Biostable L-DNAzyme for Sensing of Metal Ions in Biological Systems
Open accessAbstract
DNAzymes, an important type of metal ion-dependent functional nucleic acid, are widely applied in bioanalysis and biomedicine. However, the use of DNAzymes in practical applications has been impeded by the intrinsic drawbacks of natural nucleic acids, such as interferences from nuclease digestion and protein binding, as well as undesired intermolecular interactions with other nucleic acids. On the basis of reciprocal chiral substrate specificity, the enantiomer of D-DNAzyme, L-DNAzyme, could initiate catalytic cleavage activity with the same achiral metal ion as a cofactor. Meanwhile, by using the advantage of nonbiological L-DNAzyme, which is not subject to the interferences of biological matrixes, as recognition units, a facile and stable L-DNAzyme sensor was proposed for sensing metal ions in complex biological samples and live cells.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several groups have successfully used l-DNA and l-RNA biosensors in living cells.
“Towards this goal, several groups have successfully employed l-DNA and l-RNA-based biosensors in living cells, supporting the viability of the mirror-image approach.10–13”
From Direct Comparison of <scp>d</scp>-DNA and <scp>l</scp>-DNA Strand-Displacement Reactions in Living Mammalian Cells (2021) · cites this paper as [12]
The Results and Discussion section, “Application of L-DNAzymes for Intracellular Metal Ion Imaging” (page not provided), reports an L-DNAzyme biosensor detecting Cu2+ in cultured HeLa cells. This supports one example of a mirror-image biosensor used in living cells, but this paper does not establish the claim about L-RNA biosensors or several groups. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Functional Nucleic Acid Sensors
Liu, J., Cao, Z. C., & Lu, Y. (2009) · Chemical Reviews · doi:10.1021/cr030183i · Cited by 2,188 · see citing works
Breaker, R. R., & Joyce, G. F. (1994) · Chemistry & Biology · doi:10.1016/1074-5521(94)90014-0 · Cited by 1,479 · see citing works
In Vitro Selection of Functional Nucleic Acids
Wilson, D. S., & Szostak, J. W. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.611 · Cited by 1,209 · see citing works
Liu, J., & Lu, Y. (2007) · Journal of the American Chemical Society · doi:10.1021/ja0717358 · Cited by 647 · see citing works
A DNAzyme-Gold Nanoparticle Probe for Uranyl Ion in Living Cells
Wu, P., Hwang, K., Lan, T., & Lu, Y. (2013) · Journal of the American Chemical Society · doi:10.1021/ja400150v · Cited by 428 · see citing works
Milton, R. C. D., Milton, S. C. F., & Kent, S. B. H. (1992) · Science · doi:10.1126/science.1604320 · Cited by 427 · see citing works
The Origin of Biological Homochirality
Blackmond, D. G. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002147 · Cited by 408 · see citing works
Mirror-image RNA that binds D-adenosine
Klußmann, S., Nolte, A., Bald, R., Erdmann, V. A., & Fürste, J. P. (1996) · Nature Biotechnology · doi:10.1038/nbt0996-1112 · Cited by 397 · see citing works
Liang, H., Zhang, X., Lv, Y., Gong, L., Wang, R., Zhu, X., Yang, R., & Tan, W. (2014) · Accounts of Chemical Research · doi:10.1021/ar500078f · Cited by 359 · see citing works
Self-citationBreaker, R. R. (1997) · Nature Biotechnology · doi:10.1038/nbt0597-427 · Cited by 344 · see citing works
