The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Real‐Time In Vivo Hepatotoxicity Monitoring through Chromophore‐Conjugated Photon‐Upconverting Nanoprobes
Abstract
Drug toxicity is a long‐standing concern of modern medicine. A typical anti‐pain/fever drug paracetamol often causes hepatotoxicity due to peroxynitrite ONOO−. Conventional blood tests fail to offer real‐time unambiguous visualization of such hepatotoxicity in vivo. Here we report a luminescent approach to evaluate acute hepatotoxicity in vivo by chromophore‐conjugated upconversion nanoparticles. Upon injection, these nanoprobes mainly accumulate in the liver and the luminescence of nanoparticles remains suppressed owing to energy transfer to the chromophore. ONOO− can readily bleach the chromophore and thus recover the luminescence, the presence of ONOO− in the liver leads to fast restoring of the near‐infrared emission. Taking advantages of the high tissue‐penetration capability of near‐infrared excitation/emission, these nanoprobes achieve real‐time monitoring of hepatotoxicity in living animals, thereby providing a convenient screening strategy for assessing hepatotoxicity of synthetic drugs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Paracetamol: New Vistas of an Old Drug
Bertolini, A., Ferrari, A., Ottani, A., Guerzoni, S., Tacchi, R., & Leone, S. (2006) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2006.00250.x · Cited by 674
Cited by
Rare-Earth Doping in Nanostructured Inorganic Materials
Zheng, B., Fan, J., Chen, B., Qin, X., Wang, J., Wang, F., Deng, R., & Liu, X. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00644 · Cited by 1,204
Self-citationFunctionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier
Zha, S., Liu, H., Li, H., Li, H., Wong, K.-L., & All, A. H. (2024) · ACS Nano · doi:10.1021/acsnano.3c10674 · Cited by 378
Self-citationActivity‐Based NIR Enzyme Fluorescent Probes for the Diagnosis of Tumors and Image‐Guided Surgery
Li, H., Kim, D., Yao, Q., Ge, H., Chung, J., Fan, J., Wang, J., Peng, X., & Yoon, J. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202009796 · Cited by 363
Upconversion Luminescence-Activated DNA Nanodevice for ATP Sensing in Living Cells
Zhao, J., Gao, J., Xue, W., Di, Z., Xing, H., Lu, Y., & Li, L. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b11161 · Cited by 361
Cheng, D., Peng, J., Lv, Y., Su, D., Liu, D., Chen, M., Yuan, L., & Zhang, X. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b01374 · Cited by 308
Self-citation
Metadata
- Authors
- Peng, J., Samanta, A., Zeng, X., Han, S., Wang, L., Su, D., Loong, D. T. B., Kang, N., Park, S., All, A. H., Jiang, W., Yuan, L., Liu, X., & Chang, Y.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2017-03-15
- Volume
- 56
- Issue
- 15
- Pages
- 4165-4169
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2603197431
- Cited by
- 216
- References
- 1
- FWCI
- 11.74
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Real‐Time In Vivo Hepatotoxicity Monitoring through Chromophore‐Conjugated Photon‐Upconverting Nanoprobes. https://app.cochat.ai/papers/10.1002/anie.201612020
- The paper
- Peng, J., Samanta, A., Zeng, X., Han, S., Wang, L., Su, D., Loong, D. T. B., Kang, N., Park, S., All, A. H., Jiang, W., Yuan, L., Liu, X., & Chang, Y. (2017). Real‐Time In Vivo Hepatotoxicity Monitoring through Chromophore‐Conjugated Photon‐Upconverting Nanoprobes. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201612020
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
