic frameworks nanosystem

Zhang, K., Meng, X., Yang, Z., Dong, H., & Zhang, X. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120278 · Cited by 235 · see citing works

Glutamate Cysteine Ligase Catalysis

Chen, Y., Shertzer, H. G., Schneider, S. N., Nebert, D. W., & Dalton, T. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504604200 · Cited by 234 · see citing works

Fusiform-Like Copper(II)-Based Metal–Organic Framework through Relief Hypoxia and GSH-Depletion Co-Enhanced Starvation and Chemodynamic Synergetic Cancer Therapy

Wang, Z., Liu, B., Sun, Q., Dong, S., Kuang, Y., Dong, Y., He, F., Gai, S., & Yang, P. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c01539 · Cited by 231 · see citing works

An Ultrasmall SnFe 2 O 4 Nanozyme with Endogenous Oxygen Generation and Glutathione Depletion for Synergistic Cancer Therapy

Feng, L., Liu, B., Xie, R., Wang, D., Qian, C., Zhou, W., Liu, J., Jana, D., Yang, P., & Zhao, Y. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202006216 · Cited by 228 · see citing works

Therapeutic Vesicular Nanoreactors with Tumor‐Specific Activation and Self‐Destruction for Synergistic Tumor Ablation

Li, J., Dirisala, A., Ge, Z., Wang, Y., Yin, W., Ke, W., Toh, K., Xie, J., Matsumoto, Y., Anraku, Y., et al. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201706964 · Cited by 220 · see citing works

A new inhibitor of glucose-6-phosphate dehydrogenase blocks pentose phosphate pathway and suppresses malignant proliferation and metastasis in vivo

Mele, L. L., Paino, F., Papaccio, F., Regad, T., Boocock, D. J., Stiuso, P., Lombardi, A., Liccardo, D., Aquino, G., Barbieri, A., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0635-5 · Cited by 215 · see citing works

Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT

Wang, Z., Ding, Y., Wang, X., Lu, S., Wang, C., He, C. H., Wang, L., Piao, M., Chi, G., Luo, Y., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.04.021 · Cited by 211 · see citing works

Light-activatable liposomes for repetitive on-demand drug release and immunopotentiation in hypoxic tumor therapy

Yang, Y., Liu, X., Ma, W., Xu, Q., Chen, G., Wang, Y., Xiao, H., Li, N., Liang, X., Yu, M., et al. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120456 · Cited by 211 · see citing works

Glutathione-Scavenging Poly(disulfide amide) Nanoparticles for the Effective Delivery of Pt(IV) Prodrugs and Reversal of Cisplatin Resistance

Ling, X., Chen, X., Riddell, I. A., Tao, W., Wang, J., Hollett, G., Lippard, S. J., Farokhzad, O. C., Shi, J., & Wu, J. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b01924 · Cited by 209 · see citing works

A radical shift in perspective: mitochondria as regulators of reactive oxygen species

Munro, D., & Treberg, J. R. (2017) · Journal of Experimental Biology · doi:10.1242/jeb.132142 · Cited by 207 · see citing works

Oxidative Stress and Antioxidants in the Pathogenesis of Pulmonary Fibrosis: A Potential Role for Nrf2

Walters, D. M., Cho, H., & Kleeberger, S. R. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1901 · Cited by 205 · see citing works

GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer

Zhou, Z., Wu, H., Yang, R., Xu, A., Zhang, Q., Dong, J., Qian, C., & Sun, M. (2020) · Science Advances · doi:10.1126/sciadv.abc4373 · Cited by 202 · see citing works

Redox Dyshomeostasis Strategy for Hypoxic Tumor Therapy Based on DNAzyme‐Loaded Electrophilic ZIFs

Li, Y., Zhao, P., Gong, T., Wang, H., Jiang, X., Cheng, H. S., Liu, Y., Wu, Y., & Bu, W. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202003653 · Cited by 198 · see citing works

Tumor Suppressor Function of the Plasma Glutathione Peroxidase Gpx3 in Colitis-Associated Carcinoma

Barrett, C. W., Wei, N., Chen, X., Smith, J. J., Washington, M. K., Hill, K. E., Coburn, L. A., Peek, R. M., Chaturvedi, R., Wilson, K. T., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-3150 · Cited by 196 · see citing works

Glutathione-mediated biotransformation in the liver modulates nanoparticle transport

Jiang, X., Du, B., & Zheng, J. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0499-6 · Cited by 190 · see citing works

Molecular targets of isothiocyanates in cancer: Recent advances

Gupta, P., Kim, B., Kim, S., & Srivastava, S. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300684 · Cited by 188 · see citing works

Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism

Ma, M.-Z., Chen, G., Wang, P., Lu, W.-H., Zhu, C.-F., Song, M., Yang, J., Wen, S., Xu, R., Hu, Y., et al. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.07.031 · Cited by 188 · see citing works

Redox-responsive nano-carriers as tumor-targeted drug delivery systems

Raza, A., Hayat, U., Rasheed, T., Bilal, M., & Iqbal, H. M. N. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.08.034 · Cited by 187 · see citing works

O 2 -Cu/ZIF-8@Ce6/ZIF-8@F127 Composite as a Tumor Microenvironment-Responsive Nanoplatform with Enhanced Photo-/Chemodynamic Antitumor Efficacy

Xie, Z., Liang, S., Cai, X., Ding, B., Huang, S., Hou, Z., Ma, P., Cheng, Z., & Lin, J. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b10685 · Cited by 187 · see citing works

Comparative in vitro cytotoxicity study of silver nanoparticle on two mammalian cell lines

Mukherjee, S. G., O’Claonadh, N., Casey, A., & Chambers, G. (2011) · Toxicology in Vitro · doi:10.1016/j.tiv.2011.12.004 · Cited by 186 · see citing works

Nanomaterial-induced ferroptosis for cancer specific therapy

Liu, M., Liu, B., Liu, Q., Du, K., Wang, Z., & He, N. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2018.12.015 · Cited by 180 · see citing works

Dual GSH-exhausting sorafenib loaded manganese-silica nanodrugs for inducing the ferroptosis of hepatocellular carcinoma cells

Tang, H., Chen, D., Li, C., Zheng, C., Wu, X., Zhang, Y., Song, Q., & Fei, W. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118782 · Cited by 175 · see citing works

A mitochondria-targeting magnetothermogenic nanozyme for magnet-induced synergistic cancer therapy

Shen, J., Rees, T. W., Zhou, Z., Yang, S., Ji, L., & Chao, H. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120079 · Cited by 173 · see citing works

Reactive Oxygen Species–Activatable Liposomes Regulating Hypoxic Tumor Microenvironment for Synergistic Photo/Chemodynamic Therapies

Zhao, Z., Wang, W., Li, C., Zhang, Y., Yu, T., Wu, R., Zhao, J., Liu, Z., Liu, J., & Yu, H. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201905013 · Cited by 171 · see citing works

Redox Responsive Metal Organic Framework Nanoparticles Induces Ferroptosis for Cancer Therapy

He, H., Du, L., Guo, H., An, Y., Lu, L., Chen, Y., Wang, Y., Zhong, H., Shen, J., Wu, J., et al. (2020) · Small · doi:10.1002/smll.202001251 · Cited by 164 · see citing works

Tumor-specific carrier-free nanodrugs with GSH depletion and enhanced ROS generation for endogenous synergistic anti-tumor by a chemotherapy-photodynamic therapy

Lan, J., Liu, L., Zeng, R., Qin, Y.-H., Hou, J., Xie, S., Yue, S., Yang, J., Ho, R. J. Y., Ding, Y., et al. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.127212 · Cited by 164 · see citing works

Reactive oxygen species and endothelial function in diabetes

Fatehi‐Hassanabad, Z., Chan, C. B., & Furman, B. L. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.03.048 · Cited by 163 · see citing works

Inhibition of NADP dependent oxidoreductases by the 6‐aminonicotinamide analogue of NADP

Köhler, E., Barrach, H.-J., & Neubert, D. (1970) · FEBS Letters · doi:10.1016/0014-5793(70)80063-1 · Cited by 163 · see citing works

Biomimetic CoO@AuPt nanozyme responsive to multiple tumor microenvironmental clues for augmenting chemodynamic therapy

Fu, S., Yang, R., Zhang, L., Liu, W., Du, G., Cao, Y., Xu, Z., Cui, H., Kang, Y., & Xue, P. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120279 · Cited by 163 · see citing works