Wu, C. S., Cansız, S., Zhang, L., Teng, I., Qiu, L., Li, J., Liu, Y., Zhou, C., Hu, R., Zhang, T., et al. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b00542 · Cited by 333 · see citing works
Self-citationA highly selective lead sensor based on a classic lead DNAzyme
Lan, T., Furuya, K., & Lu, Y. (2010) · Chemical Communications · doi:10.1039/b926910j · Cited by 281 · see citing works
Bada, J. L. (1995) · Nature · doi:10.1038/374594a0 · Cited by 267 · see citing works
Carmi, N., Balkhi, S. R., & Breaker, R. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2233 · Cited by 262 · see citing works
In Vitro Selection of Catalytic Polynucleotides
Breaker, R. R. (1997) · Chemical Reviews · doi:10.1021/cr960008k · Cited by 239 · see citing works
Bioactive and nuclease-resistant l -DNA ligand of vasopressin
Williams, K. P., Liu, X., Schumacher, T. N., Lin, H. Y.-F., Ausiello, D. A., Kim, P. S., & Bartel, D. P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11285 · Cited by 222 · see citing works
Santiago, F. S., Lowe, H. C., Kavurma, M. M., Chesterman, C. N., Baker, A., Atkins, D. G., & Khachigian, L. M. (1999) · Nature Medicine · doi:10.1038/71020 · Cited by 219 · see citing works
Photocaged DNAzymes as a General Method for Sensing Metal Ions in Living Cells
Hwang, K., Wu, P., Kim, T., Lei, L., Tian, S., Wang, Y., & Lu, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201408333 · Cited by 213 · see citing works
Santiago, F. S., Lowe, H. C., Kavurma, M. M., Chesterman, C. N., Baker, A., Atkins, D. G., & Khachigian, L. M. (1999) · Nature Medicine · doi:10.1038/15215 · Cited by 210 · see citing works
Mirror-design of L-oligonucleotide ligands binding to L-arginine
Nolte, A., Klußmann, S., Bald, R., Erdmann, V. A., & Fürste, J. P. (1996) · Nature Biotechnology · doi:10.1038/nbt0996-1116 · Cited by 206 · see citing works
Translating Bacterial Detection by DNAzymes into a Litmus Test
Tram, K., Kanda, P., Salena, B. J., Huan, S., & Li, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201407021 · Cited by 204 · see citing works
Ke, G., Wang, C., Ge, Y., Zheng, N., Zhu, Z., & Yang, C. J. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3082439 · Cited by 196 · see citing works
Self-citationSmart Mesoporous SiO2 Nanoparticles for the DNAzyme-Induced Multiplexed Release of Substrates
Zhang, Z., Balogh, D., Wang, F., & Willner, I. (2013) · Journal of the American Chemical Society · doi:10.1021/ja311385y · Cited by 190 · see citing works
An Efficient RNA-Cleaving DNA Enzyme that Synchronizes Catalysis with Fluorescence Signaling
Mei, S. H. J., Liu, Z., Brennan, J. D., & Li, Y. (2002) · Journal of the American Chemical Society · doi:10.1021/ja0281232 · Cited by 189 · see citing works
A cross-chiral RNA polymerase ribozyme
Sczepanski, J. T., & Joyce, G. F. (2014) · Nature · doi:10.1038/nature13900 · Cited by 186 · see citing works
Meng, H., Zhang, X., Lv, Y., Zhao, Z., Wang, N., Fu, T., Fan, H., Liang, H., Qiu, L., Zhu, G., et al. (2014) · ACS Nano · doi:10.1021/nn5015962 · Cited by 170 · see citing works
Self-citationSimultaneous Imaging of Zn2+ and Cu2+ in Living Cells Based on DNAzyme Modified Gold Nanoparticle
Li, L., Feng, J., Fan, Y., & Tang, B. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b00204 · Cited by 151 · see citing works
DNA as Sensors and Imaging Agents for Metal Ions
Xiang, Y., & Lu, Y. (2013) · Inorganic Chemistry · doi:10.1021/ic4019103 · Cited by 151 · see citing works
