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A Glowing Trajectory between Bio‐ and Chemiluminescence: From Luciferin‐Based Probes to Triggerable Dioxetanes
Abstract
Bioluminescent and chemiluminescent probes are widely used for noninvasive imaging applications because of their high sensitivity and the simplicity of the equipment required to perform the measurement. Synthetic luciferin‐analogue probes with in vivo imaging performance better than that of luciferin are now available. In addition, caged luciferin‐based bioluminogenic probes have been emerged as a general tool for the visualization of different enzymes and analytes in vivo. Recent discoveries have led to development of highly efficient chemiluminescent probes that are extremely bright under physiological conditions. As discussed in this Minireview, chemiluminescence is ready to realize its potential as a valuable tool for imaging in living systems.
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A clearer vision for in vivo imaging
Weissleder, R. (2001) · Nature Biotechnology · doi:10.1038/86684 · Cited by 3,839
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Fluorogenic probes for disease-relevant enzymes
Zhang, J., Chai, X., He, X.-P., Kim, H.-J., Yoon, J., & Tian, H. (2019) · Chemical Society Reviews · doi:10.1039/c7cs00907k · Cited by 606
Activity‐Based Sensing: A Synthetic Methods Approach for Selective Molecular Imaging and Beyond
Bruemmer, K. J., Crossley, S. W. M., & Chang, C. J. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201909690 · Cited by 265
Yang, J., Yin, W., Van, R., Yin, K., Wang, P., Zheng, C., Zhu, B., Ran, K., Zhang, C., Kumar, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17783-4 · Cited by 123
Gao, J., Chen, Z., Li, X., Yang, M., Lv, J., Li, H., & Yuan, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012556 · Cited by 61
Metadata
- Authors
- Hananya, N., & Shabat, D.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2017-12-07
- Volume
- 56
- Issue
- 52
- Pages
- 16454-16463
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2774843262
- Cited by
- 191
- References
- 1
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hananya, N., & Shabat, D. (2017). A Glowing Trajectory between Bio‐ and Chemiluminescence: From Luciferin‐Based Probes to Triggerable Dioxetanes. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201706969
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