Erastin/sorafenib induces cisplatin‑resistant non‑small cell lung cancer cell ferroptosis through inhibition of the Nrf2/xCT pathway

Li, Y., Yan, H., Xu, X., Liu, H., Wu, C., & Zhao, L. (2019) · Oncology Letters · doi:10.3892/ol.2019.11066 · Cited by 159 · see citing works

Chemical Insights in the Concept of Hybrid Drugs: The Antitumor Effect of Nitric Oxide-Donating Aspirin Involves A Quinone Methide but Not Nitric Oxide nor Aspirin

Hulsman, N., Medema, J. P., Bos, C. L., Jongejan, A., Leurs, R., Smit, M. J., de Esch, I. J. P., Richel, D. J., & Wijtmans, M. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm061371e · Cited by 157 · see citing works

Fe(III)‐Porphyrin Sonotheranostics: A Green Triple‐Regulated ROS Generation Nanoplatform for Enhanced Cancer Imaging and Therapy

Zhu, J. X., Chu, C., Li, D., Pang, X., Zheng, H., Wang, J., Shi, Y., Zhang, Y., Cheng, Y., Ren, E., et al. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201904056 · Cited by 156 · see citing works

Nano-decocted ferrous polysulfide coordinates ferroptosis-like death in bacteria for anti-infection therapy

Shen, X., Ma, R., Huang, Y., Chen, L., Xu, Z., Li, D., Meng, X., Fan, K., Xi, J., Yan, X., et al. (2020) · Nano Today · doi:10.1016/j.nantod.2020.100981 · Cited by 154 · see citing works

Targeting Glutathione Metabolism: Partner in Crime in Anticancer Therapy

Desideri, E., Ciccarone, F., & Ciriolo, M. R. (2019) · Nutrients · doi:10.3390/nu11081926 · Cited by 153 · see citing works

Tumor-Specific Expansion of Oxidative Stress by Glutathione Depletion and Use of a Fenton Nanoagent for Enhanced Chemodynamic Therapy

Chen, Q., Zhou, J., Chen, Z., Luo, Q., Xu, J., & Song, G. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b09323 · Cited by 152 · see citing works

MRP1 and its role in anticancer drug resistance

Lu, J. F., Pokharel, D., & Bebawy, M. (2015) · Drug Metabolism Reviews · doi:10.3109/03602532.2015.1105253 · Cited by 151 · see citing works

An inorganic prodrug, tellurium nanowires with enhanced ROS generation and GSH depletion for selective cancer therapy

Wu, Y., Guo, T., Qiu, Y., Lin, Y., Yao, Y., Lian, W., Lin, L., Song, J., & Yang, H. (2019) · Chemical Science · doi:10.1039/c9sc01070j · Cited by 151 · see citing works

Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity

Xu, Y., Han, X., Li, Y., Min, H., Zhao, X., Zhang, Y., Qi, Y., Shi, J. Y., Qi, S., Bao, Y., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b07032 · Cited by 147 · see citing works

Stimuli-responsive nanoscale drug delivery systems for cancer therapy

Li, L., Yang, W., & Xu, D. (2018) · Journal of drug targeting · doi:10.1080/1061186x.2018.1519029 · Cited by 143 · see citing works

Isothiocyanates and plant polyphenols as inhibitors of lung and esophageal cancer

Stoner, G. D., & Morse, M. A. (1997) · Cancer Letters · doi:10.1016/s0304-3835(97)04639-9 · Cited by 142 · see citing works

Redox regulation of gamma-glutamyl transpeptidase.

Zhang, H.-Q., & Forman, H. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0169tr · Cited by 140 · see citing works

Glutathione antioxidant system and methylmercury-induced neurotoxicity: An intriguing interplay

Farina, M., & Aschner, M. (2019) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2019.01.007 · Cited by 137 · see citing works

Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility

Larraufie, M., Yang, W. S., Jiang, E., Thomas, A. G., Slusher, B. S., & Stockwell, B. R. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.07.018 · Cited by 135 · see citing works

Targeted Manganese doped silica nano GSH-cleaner for treatment of Liver Cancer by destroying the intracellular redox homeostasis

Tang, H., Li, C., Zhang, Y., Zheng, H., Cheng, Y., Zhu, J., Chen, X., Zhu, Z., Piao, J., & Li, F. (2020) · Theranostics · doi:10.7150/thno.46771 · Cited by 134 · see citing works

Surface-Charge-Switchable Nanoclusters for Magnetic Resonance Imaging-Guided and Glutathione Depletion-Enhanced Photodynamic Therapy

Zhu, J., Xiao, T., Zhang, J., Che, H., Shi, Y., Shi, X., & van Hest, J. C. M. (2020) · ACS Nano · doi:10.1021/acsnano.0c03080 · Cited by 130 · see citing works

A Smart Nanoparticle-Laden and Remote-Controlled Self-Destructive Macrophage for Enhanced Chemo/Chemodynamic Synergistic Therapy

Sun, P., Deng, Q., Kang, L., Sun, Y., Ren, J., & Qu, X. (2020) · ACS Nano · doi:10.1021/acsnano.0c06290 · Cited by 128 · see citing works

Verapamil and Its Derivative Trigger Apoptosis through Glutathione Extrusion by Multidrug Resistance Protein MRP1

Trompier, D., Chang, X.-B., Barattin, R., d′Hardemare, A. D. M., Pietro, A. D., & Baubichon-Cortay, H. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0143 · Cited by 127 · see citing works

Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death

Catanzaro, D., Gaude, E., Orso, G., Giordano, C., Guzzo, G., Rasola, A., Ragazzi, E., Caparrotta, L., Frezza, C., & Montopoli, M. (2015) · Oncotarget · doi:10.18632/oncotarget.4945 · Cited by 126 · see citing works

Multifaceted Roles of Glutathione and Glutathione-Based Systems in Carcinogenesis and Anticancer Drug Resistance

Hatem, E., Banna, N. E., & Huang, M. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7134 · Cited by 126 · see citing works

Bioflavonoid Stimulation of Glutathione Transport by the 190-kDa Multidrug Resistance Protein 1 (MRP1)

Leslie, E. M., Deeley, R. G., & Cole, S. P. C. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.1.11 · Cited by 124 · see citing works

Drug metabolizing enzymes and their inhibitors' role in cancer resistance

Pathania, S., Bhatia, R., Baldi, A., Singh, R., & Rawal, R. K. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.117 · Cited by 123 · see citing works

Programmed degradation of a hierarchical nanoparticle with redox and light responsivity for self-activated photo-chemical enhanced chemodynamic therapy

Wang, S., Yang, L., Cho, H., Chueng, S. D., Zhang, H., Zhang, Q., & Lee, K. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119498 · Cited by 122 · see citing works

The balance between NRF2/GSH antioxidant mediated pathway and DNA repair modulates cisplatin resistance in lung cancer cells

Silva, M. M., Rocha, C. R. R., Kinker, G. S., Pelegrini, A. L., & Menck, C. F. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-54065-6 · Cited by 122 · see citing works

Stepwise Degradable Nanocarriers Enabled Cascade Delivery for Synergistic Cancer Therapy

Yang, Y., Lu, Y., Abbaraju, P. L., Azimi, I., Lei, C., Tang, J., Jambhrunkar, M., Fu, J., Zhang, M., Liu, Y., et al. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201800706 · Cited by 120 · see citing works

Sanguinarine-induced apoptosis is associated with an early and severe cellular glutathione depletion

Débiton, E., Madelmont, J., Legault, J., & Barthomeuf, C. (2003) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-003-0609-9 · Cited by 118 · see citing works

Multifunctional FeS2 theranostic nanoparticles for photothermal-enhanced chemodynamic/photodynamic cancer therapy and photoacoustic imaging

Xiao, S., Lu, Y., Feng, M., Dong, M., Cao, Z., Zhang, X., Chen, Y., & Liu, J. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.125294 · Cited by 117 · see citing works

Oxidative stress contributes to gold nanoparticle-induced cytotoxicity in human tumor cells

Mateo, D., Morales, P., Ávalos, A., & Haza, A. I. (2013) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2013.869783 · Cited by 116 · see citing works

A novel Mn–Cu bimetallic complex for enhanced chemodynamic therapy with simultaneous glutathione depletion

Cao, S., Fan, J., Sun, W. C., Li, F., Li, K., Tai, X., & Peng, X. (2019) · Chemical Communications · doi:10.1039/c9cc06040e · Cited by 116 · see citing works