DNAzyme technology and cancer therapy: cleave and let die
Dass, C. R., Choong, P., & Khachigian, L. M. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0510 · Cited by 145 · see citing works
Characterization of a DNA-Cleaving deoxyribozyme
Carmi, N., & Breaker, R. R. (2001) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(01)00035-9 · Cited by 116 · see citing works
Oberthüer, D., Achenbach, J., Gabdulkhakov, A. G., Buchner, K., Maasch, C., Falke, S., Rehders, D., Klußmann, S., & Betzel, C. (2015) · Nature Communications · doi:10.1038/ncomms7923 · Cited by 102 · see citing works
Superior structure stability and selectivity of hairpin nucleic acid probes with an L-DNA stem
Kim, Y., Yang, C. J., & Tan, W. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm771 · Cited by 97 · see citing works
Self-citationDetection of Undegraded Oligonucleotides in Vivo by Fluorescence Resonance Energy Transfer
Uchiyama, H., Hirano, K.-I., Kashiwasake-Jibu, M., & Taira, K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.1.380 · Cited by 95 · see citing works
Hauser, N. C., Martinez, R., Jacob, A., Rupp, S., Hoheisel, J. D., & Matysiak, S. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl671 · Cited by 92 · see citing works
Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer
Yatime, L., Maasch, C., Hoehlig, K., Klußmann, S., Andersen, G. R., & Vater, A. (2015) · Nature Communications · doi:10.1038/ncomms7481 · Cited by 88 · see citing works
Binding of a Structured d -RNA Molecule by an l -RNA Aptamer
Sczepanski, J. T., & Joyce, G. F. (2013) · Journal of the American Chemical Society · doi:10.1021/ja406634g · Cited by 84 · see citing works
Mirror Image DNA Nanostructures for Chiral Supramolecular Assemblies
Lin, C., Ke, Y., Li, Z., Wang, J. H., Liu, Y., & Yan, H. (2008) · Nano Letters · doi:10.1021/nl803328v · Cited by 76 · see citing works
A DNA Spiegelmer to staphylococcal enterotoxin B
Purschke, W. G. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg413 · Cited by 76 · see citing works
Visualization of Single Multivalent Receptor–Ligand Complexes by Transmission Electron Microscopy
Gestwicki, J. E., Strong, L. E., & Kiessling, L. L. (2000) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20001215)39:24 · Cited by 64 · see citing works
DNAzyme Hybridization, Cleavage, Degradation, and Sensing in Undiluted Human Blood Serum
Zhou, W., Chen, Q., Huang, P. J., Ding, J., & Liu, J. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b00220 · Cited by 63 · see citing works
Kim, K., Lee, T., Kim, B., & Ahn, D. (2014) · Chemical Science · doi:10.1039/c3sc52601a · Cited by 59 · see citing works
An l -RNA-based aquaretic agent that inhibits vasopressin in vivo
Purschke, W. G., Eulberg, D., Buchner, K., Vonhoff, S., & Klußmann, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509663103 · Cited by 57 · see citing works
Translating Bacterial Detection by DNAzymes into a Litmus Test
Tram, K., Kanda, P., Salena, B. J., Huan, S., & Li, Y. (2014) · Angewandte Chemie · doi:10.1002/ange.201407021 · Cited by 57 · see citing works
Shen, Q., Zhou, L., Yuan, Y., Huang, Y., Xiang, B., Chen, C., Nie, Z., & Yao, S. (2013) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2013.12.019 · Cited by 51 · see citing works
Li, H., Zhang, Q., Cai, Y., Kong, D., & Shen, H. (2012) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2012.01.037 · Cited by 43 · see citing works
