Cited by 4,603Advanced biosensing and bioanalysis techniquesGold and Silver Nanoparticles Synthesis and ApplicationsNanotechnology research and applications

Nanostructures in Biodiagnostics

Rosi, Nathaniel L., Mirkin, Chad A.·2005·Chemical Reviews

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVArticleNanostructures in BiodiagnosticsNathaniel L. Rosi and Chad A. MirkinView Author Information Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113 Cite this: Chem. Rev. 2005, 105, 4, 1547–1562Publication Date (Web):March 23, 2005Publication History Received23 November 2004Published online23 March 2005Published inissue 1 April 2005https://pubs.acs.org/doi/10.1021/cr030067fhttps://doi.org/10.1021/cr030067fresearch-articleACS PublicationsCopyright © 2005 American Chemical SocietyRequest reuse permissionsArticle Views34466Altmetric-Citations4159LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Assays,Biopolymers,Genetics,Metal nanoparticles,Nanoparticles Get e-Alerts

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Crossref · 10.1021/cr030067f

Cites

134 of 134 references verified0 citation errors · 0 not checkable

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  • The functionalized NPs possess unique advantages over antibody-based platforms: comparable size and diffusion kinetics to proteins, high surface area per volume and high number of flexible binding sites, and inexpensive, simple, fast, scalable synthesis with minimal batch-to-batch variability.

    “These results highlight the unique advantages that these functionalized NPs possess for protein enrichment over antibody-based platforms: (a) comparable size and diffusion kinetics to proteins, promoting effective capture of low-abundance proteins within complex mixtures20,47,48; (b) high surface area per volume and high number of flexible binding sites, contributing to high ligand density and”

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Authors
Rosi, N. L., & Mirkin, C. A.
Affiliations
Northwestern University (US)
Venue
Chemical Reviews
Published
2005-03-23
Volume
105
Issue
4
Pages
1547-1562
ISSN
  • 0009-2665 (ISSN-L)
  • 1520-6890
OpenAlex
W2078820160
Cited by
4,603
References
135
Citations by year
2026: 33 · 2025: 50 · 2024: 84 · 2023: 90 · 2022: 100 · 2021: 129 · 2020: 161 · 2019: 156 · 2018: 180 · 2017: 179 · 2016: 246 · 2015: 299 · 2014: 329 · 2013: 340 · 2012: 419
FWCI
16.87
Type
journal article
Language
en
Open access
closed
Locations
  • Chemical Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Defense Advanced Research Projects Agency
  • Air Force Office of Scientific Research
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
  • Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
  • Physical Sciences › Engineering › Biomedical Engineering › Nanotechnology research and applications
Keywords
nanostructures, biodiagnostics, nanomedicine, metal nanoparticles, biosensors, assay, biopolymers, genetic diagnosis
MeSH terms
Models, Molecular, Surface Properties, Biosensing Techniques, Molecular Diagnostic Techniques, Nanostructures

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