Glutathione-Depleting Gold Nanoclusters for Enhanced Cancer Radiotherapy through Synergistic External and Internal Regulations

Zhang, X., Chen, X., Jiang, Y., Ma, N., Xia, L.-Y., Cheng, X., Jia, H., Liu, P., Gu, N., Chen, Z., et al. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b00207 · Cited by 115 · see citing works

A redox-triggered C-centered free radicals nanogenerator for self-enhanced magnetic resonance imaging and chemodynamic therapy

Chen, J., Wang, X., Zhang, Y., Zhang, S., Liu, H., Zhang, J., Feng, H., Li, B., Wu, X., Gao, Y., et al. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120457 · Cited by 115 · see citing works

Glutathione Depletion in a Benign Manner by MoS2‐Based Nanoflowers for Enhanced Hypoxia‐Irrelevant Free‐Radical‐Based Cancer Therapy

Wu, S., Liu, X., Ren, J., & Qu, X. (2019) · Small · doi:10.1002/smll.201904870 · Cited by 114 · see citing works

Glutathione compartmentalization and its role in glutathionylation and other regulatory processes of cellular pathways

Scirè, A., Cianfruglia, L., Minnelli, C., Bartolini, D., Torquato, P., Principato, G., Galli, F., & Armeni, T. (2018) · BioFactors · doi:10.1002/biof.1476 · Cited by 113 · see citing works

Potentiating photodynamic therapy of ICG-loaded nanoparticles by depleting GSH with PEITC

Hu, H., Chen, J., Yang, H., Huang, X., Wu, H., Wu, Y., Li, F., Yi, Y., Xiao, C., Li, Y., et al. (2019) · Nanoscale · doi:10.1039/c9nr01306g · Cited by 113 · see citing works

Modulating Endogenous NQO1 Levels Identifies Key Regulatory Mechanisms of Action of β-Lapachone for Pancreatic Cancer Therapy

Li, L. S., Bey, E. A., Dong, Y., Meng, J., Patra, B., Yan, J., Xie, X., Brekken, R. A., Barnett, C. C., Bornmann, W. G., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-1983 · Cited by 111 · see citing works

Sulfasalazine‐induced cystine starvation: Potential use for prostate cancer therapy

Doxsee, D. W., Gout, P. W., Kurita, T., Lo, M., Buckley, A. R., Wang, Y., Xue, H., Karp, C. M., Cutz, J., Cunha, G. R., et al. (2006) · The Prostate · doi:10.1002/pros.20508 · Cited by 111 · see citing works

Rapid Activation of Glutamate Cysteine Ligase following Oxidative Stress

Krejsa, C. M., Franklin, C. C., White, C. C., Ledbetter, J. A., Schieven, G. L., & Kavanagh, T. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.116210 · Cited by 111 · see citing works

Metal–Organic Framework Derived Multicomponent Nanoagent as a Reactive Oxygen Species Amplifier for Enhanced Photodynamic Therapy

Wang, D., Wu, H., Yang, G., Qian, C., Gu, L., Wang, H., Zhou, W., Liu, J., Wu, Y., Zhang, X., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c05499 · Cited by 108 · see citing works

Bimetallic Oxide FeWOX Nanosheets as Multifunctional Cascade Bioreactors for Tumor Microenvironment‐Modulation and Enhanced Multimodal Cancer Therapy

Gong, F., Chen, M., Yang, N., Dong, Z., Tian, L., Hao, Y., Zhuo, M., Liu, Z., Chen, Q., & Cheng, L. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202002753 · Cited by 104 · see citing works

Copper ferrite heterojunction coatings empower polyetheretherketone implant with multi-modal bactericidal functions and boosted osteogenicity through synergistic photo/Fenton-therapy

Zhang, J., Gao, X., Ma, D., He, S., Du, B., Yang, W., Xie, K., Xie, L., & Deng, Y. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.130094 · Cited by 104 · see citing works

Ferroptosis: A Novel Mechanism of Artemisinin and its Derivatives in Cancer Therapy

Zhu, S., Yu, Q., Huo, C., Li, Y., He, L., Ran, B., Chen, J., Li, Y., & Liu, W. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200121124404 · Cited by 103 · see citing works

Tumor Microenvironment-triggered Nanosystems as dual-relief Tumor Hypoxia Immunomodulators for enhanced Phototherapy

Shen, Z., Xia, J., Ma, Q., Zhu, W., Gao, Z., Han, S., Liang, Y., Cao, J., & Sun, Y. Y. (2020) · Theranostics · doi:10.7150/thno.46076 · Cited by 103 · see citing works

Intracellular glutathione-depleting polymeric micelles for cisplatin prodrug delivery to overcome cisplatin resistance of cancers

Han, Y., Yin, W., Li, J., Zhao, H. L., Zha, Z., Ke, W., Wang, Y., He, C., & Ge, Z. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.01.019 · Cited by 102 · see citing works

Near-Infrared Light Irradiation Induced Mild Hyperthermia Enhances Glutathione Depletion and DNA Interstrand Cross-Link Formation for Efficient Chemotherapy

Zhang, J., Zhao, B., Chen, S., Wang, Y., Zhang, Y., Wang, Y., Wei, D., Zhang, L., Rong, G., Weng, Y., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c03781 · Cited by 101 · see citing works

Self-Delivered and Self-Monitored Chemo-Photodynamic Nanoparticles with Light-Triggered Synergistic Antitumor Therapies by Downregulation of HIF-1α and Depletion of GSH

Zhang, Z., Wang, R., Huang, X., Luo, R., Xue, J., Gao, J., Liu, W., Liu, F., Feng, F., & Qu, W. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b23325 · Cited by 100 · see citing works

Photothermal-reinforced and glutathione-triggered in Situ cascaded nanocatalytic therapy

An, P., Fan, F., Gu, D., Gao, Z., Hossain, A. M. S., & Sun, B. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.03.007 · Cited by 100 · see citing works

Specificity of steroid interaction with mammary glucose 6-phosphate dehydrogenase

Raineri, R. R., & Levy, H. (1970) · Biochemistry · doi:10.1021/bi00813a003 · Cited by 99 · see citing works

N-Acetylcysteine for the Treatment of Psychiatric Disorders: A Review of Current Evidence

Ooi, S. L., Green, R., & Pak, S. C. (2018) · BioMed Research International · doi:10.1155/2018/2469486 · Cited by 99 · see citing works

Photothermal-Enhanced Inactivation of Glutathione Peroxidase for Ferroptosis Sensitized by an Autophagy Promotor

An, P., Gao, Z., Sun, K., Gu, D., Wu, H., You, C., Li, Y., Cheng, K., Zhang, Y., Wang, Z., et al. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b16124 · Cited by 98 · see citing works

Small size gold nanoparticles enhance apoptosis-induced by cold atmospheric plasma via depletion of intracellular GSH and modification of oxidative stress

Jawaid, P., Rehman, M. U., Zhao, Q., Misawa, M., Ishikawa, K., Hori, M., Shimizu, T., Saitoh, J., Noguchi, K., & Kondo, T. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-00314-x · Cited by 97 · see citing works

Tumor-specific activated photodynamic therapy with an oxidation-regulated strategy for enhancing anti-tumor efficacy

Liang, H., Zhou, Z., Luo, R., Sang, M., Liu, B., Sun, M., Qu, W., Feng, F., & Liu, W. (2018) · Theranostics · doi:10.7150/thno.28344 · Cited by 91 · see citing works

Reactive oxygen species-responsive nanoprodrug with quinone methides-mediated GSH depletion for improved chlorambucil breast cancers therapy

Luo, C.-Q., Zhou, Y., Zhou, T., Xing, L., Cui, P., Sun, M., Jin, L., Lu, N., & Jiang, H. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.01.034 · Cited by 90 · see citing works

Three birds with one stone: A ferric pyrophosphate based nanoagent for synergetic NIR-triggered photo/chemodynamic therapy with glutathione depletion

Huang, Y., Jiang, Y., Xiao, Z., Shen, Y., Huang, L., Xu, X., Wei, G., Xu, C., & Zhao, C. (2019) · Chemical Engineering Journal · doi:10.1016/j.cej.2019.122369 · Cited by 90 · see citing works

GSH-activated MRI-guided enhanced photodynamic- and chemo-combination therapy with a MnO 2 -coated porphyrin metal organic framework

Tian, X., Cao, P., Zhang, H., Li, Y., & Yin, X. (2019) · Chemical Communications · doi:10.1039/c9cc01957j · Cited by 89 · see citing works