Ligand-Dependent Exponential Amplification of a Self-Replicating l -RNA Enzyme
Olea, C., Horning, D. P., & Joyce, G. F. (2012) · Journal of the American Chemical Society · doi:10.1021/ja302197x · Cited by 39 · see citing works
Li, H., Huang, X., Kong, D., Shen, H., & Liu, Y. (2012) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2012.10.070 · Cited by 38 · see citing works
Hoehlig, K., Bethge, L., & Klussmann, S. (2015) · PLOS ONE · doi:10.1371/journal.pone.0115328 · Cited by 35 · see citing works
Hairpin DNAzymes: a new tool for efficient cellular gene silencing
Abdelgany, A., Wood, M. J. A., & Beeson, D. (2007) · The Journal of Gene Medicine · doi:10.1002/jgm.1061 · Cited by 33 · see citing works
Wyszko, E., Szymański, M., Zeichhardt, H., Müller, F., Barciszewski, J., & Erdmann, V. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054741 · Cited by 19 · see citing works
Negi, S., Dhanasekaran, M., Hirata, T., Urata, H., & Sugiura, Y. (2006) · Chirality · doi:10.1002/chir.20247 · Cited by 14 · see citing works
- Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Zhou, W., Saran, R., & Liu, J. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00063 · Cited by 934 · see citing works
McConnell, E. M., Cozma, I., Mou, Q., Brennan, J. D., Lu, Y., & Li, Y. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00240f · Cited by 482 · see citing works
Röthlisberger, P., & Hollenstein, M. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.04.007 · Cited by 415 · see citing works
Wang, J., Gu, X., Zhang, P., Huang, X., Zheng, X., Chen, M., Feng, H., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b10150 · Cited by 284 · see citing works
Zhou, W., Ding, J., & Liu, J. (2017) · Theranostics · doi:10.7150/thno.17736 · Cited by 252 · see citing works
Wang, W., Satyavolu, N. S. R., Wu, Z., Zhang, J., Zhu, J., & Lu, Y. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201701325 · Cited by 202 · see citing works
Gao, Y., Zhang, S., Wu, C., Li, Q., Shen, Z., Lu, Y., & Wu, Z. (2021) · ACS Nano · doi:10.1021/acsnano.1c04260 · Cited by 191 · see citing works
Self-citationNucleic‐Acid Structures as Intracellular Probes for Live Cells
Samanta, D., Ebrahimi, S. B., & Mirkin, C. A. (2019) · Advanced Materials · doi:10.1002/adma.201901743 · Cited by 154 · see citing works
DNAzyme sensors for detection of metal ions in the environment and imaging them in living cells
McGhee, C. E., Loh, K. Y., & Lu, Y. (2017) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2017.03.002 · Cited by 147 · see citing works
Gao, R., Xu, L., Hao, C., Xu, C., & Kuang, H. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201814282 · Cited by 110 · see citing works
Fu, X., Ke, G., Peng, F., Hu, X., Li, J., Shi, Y., Kong, G., Zhang, X., & Tan, W. (2020) · Nature Communications · doi:10.1038/s41467-020-15297-7 · Cited by 110 · see citing works
Self-citationMirror‐Image Oligonucleotides: History and Emerging Applications
Young, B. E., Kundu, N., & Sczepanski, J. T. (2019) · Chemistry – A European Journal · doi:10.1002/chem.201900149 · Cited by 93 · see citing works
DNAzyme Based Nanomachine for in Situ Detection of MicroRNA in Living Cells
Liu, J., Cui, M.-R., Zhou, H., & Yang, W. R. (2017) · ACS Sensors · doi:10.1021/acssensors.7b00710 · Cited by 84 · see citing works
Li, F., Wang, C., & Guo, W. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201705876 · Cited by 79 · see citing works
