The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Iron‐Catalyzed Cross‐Couplings in the Synthesis of Pharmaceuticals: In Pursuit of Sustainability
Abstract
The scarcity of precious metals has led to the development of sustainable strategies for metal‐catalyzed cross‐coupling reactions. The establishment of new catalytic methods using iron is attractive owing to the low cost, abundance, ready availability, and very low toxicity of iron. In the last few years, sustainable methods for iron‐catalyzed cross‐couplings have entered the critical area of pharmaceutical research. Most notably, iron is one of the very few metals that have been successfully field‐tested as highly effective base‐metal catalysts in practical, kilogram‐scale industrial cross‐couplings. In this Minireview, we critically discuss the strategic benefits of using iron catalysts as green and sustainable alternatives to precious metals in cross‐coupling applications for the synthesis of pharmaceuticals. The Minireview provides an essential introduction to the fundamental aspects of practical iron catalysis, highlights areas for improvement, and identifies new fields to be explored.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Vitaku, E., Smith, D. T., & Njardarson, J. T. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm501100b · Cited by 6,418
Green Chemistry: Principles and Practice
Anastas, P., & Eghbali, N. (2010) · Chem. Soc. Rev. · doi:10.1039/b918763b · Cited by 5,256
Palladium‐Catalyzed Cross‐Coupling: A Historical Contextual Perspective to the 2010 Nobel Prize
Johansson Seechurn, C. C. C., Kitching, M. O., Colacot, T. J., & Snieckus, V. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201107017 · Cited by 3,007
Ruthenium(II)-Catalyzed C–H Bond Activation and Functionalization
Arockiam, P. B., Bruneau, C., & Dixneuf, P. H. (2012) · Chemical Reviews · doi:10.1021/cr300153j · Cited by 2,743
The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates
Roughley, S. D., & Jordan, A. M. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200187y · Cited by 2,725
Recent advances in homogeneous nickel catalysis
Tasker, S. Z., Standley, E. A., & Jamison, T. F. (2014) · Nature · doi:10.1038/nature13274 · Cited by 2,293
Iron-Catalyzed Reactions in Organic Synthesis
Bolm, C., Legros, J., Le Paih, J., & Zani, L. (2004) · Chemical Reviews · doi:10.1021/cr040664h · Cited by 2,148
Brown, D. G., & Boström, J. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01409 · Cited by 1,964
Magano, J., & Dunetz, J. R. (2011) · Chemical Reviews · doi:10.1021/cr100346g · Cited by 1,860
Iron Catalysis in Organic Synthesis
Bauer, I., & Knölker, H.-J. (2015) · Chemical Reviews · doi:10.1021/cr500425u · Cited by 1,850
Cited by
Palladium-Catalyzed Cross-Coupling Reactions: A Powerful Tool for the Synthesis of Agrochemicals
Devendar, P., Qu, R.-Y., Kang, W.-M., He, B., & Yang, G.-F. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03792 · Cited by 448
Sears, J. D., Muñoz, S. B., Daifuku, S. L., Shaps, A. A., Carpenter, S. H., Brennessel, W. W., & Neidig, M. L. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201813578 · Cited by 50
The Role of Organoferrates in Iron‐Catalyzed Cross‐Couplings
Sandl, S., & Jacobi von Wangelin, A. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201914844 · Cited by 18
Metadata
- Authors
- Piontek, A., Bisz, E., & Szostak, M.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2018-07-17
- Volume
- 57
- Issue
- 35
- Pages
- 11116-11128
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2884412620
- Cited by
- 285
- References
- 91
- FWCI
- 14.76
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Iron‐Catalyzed Cross‐Couplings in the Synthesis of Pharmaceuticals: In Pursuit of Sustainability. https://app.cochat.ai/papers/10.1002/anie.201800364
- The paper
- Piontek, A., Bisz, E., & Szostak, M. (2018). Iron‐Catalyzed Cross‐Couplings in the Synthesis of Pharmaceuticals: In Pursuit of Sustainability. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201800364
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