Copper-Doped Nanoscale Covalent Organic Polymer for Augmented Photo/Chemodynamic Synergistic Therapy and Immunotherapy

Hu, C., Cai, L., Liu, S., Liu, Y., Zhou, Y., & Pang, M. (2020) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.0c00209 · Cited by 88 · see citing works

Protection of NRK-52E Cells, a Rat Renal Proximal Tubular Cell Line, from Chemical-Induced Apoptosis by Overexpression of a Mitochondrial Glutathione Transporter

Lash, L. H., Putt, D. A., & Matherly, L. H. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.040220 · Cited by 87 · see citing works

Current Developments in Pt(IV) Prodrugs Conjugated with Bioactive Ligands

Li, X., Liu, Y., & Tian, H. (2018) · Bioinorganic Chemistry and Applications · doi:10.1155/2018/8276139 · Cited by 86 · see citing works

Chrysin enhances doxorubicin-induced cytotoxicity in human lung epithelial cancer cell lines: The role of glutathione

Brechbuhl, H. M., Kachadourian, R., Min, E., Chan, D. C. F., & Day, B. J. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.08.004 · Cited by 86 · see citing works

Metadherin enhances vulnerability of cancer cells to ferroptosis

Bi, J., Yang, S., Long, L., Dai, Q., Borcherding, N. C., Wagner, B. A., Buettner, G. R., Spitz, D. R., Leslie, K. K., Zhang, J., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1897-2 · Cited by 84 · see citing works

Tumor microenvironment-induced structure changing drug/gene delivery system for overcoming delivery-associated challenges

Zhang, M., Guo, X., Wang, M., & Liu, K. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.04.026 · Cited by 84 · see citing works

Integrated Nanoparticles To Synergistically Elevate Tumor Oxidative Stress and Suppress Antioxidative Capability for Amplified Oxidation Therapy

Yin, W., Li, J., Ke, W., Zha, Z., & Ge, Z. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b08347 · Cited by 79 · see citing works

A pH-activated autocatalytic nanoreactor for self-boosting Fenton-like chemodynamic therapy

Wu, H., Chen, F., Gu, D., You, C., & Sun, B. (2020) · Nanoscale · doi:10.1039/d0nr03135f · Cited by 79 · see citing works

Bcl-2 and Glutathione Depletion Sensitizes B16 Melanoma to Combination Therapy and Eliminates Metastatic Disease

Mena, S., Benlloch, M., Ortega, Á., Carretero, J., Obrador, E., Asensi, M. A., Petschen, I., Brown, B. D., & Estrela, J. M. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2642 · Cited by 78 · see citing works

Modulation of GSH levels in ABCC1 expressing tumor cells triggers apoptosis through oxidative stress

Laberge, R.-M., Karwatsky, J., Lincoln, M. C., Leimanis, M. L., & Georges, E. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.02.005 · Cited by 75 · see citing works

Enhancement of cisplatin efficacy by lipid–CaO 2 nanocarrier-mediated comprehensive modulation of the tumor microenvironment

He, C., Zhang, X., Yan, R., Zhao, P., Chen, Y., Li, M., Chen, C., Fan, T., Lu, Y., Wang, C., et al. (2019) · Biomaterials Science · doi:10.1039/c9bm00797k · Cited by 75 · see citing works

Inability to Maintain GSH Pool in G6PD-Deficient Red Cells Causes Futile AMPK Activation and Irreversible Metabolic Disturbance

Tang, H.-Y., Ho, H., Wu, P., Chen, S., Kuypers, F. A., Cheng, M., & Chiu, D. T.-Y. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6142 · Cited by 73 · see citing works

Thiol Reactivity and Its Impact on the Ciliate Toxicity of α,β-Unsaturated Aldehydes, Ketones, and Esters

Böhme, A., Thaens, D., Schramm, F., Paschke, A., & Schüürmann, G. (2010) · Chemical Research in Toxicology · doi:10.1021/tx100226n · Cited by 72 · see citing works

A simultaneously GSH-depleted bimetallic Cu( ii ) complex for enhanced chemodynamic cancer therapy

Cao, S., Li, X., Gao, Y., Li, F., Li, K., Cao, X., Dai, Y., Mao, L., Wang, S., & Tai, X. (2020) · Dalton Transactions · doi:10.1039/d0dt01742f · Cited by 72 · see citing works

Directly targeting glutathione peroxidase 4 may be more effective than disrupting glutathione on ferroptosis-based cancer therapy

Wei, Y., Lv, H., Shaikh, A. B., Han, W., Hou, H., Zhang, Z., Wang, S., & Shang, P. (2020) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129539 · Cited by 71 · see citing works

Non‐Fenton‐Type Hydroxyl Radical Generation and Photothermal Effect by Mitochondria‐Targeted WSSe/MnO2 Nanocomposite Loaded with Isoniazid for Synergistic Anticancer Treatment

Cheng, Y., Yang, F., Zhang, K., Zhang, Y., Cao, Y., Liu, C., Lu, H., Dong, H., & Zhang, X. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201903850 · Cited by 71 · see citing works

A ratiometric fluorescent probe for real-time monitoring of intracellular glutathione fluctuations in response to cisplatin

Liu, H., Song, W., Zhang, S., Chan, K. S., Guo, Z., & Shen, Z. (2020) · Chemical Science · doi:10.1039/d0sc02889d · Cited by 71 · see citing works

A homogenous nanoporous pulmonary drug delivery system based on metal-organic frameworks with fine aerosolization performance and good compatibility

Zhou, Y., Niu, B., Wu, B., Luo, S., Fu, J., Zhao, Y., Quan, G., Pan, X., & Wu, C. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.07.018 · Cited by 71 · see citing works

Glutathione Depletion and Disruption of Intracellular Ionic Homeostasis Regulate Lymphoid Cell Apoptosis

Franco, R., DeHaven, W. I., Sifre, M. I., Bortner, C. D., & Cidlowski, J. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807061200 · Cited by 70 · see citing works

Markedly enhanced colon tumorigenesis in Apc Min mice lacking glutathione S-transferase Pi

Ritchie, K. J., Walsh, S. V., Sansom, O. J., Henderson, C. J., & Wolf, C. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911351106 · Cited by 69 · see citing works

A glutathione-activatable nanoplatform for enhanced photodynamic therapy with simultaneous hypoxia relief and glutathione depletion

Liu, F., Gong, S., Shen, M., He, T., Liang, X., Shu, Y., Wang, X., Ma, S., Li, X., Zhang, M., et al. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.126305 · Cited by 67 · see citing works

GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway

Li, J., Wang, Q., Yang, Y., Lei, C., Yang, F., Liang, L., Chen, C., Xia, J. L., Wang, K., & Tang, N. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1459-6 · Cited by 66 · see citing works

The Anti-cancer Drug Chlorambucil as a Substrate for the Human Polymorphic Enzyme Glutathione Transferase P1-1: Kinetic Properties and Crystallographic Characterisation of Allelic Variants

Parker, L. J., Ciccone, S., Italiano, L. C., Primavera, A., Oakley, A. J., Morton, C. J., Hancock, N. C., Bello, M. L., & Parker, M. W. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.04.066 · Cited by 63 · see citing works

A novel versatile yolk-shell nanosystem based on NIR-elevated drug release and GSH depletion-enhanced Fenton-like reaction for synergistic cancer therapy

Gu, D., An, P., He, X., Wu, H., Gao, Z., Li, Y., Chen, F., Cheng, K., Zhang, Y., You, C., et al. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.110810 · Cited by 63 · see citing works

Yolk‐Shell Structured Nanoflowers Induced Intracellular Oxidative/Thermal Stress Damage for Cancer Treatment

Liu, M., Guo, D., Zeng, R., Ye, J., Wang, S., Li, C., Sun, Y., Cheng, S., & Zhang, X. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202006098 · Cited by 63 · see citing works

Tyrosinase-activated prodrug nanomedicine as oxidative stress amplifier for melanoma-specific treatment

Pu, Y., Zhou, B., Xiang, H., Wu, W., Yin, H., Yue, W., Yin, Y., Li, H., Chen, Y., & Xu, H. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120329 · Cited by 62 · see citing works

Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells

Gao, F., Liu, F., Wei, W., LIU, L.-B., Xu, M., Zhu-ying, G., Li, W., Jiang, B., & Wu, Y. (2012) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2012.895 · Cited by 60 · see citing works

Hypoxia- and singlet oxygen-responsive chemo-photodynamic Micelles featured with glutathione depletion and aldehyde production