Hwang, K., Mou, Q., Lake, R. J., Xiong, M., Holland, B., & Lu, Y. (2019) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.9b01280 · Cited by 77 · see citing works
DNAzymes as key components of biosensing systems for the detection of biological targets
Cozma, I., McConnell, E. M., Brennan, J. D., & Li, Y. (2021) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2021.112972 · Cited by 70 · see citing works
Visually multiplexed quantitation of heavy metal ions in water using volumetric bar-chart chip
Liu, X., Wang, Y., & Song, Y. (2018) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2018.06.046 · Cited by 61 · see citing works
Metal ion detection using functional nucleic acids and nanomaterials
Huang, J., Su, X., & Li, Z. (2017) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2017.04.032 · Cited by 58 · see citing works
Functional nucleic acid-based fluorescent probes for metal ion detection
Xu, J., Jiang, R., Feng, Y., Liu, Z., Huang, J. L., Ma, C., & Wang, K. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214453 · Cited by 56 · see citing works
Functional nucleic acids for cancer theranostics
Peng, T., Deng, Z., He, J., Li, Y., Tan, Y. H., Peng, Y., Wang, X., & Tan, W. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2019.213080 · Cited by 56 · see citing works
Self-citationHeterochiral DNA Strand-Displacement Circuits
Kabza, A. M., Young, B. E., & Sczepanski, J. T. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b10038 · Cited by 55 · see citing works
Shaver, A., Kundu, N., Young, B. E., Vieira, P. A., Sczepanski, J. T., & Arroyo‐Currás, N. (2021) · Langmuir · doi:10.1021/acs.langmuir.1c00166 · Cited by 55 · see citing works
Han, G., Jia, Z., Zhu, Y., Jiao, J., Kong, D., & Feng, X. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b02871 · Cited by 55 · see citing works
Xue, S., Jing, P., & Xu, W. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.07.111 · Cited by 51 · see citing works
Tetrahedral DNA frameworks for biosensing and imaging analysis in living cells
Qi, Z., Wei, C., Zhang, F., Wang, Z., & Zuo, X. (2023) · Nano Today · doi:10.1016/j.nantod.2023.102127 · Cited by 49 · see citing works
In vitro Selection of Chemically Modified DNAzymes
Huang, P. J., & Liu, J. (2020) · ChemistryOpen · doi:10.1002/open.202000134 · Cited by 48 · see citing works
Pure DNA scaffolded drug delivery systems for cancer therapy
Aliouat, H., Peng, Y., Waseem, Z., Wang, S., & Zhou, W. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121532 · Cited by 37 · see citing works
Functional nucleic acids as in vivo metabolite and ion biosensors
Alsaafin, A., & McKeague, M. (2017) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2017.02.030 · Cited by 38 · see citing works
Luo, X., Chen, Z., Li, H., Li, W., Cui, L., & Huang, J. (2019) · The Analyst · doi:10.1039/c9an00332k · Cited by 36 · see citing works
Self-citationChen, J., Chen, S., & Li, F. (2017) · Chemical Communications · doi:10.1039/c7cc04083k · Cited by 35 · see citing works
Wang, W., Satyavolu, N. S. R., Wu, Z., Zhang, J., Zhu, J., & Lu, Y. (2017) · Angewandte Chemie · doi:10.1002/ange.201701325 · Cited by 34 · see citing works
Gao, R., Xu, L., Hao, C., Xu, C., & Kuang, H. (2019) · Angewandte Chemie · doi:10.1002/ange.201814282 · Cited by 33 · see citing works
A carbon nanoparticle and DNase I-Assisted amplified fluorescent biosensor for miRNA analysis
