The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Nanoscale Metal–Organic Layers for Deeply Penetrating X‐ray‐Induced Photodynamic Therapy
Open accessAbstract
We report the rational design of metal–organic layers (MOLs) that are built from [Hf 6 O 4(OH)4(HCO 2)6] secondary building units (SBUs) and Ir[bpy(ppy)2]+‐ or [Ru(bpy)3]2+‐derived tricarboxylate ligands (Hf‐BPY‐Ir or Hf‐BPY‐Ru; bpy=2,2′‐bipyridine, ppy=2‐phenylpyridine) and their applications in X‐ray‐induced photodynamic therapy (X‐PDT) of colon cancer. Heavy Hf atoms in the SBUs efficiently absorb X‐rays and transfer energy to Ir[bpy(ppy)2]+ or [Ru(bpy)3]2+ moieties to induce PDT by generating reactive oxygen species (ROS). The ability of X‐rays to penetrate deeply into tissue and efficient ROS diffusion through ultrathin 2D MOLs (ca. 1.2 nm) enable highly effective X‐PDT to afford superb anticancer efficacy.
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Second window for in vivo imaging
Smith, A. M., Mancini, M. C., & Nie, S. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.326 · Cited by 2,848
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Phototherapy in cancer treatment: strategies and challenges
Cai, Y., Chai, T., Nguyen, W., Liu, J., Xiao, E., Ran, X., Ran, Y., Du, D., Chen, W., & Chen, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02140-y · Cited by 453
Nanoscale metal–organic frameworks for phototherapy of cancer
Lan, G., Ni, K., & Lin, W. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.09.007 · Cited by 420
Self-citationWang, C., Cao, F., Ruan, Y., Jia, X., Zhen, W., & Jiang, X. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201903981 · Cited by 411
X-ray-activated nanosystems for theranostic applications
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Metadata
- Authors
- Lan, G., Ni, K., Xu, R., Lu, K., Lin, Z., Chan, C., & Lin, W.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2017-08-25
- Volume
- 56
- Issue
- 40
- Pages
- 12102-12106
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2742204633
- Cited by
- 192
- References
- 1
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Lan, G., Ni, K., Xu, R., Lu, K., Lin, Z., Chan, C., & Lin, W. (2017). Nanoscale Metal–Organic Layers for Deeply Penetrating X‐ray‐Induced Photodynamic Therapy. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201704828
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