Deng, J., Liu, F., Wang, L., An, Y., Gao, M., Wang, Z., & Zhao, Y. (2018) · Biomaterials Science · doi:10.1039/c8bm01042k · Cited by 60 · see citing works

Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation

Zhao, Y. M., Seefeldt, T. M., Chen, W., Carlson, L. T., Stoebner, A., Hanson, S., Foll, R., Matthees, D. P., Palakurthi, S., & Guan, X. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.04.022 · Cited by 59 · see citing works

Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non‐small‐cell lung cancer

Otsubo, K., Nosaki, K., Imamura, C. K., Ogata, H., Fujita, A., Sakata, S., Hirai, F., Toyokawa, G., Iwama, E., Harada, T., et al. (2017) · Cancer Science · doi:10.1111/cas.13309 · Cited by 58 · see citing works

Near Infrared‐Activatable Platinum‐Decorated Gold Nanostars for Synergistic Photothermal/Ferroptotic Therapy in Combating Cancer Drug Resistance

del Valle, A. C., Yeh, C., & Huang, Y. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000864 · Cited by 57 · see citing works

-Glutamyl Transpeptidase Mediation of Tumor Glutathione Utilization In Vivo

Hochwald, S. N., Harrison, L. E., Rose, D. M., Anderson, M. E., & BURT, M. E. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.3-4.193 · Cited by 57 · see citing works

Curcumin inhibited growth of human melanoma A375 cells via inciting oxidative stress

Liao, W., Xiang, W., Wang, F., Wang, R., & Ding, Y. P. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.09.026 · Cited by 54 · see citing works

Iron Homeostasis and Ferroptosis in Human Diseases: Mechanisms and Therapeutic Prospects

Ru, Q., Li, Y., Chen, L., Wu, Y., Min, J., & Wang, F. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01969-z · Cited by 724 · see citing works

Cellular zinc metabolism and zinc signaling: From biological functions to diseases and therapeutic targets

Chen, B., Yu, P., Chan, W. N., Xie, F., Zhang, Y., Liang, L., Leung, K. T., Lo, K. W., Yu, J., Tse, G. M. K., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01679-y · Cited by 420 · see citing works

Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy

Zheng, P., Zhou, C., Lu, L., Liu, B., & Ding, Y. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02485-0 · Cited by 360 · see citing works

Ferroptosis Detection: From Approaches to Applications

Zeng, F., Nijiati, S., Tang, L., Ye, J., Zhou, Z., & Chen, X. S. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202300379 · Cited by 312 · see citing works

A Hollow Amorphous Bimetal Organic Framework for Synergistic Cuproptosis/Ferroptosis/Apoptosis Anticancer Therapy via Disrupting Intracellular Redox Homeostasis and Copper/Iron Metabolisms

Xu, W., Qian, J., Hou, G., Wang, T., Wang, J., Wang, Y., Yang, L., Cui, X., & Suo, A. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202205013 · Cited by 270 · see citing works

Drug-induced oxidative stress in cancer treatments: Angel or devil?

Jiang, H., Zuo, J., Li, B., Chen, R., Luo, K., Xiang, X., Lu, S., Huang, C., Liu, L., Tang, J., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102754 · Cited by 242 · see citing works

Nanoarchitectonics of in Situ Antibiotic-Releasing Acicular Nanozymes for Targeting and Inducing Cuproptosis-like Death to Eliminate Drug-Resistant Bacteria

Hu, Z., Shan, J., Jin, X., Sun, W., Cheng, L., Chen, X., & Wang, X. (2024) · ACS Nano · doi:10.1021/acsnano.4c06565 · Cited by 211 · see citing works

Copper-Based Metal–Organic Framework Overcomes Cancer Chemoresistance through Systemically Disrupting Dynamically Balanced Cellular Redox Homeostasis

Liu, J., Yuan, Y., Cheng, Y., Fu, D., Chen, Z., Wang, Y., Zhang, L., Yao, C., Shi, L., Li, M., et al. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.1c11856 · Cited by 205 · see citing works

Stimuli-activatable nanomedicine meets cancer theranostics

Li, H., Feng, Y., Luo, Q., Li, Z., Li, X., Gan, H., Gu, Z., Gong, Q., & Luo, K. (2023) · Theranostics · doi:10.7150/thno.87854 · Cited by 203 · see citing works

A Biodegradable Iridium(III) Coordination Polymer for Enhanced Two‐Photon Photodynamic Therapy Using an Apoptosis–Ferroptosis Hybrid Pathway

Ke, L., Wei, F., Xie, L., Karges, J., Chen, Y., Ji, L., & Chao, H. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202205429 · Cited by 195 · see citing works

Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression

Hu, J., Wang, S., Hou, Y., Chen, Z., Liu, L., Li, R., Li, N., Zhou, L., Yang, Y., Wang, L., et al. (2024) · Nature Genetics · doi:10.1038/s41588-024-01662-5 · Cited by 195 · see citing works

Molecular mechanisms and therapeutic strategies in overcoming chemotherapy resistance in cancer

Gu, Y., Yang, R., Zhang, Y., Guo, M., Takehiro, K., Zhan, M., Yang, L., & Wang, H. (2025) · Molecular Biomedicine · doi:10.1186/s43556-024-00239-2 · Cited by 184 · see citing works

Copper-doped MOF-based nanocomposite for GSH depleted chemo/photothermal/chemodynamic combination therapy

Wang, L., Xu, Y., Liu, C., Si, W., Wang, W., Zhang, Y., Zhong, L., Dong, X., & Zhao, Y. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.135567 · Cited by 168 · see citing works

MnOOH-Catalyzed Autoxidation of Glutathione for Reactive Oxygen Species Production and Nanocatalytic Tumor Innate Immunotherapy

Zhu, P., Pu, Y., Wang, M., Wu, W., Qin, H., & Shi, J. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.2c12942 · Cited by 158 · see citing works

Strategic Design of Conquering Hypoxia in Tumor for Advanced Photodynamic Therapy

Zhang, C., Hu, X., Jin, L., Lin, L., Lin, H., Yáng, Z., & Huang, W. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300530 · Cited by 158 · see citing works

Tumor Microenvironment-Activable Manganese-Boosted Catalytic Immunotherapy Combined with PD-1 Checkpoint Blockade

Zhao, Z., Dong, S., Liu, Y., Wang, J., Ba, L., Zhang, C., Cao, X., Wu, C., & Yang, P. (2022) · ACS Nano · doi:10.1021/acsnano.2c06646 · Cited by 152 · see citing works

Rational Design of Platinum–Bismuth Sulfide Schottky Heterostructure for Sonocatalysis‐Mediated Hydrogen Therapy

Yuan, M., Liang, S., Yang, L., Li, F., Liu, B., Yang, C., Yang, Z., Bian, Y., Ma, P., Cheng, Z., et al. (2022) · Advanced Materials · doi:10.1002/adma.202209589 · Cited by 147 · see citing works

Glutathione metabolism in ferroptosis and cancer therapy

Xue, X., Wang, M., Cui, J., Yang, M., Ma, L., Kang, R., Tang, D., & Wang, J. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217697 · Cited by 154 · see citing works

Precise modulation and use of reactive oxygen species for immunotherapy

Li, X., Gao, J., Wu, C., Wang, C., Zhang, R., He, J., Xia, Z. J., Joshi, N., Karp, J. M., & Kuai, R. (2024) · Science Advances · doi:10.1126/sciadv.adl0479 · Cited by 140 · see citing works

Emerging nitric oxide gas‐assisted cancer photothermal treatment

Liang, S., Liu, Y., Zhu, H., Liao, G., Zhu, W., & Zhang, L. (2024) · Exploration · doi:10.1002/exp.20230163 · Cited by 135 · see citing works

Blocking glutathione regeneration: Inorganic NADPH oxidase nanozyme catalyst potentiates tumoral ferroptosis

Wu, C., Xu, D., Ge, M., Luo, J., Chen, L., Chen, Z., You, Y., Zhu, Y., Han, L., & Shi, J. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101574 · Cited by 129 · see citing works

Biomimetic copper single-atom nanozyme system for self-enhanced nanocatalytic tumor therapy

Zhu, D., Ling, R., Chen, H., Lyu, M., Qian, H., Wu, K., Li, G., & Wang, X. (2022) · Nano Research · doi:10.1007/s12274-022-4359-6 · Cited by 126 · see citing works