Li, H., Li, Y., Li, W., Cui, L., Huang, G., & Huang, J. (2020) · Talanta · doi:10.1016/j.talanta.2020.120816 · Cited by 30 · see citing works
Self-citationMolecular bioengineering of functional nucleic acids
Du, Z., Wu, X., Dang, Y., Wu, Q., Fu, T., He, L., Wang, X., Mou, S., Fang, X., Qu, F., et al. (2025) · Nature Reviews Bioengineering · doi:10.1038/s44222-025-00361-y · Cited by 31 · see citing works
Self-citationDesigning a biostable L-DNAzyme for lead( <scp>ii</scp> ) ion detection in practical samples
Liang, H., Xie, S., Cui, L., Wu, C., & Zhang, X. (2016) · Analytical Methods · doi:10.1039/c6ay01791f · Cited by 24 · see citing works
Self-citationZhong, W., & Sczepanski, J. T. (2021) · ACS Synthetic Biology · doi:10.1021/acssynbio.0c00527 · Cited by 23 · see citing works
Xing, S., Lin, Y., Cai, L., Basa, P. N., Shigemoto, A. K., Zheng, C., Zhang, F., Burdette, S. C., & Lu, Y. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c00140 · Cited by 23 · see citing works
Functional Zeolitic Imidazolate Framework for Robust l ‐Deoxyribozyme‐Based Therapy
Tan, K., Zhang, Q., Wang, Q., Gong, X. Q., Yu, S., Li, R., Liu, X., & Wang, F. (2022) · Small · doi:10.1002/smll.202204858 · Cited by 23 · see citing works
Chiral Interaction Is a Decisive Factor To Replace d -DNA with l -DNA Aptamers
Feng, X., Cui, Y., Zhang, J., Tang, A., Mao, H., & Kong, D. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b05676 · Cited by 21 · see citing works
Li, B., Liu, J., & Zhou, H. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2017.12.041 · Cited by 20 · see citing works
Through the looking glass: milestones on the road towards mirroring life
Rohden, F., Hoheisel, J. D., & Wieden, H.-J. (2021) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2021.06.006 · Cited by 18 · see citing works
Chen, H., Xie, S., Liang, H., Wu, C. S., Cui, L., Huan, S., & Zhang, X. (2016) · Talanta · doi:10.1016/j.talanta.2016.11.001 · Cited by 16 · see citing works
Self-citationSchaudy, E., Somoza, M. M., & Lietard, J. (2020) · Chemistry - A European Journal · doi:10.1002/chem.202001871 · Cited by 15 · see citing works
Yu, C., & Sczepanski, J. T. (2022) · Chemical Science · doi:10.1039/d2sc05511b · Cited by 14 · see citing works
Mirror-image aptamer kissing complex for arginine-vasopressin sensing
Chovelon, B., Fiore, E., Faure, P., Peyrin, É., & Ravelet, C. (2017) · Analytica Chimica Acta · doi:10.1016/j.aca.2017.11.043 · Cited by 14 · see citing works
Lewis, W. C., Farrell, A., Pradhan, S., & Lu, Y. (2025) · Chemical & Biomedical Imaging · doi:10.1021/cbmi.4c00090 · Cited by 13 · see citing works
Lai, Z., Jin, D., Tian, Y., Chen, X., Han, D., Chen, H., Wang, J., & Yang, Y. (2024) · Advanced Science · doi:10.1002/advs.202410642 · Cited by 13 · see citing works
Self-citationDNA nanostructure-based fluorescent probes for cellular sensing
Kong, G., Zhang, M., Xiong, M., Fu, X., Ke, G., & Zhang, X. (2020) · Analytical Methods · doi:10.1039/d0ay00105h · Cited by 13 · see citing works
Self-citationThe clinical potential of l -oligonucleotides: challenges and opportunities
Shearer, V., Yu, C., Han, X., & Sczepanski, J. T. (2024) · Chemical Science · doi:10.1039/d4sc05157b · Cited by 14 · see citing works
Li, Z., Zhao, J., Wang, Z., & Dai, Z. H. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2017.12.040 · Cited by 12 · see citing works
Heterochiral DNA Strand-Displacement Based on Chimeric d/l -Oligonucleotides
