Dynamic Cooperative Glycan Assembly Blocks the Binding of Bacterial Lectins to Epithelial Cells
Open accessAbstract
Pathogens frequently rely on lectins for adhesion and cellular entry into the host. Since these interactions typically result from multimeric binding of lectins to cell‐surface glycans, novel therapeutic strategies are being developed with the use of glycomimetics as competitors of such interactions. Herein we study the benefit of nucleic acid based oligomeric assemblies with PNA–fucose conjugates. We demonstrate that the interactions of a lectin with epithelial cells can be inhibited with conjugates that do not form stable assemblies in solution but benefit from cooperativity between ligand–protein interactions and PNA hybridization to achieve high affinity. A dynamic dimeric assembly fully blocked the binding of the fucose‐binding lectin BambL of Burkholderia ambifaria, a pathogenic bacterium, to epithelial cells with an efficiency of more than 700‐fold compared to l‐fucose.
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The dissociation constant (KD) of 4-mer PNA is in the 3-15 μM range with dissociation speed (koff ∼ 0.3-1.5 s-1).
“Previous studies38 indicated that the dissociation constant (KD) of 4-mer PNA is in the 3–15 μM range with dissociation speed (koff ∼ 0.3–1.5 s–1).”
From Sequencing of <scp>d</scp>/<scp>l</scp>-DNA and XNA by Templated-Synthesis (2025) · cites this paper as [38]
The Results and Discussion section reports KD values of 13 and 3.8 μM for two self-complementary 4-mer PNA sequences, supporting the stated 3–15 μM range. It does not report a koff of 0.3–1.5 s⁻¹ for those duplexes; the off-rates it gives are for a fucose adduct and a lectin-bound assembly. (LLM, conf=0.88)
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Self-citation
- Authors
- Machida, T., Novoa, A., Gillon, É., Zheng, S., Claudinon, J., Eierhoff, T., Imberty, A., Römer, W., & Winssinger, N.
- Affiliations
- University of Geneva (CH)
- Centre National de la Recherche Scientifique (FR)
- University of Freiburg (DE)
- Corresponding author
- Imberty, Anne
- Römer, Winfried
- Winssinger, Nicolas
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2017-05-15
- Volume
- 56
- Issue
- 24
- Pages
- 6762-6766
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2616622385
- Cited by
- 45
- References
- 30
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 8 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 5
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (acceptedVersion, other-oa)
- HAL (submittedVersion, other-oa)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Agence Nationale de la Recherche (ANR-11-LABX-0003-01, SYNB-0002-02)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- European Research Council (ERC-2011-StG 282105)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- carbohydrate mimetics, peptide nucleic acid, cooperative binding, lectin binding inhibition, fucose-binding lectin, bacterial adhesion, epithelial cells
- MeSH terms
- Bacterial Proteins, Epithelial Cells, Humans, Polysaccharides, Protein Binding, Burkholderia, Peptide Nucleic Acids, Biomimetics, Lectins, Ralstonia solanacearum, Cell Line, Tumor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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