The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Near‐Infrared Photothermally Activated DNAzyme–Gold Nanoshells for Imaging Metal Ions in Living Cells
Open accessAbstract
DNAzymes have enjoyed success as metal ion sensors outside cells. Their susceptibility to metal‐dependent cleavage during delivery into cells has limited their intracellular applications. To overcome this limitation, a near‐infrared (NIR) photothermal activation method is presented for controlling DNAzyme activity in living cells. The system consists of a three‐stranded DNAzyme precursor (TSDP), the hybridization of which prevents the DNAzyme from being active. After conjugating the TSDP onto gold nanoshells and upon NIR illumination, the increased temperature dehybridizes the TSDP to release the active DNAzyme, which then carries out metal‐ion‐dependent cleavage, resulting in releasing the cleaved product containing a fluorophore. Using this construct, detecting Zn 2+ in living HeLa cells is demonstrated. This method has expanded the DNAzyme versatility for detecting metal ions in biological systems under NIR light that exhibits lower phototoxicity and higher tissue penetration ability.
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A clearer vision for in vivo imaging
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Femtomolar Sensitivity of Metalloregulatory Proteins Controlling Zinc Homeostasis
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Biostable L-DNAzyme for Sensing of Metal Ions in Biological Systems
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Cited by
McConnell, E. M., Cozma, I., Mou, Q., Brennan, J. D., Lu, Y., & Li, Y. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00240f · Cited by 477
Self-citationUpconversion Luminescence-Activated DNA Nanodevice for ATP Sensing in Living Cells
Zhao, J., Gao, J., Xue, W., Di, Z., Xing, H., Lu, Y., & Li, L. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b11161 · Cited by 361
Self-citationZhao, J., Chu, H., Zhao, Y., Lu, Y., & Li, L. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b01931 · Cited by 287
Self-citationLake, R. J., Yang, Z., Zhang, J., & Lu, Y. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00419 · Cited by 281
Self-citationFluorescent probes for the detection of disease-associated biomarkers
Dou, W.-T., Han, H.-H., Sedgwick, A. C., Zhu, G.-B., Zang, Y., Yang, X.-R., Yoon, J., James, T. D., Li, J., & He, X.-P. (2022) · Science Bulletin · doi:10.1016/j.scib.2022.01.014 · Cited by 266
Metadata
- Authors
- Wang, W., Satyavolu, N. S. R., Wu, Z., Zhang, J., Zhu, J., & Lu, Y.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2017-05-04
- Volume
- 56
- Issue
- 24
- Pages
- 6798-6802
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2611664377
- Cited by
- 202
- References
- 5
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- green
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