Young, B. E., & Sczepanski, J. T. (2019) · ACS Synthetic Biology · doi:10.1021/acssynbio.9b00335 · Cited by 12 · see citing works
Nonbiodegradable Spiegelmer-Driven Colorimetric Biosensor for Bisphenol A Detection
Ren, S., Cho, S., Lin, R., Gedi, V., Park, S., Ahn, C. W., Lee, D.-K., Lee, M., Lee, S.-W., & Kim, S. (2022) · Biosensors · doi:10.3390/bios12100864 · Cited by 11 · see citing works
Dantsu, Y., & Zhang, W. (2023) · ChemBioChem · doi:10.1002/cbic.202200764 · Cited by 10 · see citing works
Gong, X., Yu, C., Zhang, Y., Sun, Y., Ye, L., & Li, J. (2019) · RSC Advances · doi:10.1039/c9ra06798a · Cited by 9 · see citing works
Zeng, C., Gao, J., Lou, Y., & Cui, L. (2020) · Talanta · doi:10.1016/j.talanta.2020.121179 · Cited by 9 · see citing works
Self-citationZhang, X., Song, Z., Chao, Q., Li, Q., Kong, R., Fan, G., & Luo, X. (2021) · Chemical Communications · doi:10.1039/d1cc06471a · Cited by 9 · see citing works
Self-citationXu, X., He, P., Du, X., & Guo, W. (2022) · Advanced Sustainable Systems · doi:10.1002/adsu.202100265 · Cited by 9 · see citing works
Xu, Y., Li, Y., Zhou, H., Mei, X., Ye, J., Chen, W., & Kang, Y. (2019) · Analytical Methods · doi:10.1039/c8ay02383b · Cited by 8 · see citing works
A pH-regulated stimuli-responsive strategy for RNA-cleaving DNAzyme
Lu, S., Wang, S., Zhao, J., Sun, J. L., & Yang, X. (2019) · Science China Chemistry · doi:10.1007/s11426-019-9657-0 · Cited by 8 · see citing works
Funai, T., Adachi, N., Aotani, M., Wada, S., & Urata, H. (2019) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257770.2019.1658116 · Cited by 8 · see citing works
Assembly of long l -RNA by native RNA ligation
Yu, C., Kabza, A. M., & Sczepanski, J. T. (2021) · Chemical Communications · doi:10.1039/d1cc04296c · Cited by 7 · see citing works
Zhang, Q. Y., Liang, Y., & Xing, H. (2022) · Chemical Research in Chinese Universities · doi:10.1007/s40242-022-2137-3 · Cited by 7 · see citing works
Nucleic acid-based chiral nanostructures and their biomedical applications
Yu, S., Xie, Y., Jiao, Y., Li, N., & Ding, B. (2025) · Nanoscale Horizons · doi:10.1039/d5nh00140d · Cited by 6 · see citing works
Li, Y., Sun, Y., Ye, J., Pan, F., Peng, B., Li, H., Zhang, M., & Xu, Y. (2020) · Analytical Methods · doi:10.1039/c9ay02024a · Cited by 6 · see citing works
Yu, C., He, X., Acero, R. E. P., Han, X., Wang, Y., & Sczepanski, J. T. (2025) · Chemical Science · doi:10.1039/d5sc00596e · Cited by 5 · see citing works
Peinetti, A. S., Ceretti, H. M., Mizrahi, M., González, G. A., Ramírez, S. A., Requejo, F. G., Montserrat, J. M., & Battaglini, F. (2018) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2018.02.002 · Cited by 5 · see citing works
Heterochiral nucleic acid circuits
Kabza, A. M., Young, B. E., Kundu, N., & Sczepanski, J. T. (2019) · Emerging Topics in Life Sciences · doi:10.1042/etls20190102 · Cited by 4 · see citing works
Chen, L., Xu, Z., Shen, L., Peng, S., Yuan, J., Xu, H. L., Wang, Z., Redshaw, C., & Zhang, Q. (2024) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2024.138783 · Cited by 4 · see citing works
Stasyuk, N. Y., Gayda, G. Z., Zakalskiy, A. E., Zakalska, O. M., Errachid, A., & Gonchar, M. V. (2017) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2017.12.031 · Cited by 4 · see citing works
Zhang, Y., Chen, H., Wu, P., & Yuan, L. (2020) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-020-02556-1 · Cited by 4 · see citing works