The Role of Oxidative Stress in Tumorigenesis and Progression

Li, K., Deng, Z., Lei, C., Ding, X., Li, J., & Wang, C. (2024) · Cells · doi:10.3390/cells13050441 · Cited by 126 · see citing works

Cellular Trojan Horse initiates bimetallic Fe-Cu MOF-mediated synergistic cuproptosis and ferroptosis against malignancies

Chen, K., Zhou, A., Zhou, X., He, J., Xu, Y., & Ning, X. (2024) · Science Advances · doi:10.1126/sciadv.adk3201 · Cited by 119 · see citing works

Multi‐Enzyme Mimetic MoCu Dual‐Atom Nanozyme Triggering Oxidative Stress Cascade Amplification for High‐Efficiency Synergistic Cancer Therapy

Li, Z., Ding, B., Li, J., Chen, H., Zhang, J., Tan, J., Ma, X., Han, D., Ma, P., & Lin, J. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202413661 · Cited by 119 · see citing works

Recent advances in multi-configurable nanomaterials for improved chemodynamic therapy

Lu, J., Yang, Y., Xu, Q., Lin, Y., Feng, S., Mao, Y., Wang, D., Wang, S., & Zhao, Q. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214861 · Cited by 120 · see citing works

Unleashing the power of porphyrin photosensitizers: Illuminating breakthroughs in photodynamic therapy

Akbar, A., Khan, S., Chatterjee, T., & Ghosh, M. (2023) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2023.112796 · Cited by 115 · see citing works

Glutathione Depletion‐Induced Activation of Dimersomes for Potentiating the Ferroptosis and Immunotherapy of “Cold” Tumor

Zhou, Z., Liang, H., Yang, R., Yang, Y., Dong, J., Di, Y., & Sun, M. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202202843 · Cited by 115 · see citing works

Recent Development of Copper‐Based Nanozymes for Biomedical Applications

Yu, X., Wang, Y., Zhang, J., Liu, J., Wang, A., & Ding, L. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202302023 · Cited by 113 · see citing works

Molecular mechanisms of ROS-modulated cancer chemoresistance and therapeutic strategies

Zhou, X., An, B., Lin, Y., Ni, Y., Zhao, X., & Liang, X. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115036 · Cited by 107 · see citing works

SLC7A11-ROS/αKG-AMPK axis regulates liver inflammation through mitophagy and impairs liver fibrosis and NASH progression

Lv, T., Fan, X., He, C., Zhu, S., Xiong, X., Yan, W., Liu, M., Xu, H., Shi, R., & He, Q. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103159 · Cited by 113 · see citing works

Fe(III)‐Naphthazarin Metal–Phenolic Networks for Glutathione‐Depleting Enhanced Ferroptosis–Apoptosis Combined Cancer Therapy

Liu, Z., Liu, S., Liu, B., Bian, Y., Yuan, M., Yang, C., Meng, Q., Chen, C., Ma, P., & Lin, J. (2023) · Small · doi:10.1002/smll.202207825 · Cited by 104 · see citing works

Smart Nanoplatforms Responding to the Tumor Microenvironment for Precise Drug Delivery in Cancer Therapy

Wang, Y., Deng, T., Liu, X., Fang, X., Mo, Y., Xie, N., Nie, G., Zhang, B., & Fan, X. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s459710 · Cited by 104 · see citing works

Tumor microenvironment-responsive manganese-based nanomaterials for cancer treatment

Fan, H., & Guo, Z. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215027 · Cited by 104 · see citing works

Enzyme-mimetic antioxidant nanomaterials for ROS scavenging: Design, classification, and biological applications

Zhou, S., Cai, H., He, X., Tang, Z., & Lu, S. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215536 · Cited by 101 · see citing works

Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

Sun, D., Sun, X., Zhang, X., Wu, J., Shi, X., Sun, J., Luo, C., He, Z., & Zhang, S. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400809 · Cited by 99 · see citing works

Brain‐Targeted HFn‐Cu‐REGO Nanoplatform for Site‐Specific Delivery and Manipulation of Autophagy and Cuproptosis in Glioblastoma

Jia, W., Tian, H., Jiang, J., Zhou, L., Li, L., Luo, M., Ding, N., Nice, E. C., Huang, C., & Zhang, H. (2022) · Small · doi:10.1002/smll.202205354 · Cited by 96 · see citing works

Transition metal-based nanozymes: Classification, catalytic mechanisms and emerging biomedical applications

Zhang, D., Chen, Q., Chen, Q., Zhong, W., Zhong, W., Wang, G., & Zhang, Y. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.215771 · Cited by 96 · see citing works

Self-triggered thermoelectric nanoheterojunction for cancer catalytic and immunotherapy

Xue, Y., Kang, Y., Dong, J., Li, R., Ye, J., Fan, Y., Han, J., Yu, J., Ni, G., Ji, X., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40954-y · Cited by 95 · see citing works

Designing Single‐Atom Active Sites on sp 2 ‐Carbon Linked Covalent Organic Frameworks to Induce Bacterial Ferroptosis‐Like for Robust Anti‐Infection Therapy

Sun, B., Wang, X., Ye, Z., Zhang, J., Chen, X., Zhou, N., Zhang, M., Yao, C., Wu, F., & Shen, J. (2023) · Advanced Science · doi:10.1002/advs.202207507 · Cited by 93 · see citing works

Cellular Compartmentalization, Glutathione Transport and Its Relevance in Some Pathologies

Vázquez-Meza, H., Vilchis-Landeros, M. M., Vázquez-Carrada, M., Uribe-Ramírez, D., & Matuz-Mares, D. (2023) · Antioxidants · doi:10.3390/antiox12040834 · Cited by 94 · see citing works

Self‐Assembled Copper‐Based Nanoparticles for Glutathione Activated and Enzymatic Cascade‐Enhanced Ferroptosis and Immunotherapy in Cancer Treatment

Song, W., Zeng, J., Ji, P., Han, Z., Sun, Y., & Zhang, X. (2023) · Small · doi:10.1002/smll.202301148 · Cited by 94 · see citing works

Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy

Xu, W., Guan, G., Yue, R., Dong, Z., Lei, L., Kang, H., & Song, G. (2025) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00546 · Cited by 98 · see citing works

Oxygen-boosted biomimetic nanoplatform for synergetic phototherapy/ferroptosis activation and reversal of immune-suppressed tumor microenvironment

He, Z., Zhou, H. P., Zhang, Y., Du, X., Liu, S., Ji, J., Yang, X., & Zhai, G. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121832 · Cited by 92 · see citing works

The role of ferroptosis in intervertebral disc degeneration

Fan, C., Chu, G., Yu, Z., Ji, Z., Kong, F., Yao, L., Wang, J., Geng, D., Wu, X., & Mao, H. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1219840 · Cited by 93 · see citing works

Ferroptosis promotes sonodynamic therapy: a platinum( <scp>ii</scp> )–indocyanine sonosensitizer

Lai, Y., Lu, N., Ouyang, A., Zhang, Q., & Zhang, P. (2022) · Chemical Science · doi:10.1039/d2sc02597c · Cited by 91 · see citing works

Redox dyshomeostasis strategy for tumor therapy based on nanomaterials chemistry

Wu, Y., Li, Y., Lv, G., & Bu, W. (2022) · Chemical Science · doi:10.1039/d1sc06315d · Cited by 89 · see citing works

Dynamic responsiveness of self‐assembling peptide‐based nano‐drug systems

Wang, Y., Zhan, J., Huang, J., Wang, X., Chen, Z., Yang, Z., & Li, J. (2023) · Interdisciplinary medicine · doi:10.1002/inmd.20220005 · Cited by 89 · see citing works

Cu-GA-coordination polymer nanozymes with triple enzymatic activity for wound disinfection and accelerated wound healing

Tian, H., Yan, J., Zhang, W., Li, H., Jiang, S., Qian, H., Chen, X., Dai, X., & Wang, X. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.05.048 · Cited by 89 · see citing works

Coordination Self-Assembled AuTPyP-Cu Metal–Organic Framework Nanosheets with pH/Ultrasound Dual-Responsiveness for Synergistically Triggering Cuproptosis-Augmented Chemotherapy

Bao, J., Wang, J., Chen, S., Liu, S., Wang, Z., Zhang, W., Zhao, C., Sha, Y., Yang, X., Li, Y., et al. (2024) · ACS Nano · doi:10.1021/acsnano.3c13225 · Cited by 88 · see citing works

