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Poly‐cytosine DNA as a High‐Affinity Ligand for Inorganic Nanomaterials

Lu, Chang, Huang, Zhicheng, Liu, Biwu, Liu, Yibo, Ying, Yibin, Liu, Juewen·2017·Angewandte Chemie International Edition

Abstract

Attaching DNA to nanomaterials is the basis for DNA‐directed assembly, sensing, and drug delivery using such hybrid materials. Poly‐cytosine (poly‐C) DNA is a high affinity ligand for four types of commonly used nanomaterials, including nanocarbons (graphene oxide and single‐walled carbon nanotubes), transition metal dichalcogenides (MoS 2 and WS 2), metal oxides (Fe 3 O 4 and ZnO), and metal nanoparticles (Au and Ag). Compared to other homo‐DNA sequences, poly‐C DNA has the highest affinity for the first three types of materials. Using a diblock DNA containing a poly‐C block to attach to surfaces, the target DNA was successfully hybridized to the other block on graphene oxide more efficiently than that containing a typical poly‐A block, especially in the presence of non‐specific background DNA, proteins, or surfactants. This work provides a simple solution for functionalizing nanomaterials with non‐modified DNA and offers new insights into DNA biointerfaces.

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Metadata

Authors
Lu, C., Huang, Z., Liu, B., Liu, Y., Ying, Y., & Liu, J.
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2017-04-21
Volume
56
Issue
22
Pages
6208-6212
ISSN
  • 1433-7851 (ISSN-L)
  • 1521-3773
OpenAlex
W2605687434
Cited by
159
References
1
FWCI
7.57
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Poly‐cytosine DNA as a High‐Affinity Ligand for Inorganic Nanomaterials. https://app.cochat.ai/papers/10.1002/anie.201702998
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Lu, C., Huang, Z., Liu, B., Liu, Y., Ying, Y., & Liu, J. (2017). Poly‐cytosine DNA as a High‐Affinity Ligand for Inorganic Nanomaterials. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201702998

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