Self-citationGuan, L., Zhao, J., Zheng, Y., Li, S., Li, S., Yuan, H., & Li, S. (2026) · Talanta · doi:10.1016/j.talanta.2026.129661 · Cited by 3 · see citing works
An expanded substrate scope for cross-chiral ligation enables efficient synthesis of long l -RNAs
Han, X., & Sczepanski, J. T. (2024) · RSC Chemical Biology · doi:10.1039/d4cb00253a · Cited by 3 · see citing works
Liu, H., Li, Y., Du, S., Wang, C., Li, Y., Cao, R., Shi, W., Liu, S., & He, J. (2023) · Molecules · doi:10.3390/molecules28093942 · Cited by 3 · see citing works
DNAzymes in biological detection and gene therapy
Fan, S., Chen, J., Ji, B., Gao, C., Jiang, K., Liu, Y., & Song, J. (2018) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/n972018-00874 · Cited by 2 · see citing works
L-DNA-Based Melt Analysis Enables Within-Sample Validation of PCR Products
Malofsky, N. A., Nelson, D. J., Pask, M. E., & Haselton, F. R. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c01611 · Cited by 2 · see citing works
A Review Article: Uses of DNA as polyion for cationic sensors
Zаrеh, M. M., Elsheikh, A. M., & Mohamed, S. F. (2023) · Bulletin of Faculty of Science Zagazig University · doi:10.21608/bfszu.2022.163720.1182 · Cited by 1 · see citing works
Diverse Applications of DNAzymes in Computing and Nanotechnology
Lakin, M. R., Stefanović, D., & Stojanović, M. N. (2021) · doi:10.1002/9783527814527.ch25 · Cited by 1 · see citing works
Hasan, S. M. A., & Gartia, M. R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820352-1.00156-5
The Chemical Repertoire of DNA Enzymes
Hollenstein, M. (2021) · doi:10.1002/9783527814527.ch23
Nonbiodegradable Spiegelmer-Driven Colorimetric Biosensor for Bisphenol a DetectionPreprint
Lee, S., Shu, R., Choi, S., Lin, R., Park, S., Ahn, C. W., Lee, D.-K., Lee, M., & Kim, S. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4069169
Left-Handed Helices in DNA Nanotechnology
Selvam, S., Mathivanan, J., & Chandrasekaran, A. R. (2026) · JACS Au · doi:10.1021/jacsau.6c00027
- Authors
- Cui, L., Peng, R., Fu, T., Zhang, X., Wu, C., Chen, H., Liang, H., Yang, C. J., & Tan, W.
- Affiliations
- Hunan University (CN)
- Xiamen University (CN)
- Corresponding author
- Zhang, Xiaobing
- Tan, Weihong
- ORCID
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-12-22
- Volume
- 88
- Issue
- 3
- Pages
- 1850-1855
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- PMC
- PMC4892185
- OpenAlex
- W2216213960
- Semantic Scholar
- 8a5bf3bfd9d3e84eb5ae311518c732ed929927a6
- Cited by
- 81
- References
- 52
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 8 · 2021: 11 · 2020: 10 · 2019: 13 · 2018: 7 · 2017: 13 · 2016: 4
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Analytical Chemistry (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA133086)
- National Institute of General Medical Sciences (GM079359)
- National Natural Science Foundation of China (21221003, 21325520, 21327009, 21405039)
- Ministry of Science and Technology of the People's Republic of China (2011CB911000, 2011YQ03012412)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- DNAzyme, metal ion sensing, biostability, metal cofactors, nucleic acid cleavage, biological specimen, nuclease resistance
- MeSH terms
- Copper, Enzyme Stability, HeLa Cells, Humans, Ions, Lead, Tumor Cells, Cultured, DNA, Catalytic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