Nanomaterial-based regulation of redox metabolism for enhancing cancer therapy

Jia, X., Wang, Y., Qiao, Y., Jiang, X., & Li, J. (2024) · Chemical Society Reviews · doi:10.1039/d4cs00404c · Cited by 87 · see citing works

Natural Compounds and Glutathione: Beyond Mere Antioxidants

Giacomo, C. D., Malfa, G. A., Tomasello, B., Bianchi, S., & Acquaviva, R. (2023) · Antioxidants · doi:10.3390/antiox12071445 · Cited by 86 · see citing works

Tumor microenvironment sensitization via dual-catalysis of carbon-based nanoenzyme for enhanced photodynamic therapy

Feng, S., Xiao, Y., Lu, J., Chen, Z., Jiang, Z., Xu, Q., Gu, W., Wang, S., & Zhao, Q. (2024) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2024.02.160 · Cited by 86 · see citing works

Iron phthalocyanine-derived nanozyme as dual reactive oxygen species generation accelerator for photothermally enhanced tumor catalytic therapy

Nan, F., Jia, Q., Xue, X., Wang, S., Liu, W., Wang, J., Ge, J., & Wang, P. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121495 · Cited by 85 · see citing works

Mechano‐Responsive Leapfrog Micelles Enable Interactive Apoptotic and Ferroptotic Cancer Therapy

Li, Y., Qin, Y., Shang, Y., Li, Y., Liu, F., Luo, J., Zhu, J., Guo, X., Wang, Z., & Zhao, Y. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202112000 · Cited by 85 · see citing works

MAFF confers vulnerability to cisplatin-based and ionizing radiation treatments by modulating ferroptosis and cell cycle progression in lung adenocarcinoma

Liang, J., Bi, G., Huang, Y., Zhao, G., Sui, Q., Zhang, H., Bian, Y., Yin, J., Wang, Q., Chen, Z., et al. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2024.101057 · Cited by 86 · see citing works

2D Catalytic Nanozyme Enables Cascade Enzyodynamic Effect‐Boosted and Ca 2+ Overload‐Induced Synergistic Ferroptosis/Apoptosis in Tumor

Wang, Z., Wang, X., Dai, X., Xu, T., Qian, X., Chang, M., & Chen, Y. (2024) · Advanced Materials · doi:10.1002/adma.202312316 · Cited by 86 · see citing works

GSH and Ferroptosis: Side-by-Side Partners in the Fight against Tumors

Jiang, Y., Glandorff, C., & Sun, M. (2024) · Antioxidants · doi:10.3390/antiox13060697 · Cited by 84 · see citing works

Iron-Containing Protein-Mimic Supramolecular Iron Delivery Systems for Ferroptosis Tumor Therapy

Liu, S., Zhang, M., Jin, H., Wang, Z., Liu, Y., Zhang, S., & Zhang, H. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c09139 · Cited by 83 · see citing works

Self-driven nanoprodrug platform with enhanced ferroptosis for synergistic photothermal-IDO immunotherapy

Huang, P. C., Yang, Y., Wang, W., Li, Z., Gao, N., Chen, H., & Zeng, X. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122157 · Cited by 83 · see citing works

Photothermally Reinforced Nanozyme Remodeling Tumor Microenvironment of Redox and Metabolic Homeostasis to Enhance Ferroptosis in Tumor Therapy

Qin, S., Zhao, H., Luo, X., Wang, F., Liu, J., Ding, Y., & Hu, Y. (2024) · ACS Nano · doi:10.1021/acsnano.4c13087 · Cited by 81 · see citing works

Cigarette tar mediates macrophage ferroptosis in atherosclerosis through the hepcidin/FPN/SLC7A11 signaling pathway

Bao, X., Luo, X., Bai, X., Lv, Y., Weng, X., Zhang, S., Leng, Y., Huang, J., Dai, X., Wang, Y., et al. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.03.006 · Cited by 80 · see citing works

Ablation of Gap Junction Protein Improves the Efficiency of Nanozyme‐Mediated Catalytic/Starvation/Mild‐Temperature Photothermal Therapy

Li, Y., Zhang, Y. X., Dong, Y., Akakuru, O. U., Yao, X., Yi, J., Li, X., Wang, L., Lou, X., Zhu, B., et al. (2023) · Advanced Materials · doi:10.1002/adma.202210464 · Cited by 80 · see citing works

Bimetallic Ions Functionalized Metal–Organic‐Framework Nanozyme for Tumor Microenvironment Regulating and Enhanced Photodynamic Therapy for Hypoxic Tumor

Pan, M., Li, P., Yu, Y., Jiang, M., Yang, X., Zhang, P., Nie, J., Hu, J., Yu, X., & Xu, L. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300821 · Cited by 80 · see citing works

Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment

Zhang, M., Sun, D., Huang, H. F., Yang, D., Song, X., Feng, W. J., Jing, X., & Chen, Y. (2024) · Advanced Materials · doi:10.1002/adma.202409663 · Cited by 80 · see citing works

An Endogenous H 2 S-Activated Nanoplatform for Triple Synergistic Therapy of Colorectal Cancer

Chen, J., Xue, F., Du, W., Yu, H., Yang, Z., Du, Q., & Chen, H. (2022) · Nano Letters · doi:10.1021/acs.nanolett.2c01346 · Cited by 79 · see citing works

Interfacial deposition of Ag nanozyme on metal-polyphenol nanosphere for SERS detection of cellular glutathione

Li, Y., Li, P., Chen, Y., Wu, Y., & Wei, J. (2023) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2023.115200 · Cited by 78 · see citing works

Emerging nanotherapeutics for facilitating photodynamic therapy

Li, S., Yang, F., Wang, Y., Du, T., & Hou, X. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.138621 · Cited by 77 · see citing works

An Update on Glutathione's Biosynthesis, Metabolism, Functions, and Medicinal Purposes

Gasmi, A., Nasreen, A., Lenchyk, L. V., Lysiuk, R., Peana, M., Shapovalova, N., Piscopo, S., Komisarenko, M. A., Shanaida, M., Smetanina, K., et al. (2023) · Current Medicinal Chemistry · doi:10.2174/0109298673251025230919105818 · Cited by 80 · see citing works

Mesoporous silica nanoparticles: Synthesis and multifaceted functionalization for controlled drug delivery

Gupta, J. R., Quadros, M., & Momin, M. M. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104305 · Cited by 74 · see citing works

Biomimetic copper-doped polypyrrole nanoparticles induce glutamine metabolism inhibition to enhance breast cancer cuproptosis and immunotherapy

Zhang, N., Ping, W., Rao, K., Zhang, Z., Huang, R., Zhu, D., Li, G., & Ning, S. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.05.045 · Cited by 74 · see citing works

Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy

Wu, X., Zhou, Z., Li, K., & Liu, S. (2024) · Advanced Science · doi:10.1002/advs.202308632 · Cited by 71 · see citing works

The Cancer Antioxidant Regulation System in Therapeutic Resistance

Gu, X., Mu, C., Zheng, R., Zhang, Z., Zhang, Q., & Liang, T. (2024) · Antioxidants · doi:10.3390/antiox13070778 · Cited by 75 · see citing works

Crosstalk between metabolism and cell death in tumorigenesis

Yang, S., Hu, C., Chen, X., Tang, Y., Li, J., Yang, H., Yang, Y., Ying, B., Xiao, X., Li, S., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-01977-1 · Cited by 71 · see citing works

MnO2-melittin nanoparticles serve as an effective anti-tumor immunotherapy by enhancing systemic immune response

Tang, S., Zhou, L., He, H., Cui, L., Ren, Z., Tai, Y., Xie, Z., Cao, Y., Meng, D., Liu, Q., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121706 · Cited by 67 · see citing works

Cigarette smoke induces the ROS accumulation and iNOS activation through deactivation of Nrf-2/SIRT3 axis to mediate the human bronchial epithelium ferroptosis

Zi, Y., Wang, X., Zi, Y., Yu, H., Lan, Y., Fan, Y., Ren, C., Liao, K., & Chen, H. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.03.002 · Cited by 68 · see citing works

Reactive Oxygen Species: From Tumorigenesis to Therapeutic Strategies in Cancer

Attique, I., Haider, Z., Khan, M., Hassan, S., Soliman, M. M., Ibrahim, W. N., & Anjum, S. (2025) · Cancer Medicine · doi:10.1002/cam4.70947 · Cited by 70 · see citing works

GSH and H2O2 dynamic correlation in the ferroptosis pathways revealed by engineered probe in tumor and kidney injury

