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Poly‐cytosine DNA as a High‐Affinity Ligand for Inorganic Nanomaterials
Abstract
Attaching DNA to nanomaterials is the basis for DNA‐directed assembly, sensing, and drug delivery using such hybrid materials. Poly‐cytosine (poly‐C) DNA is a high affinity ligand for four types of commonly used nanomaterials, including nanocarbons (graphene oxide and single‐walled carbon nanotubes), transition metal dichalcogenides (MoS 2 and WS 2), metal oxides (Fe 3 O 4 and ZnO), and metal nanoparticles (Au and Ag). Compared to other homo‐DNA sequences, poly‐C DNA has the highest affinity for the first three types of materials. Using a diblock DNA containing a poly‐C block to attach to surfaces, the target DNA was successfully hybridized to the other block on graphene oxide more efficiently than that containing a typical poly‐A block, especially in the presence of non‐specific background DNA, proteins, or surfactants. This work provides a simple solution for functionalizing nanomaterials with non‐modified DNA and offers new insights into DNA biointerfaces.
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Nanostructures in Biodiagnostics
Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603
Cited by
DNA Functional Materials Assembled from Branched DNA: Design, Synthesis, and Applications
Dong, Y., Yao, C., Zhu, Y., Yang, L., Luo, D., & Yang, D. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00294 · Cited by 533
Hu, M., Yuan, C., Tian, T., Wang, X., Sun, J., Xiong, E., & Zhou, X. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c00217 · Cited by 267
Metadata
- Authors
- Lu, C., Huang, Z., Liu, B., Liu, Y., Ying, Y., & Liu, J.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2017-04-21
- Volume
- 56
- Issue
- 22
- Pages
- 6208-6212
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2605687434
- Cited by
- 159
- References
- 1
- FWCI
- 7.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lu, C., Huang, Z., Liu, B., Liu, Y., Ying, Y., & Liu, J. (2017). Poly‐cytosine DNA as a High‐Affinity Ligand for Inorganic Nanomaterials. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201702998
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