Wang, Y., Yan, H., Yue, Y., Zhang, Y., Huo, F., Cheng, F., & Yin, C. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.142496 · Cited by 66 · see citing works

Ferroptosis‐Mediated Synergistic Therapy of Hypertrophic Scarring Based on Metal–Organic Framework Microneedle Patch

Zhao, B., Guo, W., Zhou, X., Xue, Y., Wang, T., Li, Q., Tan, L., & Shang, L. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202300575 · Cited by 67 · see citing works

Amplified Fenton-Based Oxidative Stress Utilizing Ultraviolet Upconversion Luminescence-Fueled Nanoreactors for Apoptosis-Strengthened Ferroptosis Anticancer Therapy

Nguyen, N. T., Kim, J., Le, X. T., Lee, W. T., Lee, E. S., Oh, K. T., Choi, H., & Youn, Y. S. (2022) · ACS Nano · doi:10.1021/acsnano.2c08706 · Cited by 65 · see citing works

Tumor Microenvironment‐Activatable Metal‐Phenolic Nanoformulations for Ultrasound‐Boosted Ferroptosis through Triple Regulatory Pathways

Liu, Z., Liu, S., Liu, B., Meng, Q., Yuan, M., Ma, X., Wang, J., Ma, P., & Lin, J. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202407153 · Cited by 65 · see citing works

Mitochondria-Targeting Type I AIE Photosensitizer Combined with H2S Therapy: Uninterrupted Hydroxyl Radical Generation for Enhancing Tumor Therapy

Zhang, T., Liu, Z., Tang, W., Zhu, D., Lyu, M., Lam, J. W. Y., Huang, Q., & Tang, B. Z. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101620 · Cited by 63 · see citing works

Simultaneous Activation of Immunogenic Cell Death and cGAS-STING Pathway by Liver- and Mitochondria-Targeted Gold(I) Complexes for Chemoimmunotherapy of Hepatocellular Carcinoma

Li, F., Wen, Z., Wu, C., Yang, Z., Wang, Z., Diao, W., Chen, D., Xu, Z., Lu, Y., & Liu, W. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c01785 · Cited by 63 · see citing works

Disulfidptosis: a novel cell death modality induced by actin cytoskeleton collapse and a promising target for cancer therapeutics

Li, T., Song, Y., Wei, L., Song, X., & Duan, R. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01871-9 · Cited by 63 · see citing works

Pore-engineered nanoarchitectonics for cancer therapy

Sutrisno, L., & Ariga, K. (2023) · NPG Asia Materials · doi:10.1038/s41427-023-00469-w · Cited by 62 · see citing works

Tumor microenvironment responsive nanozymes for multimodal imaging of tumors

Wang, H., Ouyang, W., & Liu, H. (2024) · Nano TransMed · doi:10.1016/j.ntm.2024.100032 · Cited by 62 · see citing works

HXV2O5 Nanocatalysts Combined with Ultrasound for Triple Amplification of Oxidative Stress to Enhance Cancer Catalytic Therapy

Hou, L., Gong, F., Han, Z., Wang, Y., Yang, Y., Cheng, S., Yang, N., Liu, Z., & Cheng, L. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202208849 · Cited by 61 · see citing works

Mitochondrial carrier 1 (MTCH1) governs ferroptosis by triggering the FoxO1-GPX4 axis-mediated retrograde signaling in cervical cancer cells

Wang, X., Ji, Y., Qi, J., Zhou, S., Wan, S., Chang, F., Gu, Z., An, P., Luo, Y., & Luo, J. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06033-2 · Cited by 61 · see citing works

Ferroptosis: a new hunter of hepatocellular carcinoma

Jiang, Y., Yu, Y., Pan, Z., Glandorff, C., & Sun, M. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01863-1 · Cited by 63 · see citing works

Glutathione-responsive and -exhausting metal nanomedicines for robust synergistic cancer therapy

Liu, P., Hao, L., Liu, M., & Hu, S. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1161472 · Cited by 58 · see citing works

Fe(II)-hydrazide coordinated all-active metal organic framework for photothermally enhanced tumor penetration and ferroptosis-apoptosis synergistic therapy

Xu, W., Wang, T., Qian, J., Wang, J., Hou, G., Wang, Y., Cui, X., Suo, A., & Wu, D. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.135311 · Cited by 59 · see citing works

Boosting ferroptosis via abplatin(iv) for treatment of platinum-resistant recurrent ovarian cancer

Wang, W., Cai, J., Wen, J., Li, X., Yu, Y., Zhang, L., Han, Q., Zheng, W., Ma, Y., Ying, F., et al. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101459 · Cited by 59 · see citing works

Aptamers as Smart Ligands for Targeted Drug Delivery in Cancer Therapy

Wei, Z., Zhou, Y., Wang, R., Wang, J., & Chen, Z. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122561 · Cited by 59 · see citing works

Acidosis activates breast cancer ferroptosis through ZFAND5/SLC3A2 signaling axis and elicits M1 macrophage polarization

Xiong, H., Zhai, Y., Meng, Y., Wu, Z., Qiu, A., Cai, Y., Wang, G., & Yang, L. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216732 · Cited by 59 · see citing works

Advances in research on immunocyte iron metabolism, ferroptosis, and their regulatory roles in autoimmune and autoinflammatory diseases

Zeng, L., Yang, K., Yu, G., Hao, W., Zhu, X., Ge, A., Chen, J., & Sun, L. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06807-2 · Cited by 62 · see citing works

Glutathione Depletion and Stalwart Anticancer Activity of Metallotherapeutics Inducing Programmed Cell Death: Opening a New Window for Cancer Therapy

Roy, N., & Paira, P. (2024) · ACS Omega · doi:10.1021/acsomega.3c08890 · Cited by 60 · see citing works

Type-I Supramolecular Photosensitizer Enables GSH Depletion by Hydrogen Atom Transfer

Lin, Y., Niu, L., Teng, K., & Yang, Q. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c14257 · Cited by 57 · see citing works

DRP1 inhibition-mediated mitochondrial elongation abolishes cancer stemness, enhances glutaminolysis, and drives ferroptosis in oral squamous cell carcinoma

Wang, Z., Tang, S., Cai, L., Wang, Q., Pan, D., Dong, Y., Zhou, H., Li, J., Ji, N., Zeng, X., et al. (2024) · British Journal of Cancer · doi:10.1038/s41416-024-02670-2 · Cited by 57 · see citing works

Cu(II) complex that synergistically potentiates cytotoxicity and an antitumor immune response by targeting cellular redox homeostasis

Huang, K.-B., Wang, F.-Y., Lu, Y., Yang, L.-M., Long, N., Wang, S., Xie, Z., Levine, M. S., Zou, T., Sessler, J. L., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2404668121 · Cited by 58 · see citing works

Light‐Guided Genetic Scissors Based on Phosphorene Quantum Dot

Chen, Z., Huang, H., Deng, J., Meng, C., Zhang, Y., Fan, T., Wang, L., Sun, S., Liu, Y., Lin, H., et al. (2024) · Laser & Photonics Review · doi:10.1002/lpor.202400777 · Cited by 56 · see citing works

Nanotherapeutics induced redox resetting of oxidative and nitrosative stress: targeting glutathione-depletion in cancer

Dangi, K., Kumar, V., Mittal, D., Yadav, P., Malik, M., & Verma, A. K. (2025) · Nanomedicine · doi:10.1080/17435889.2025.2489918 · Cited by 13 · see citing works

Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Xiong, Y., Xiao, C., Li, Z., & Yang, X. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00718h · Cited by 698 · see citing works

Glutathione Depletion and Stalwart Anticancer Activity of Metallotherapeutics Inducing Programmed Cell Death: Opening a New Window for Cancer Therapy

Roy, N., & Paira, P. (2024) · ACS Omega · doi:10.1021/acsomega.3c08890 · Cited by 60 · see citing works

Harnessing ROS Amplification and GSH Depletion Using a Carrier‐Free Nanodrug to Enhance Ferroptosis‐Based Cancer Therapy

Zhang, H., Shan, G., Liu, M., Sun, Q., Yang, T., Peng, R., Li, X., Mei, Y., He, X., & Qiao, L. (2024) · Small · doi:10.1002/smll.202409250 · Cited by 33 · see citing works

Novel strategies of glutathione depletion in photodynamic and chemodynamic therapy: A review

Wolny, D., Stojko, M., & Zajdel, A. (2024) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/191025 · Cited by 9 · see citing works