Custom‐Made Ceria Nanoparticles Show a Neuroprotective Effect by Modulating Phenotypic Polarization of the Microglia
Abstract
The neuroprotective effect of ceria nanoparticles in the context of brain disorders has been explained by their antioxidant effect. However, the in‐depth mechanism remains unknown. As resident immune cells in the brain, microglia exert a variety of functional reprogramming termed as polarization in response to stress stimuli. Herein, custom‐made ceria nanoparticles were developed and found to scavenge multiple reactive oxygen species with extremely high efficiency. These nanoparticles drove microglial polarization from a pro‐inflammatory phenotype to an anti‐inflammatory phenotype under pathological conditions. Pretreatment of these nanoparticles changed the microglial function from detrimental to protective for the neuronal cells by blocking the pro‐inflammatory signaling. This work not only helps to elucidate the mechanism of ceria‐nanoparticle‐mediated neuroprotection but also provides a new strategy to rebalance the immuno‐environment by switching the equilibrium of the phenotypic activation of microglia.
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Microglia are classified into M1 (classically activated) cells that secrete proinflammatory cytokines and M2 (alternatively activated) cells that promote tissue regeneration and repair.
“Microglia are classified into two subtypes: classically activated (M1) cells, which secrete proinflammatory cytokines, and alternatively activated (M2) cells, which promote tissue regeneration and repair [9–12].”
From Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression (2022) · cites this paper as [10]
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Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression
Xian, X., Cai, L.-L., Li, Y., Wang, R.-C., Xu, Y.-H., Chen, Y.-J., Xie, Y.-H., Zhu, X.-L., & Li, Y.-F. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01332-w · Cited by 169 · see citing works
Versatile nanomaterials for Alzheimer’s disease: Pathogenesis inspired disease-modifying therapy
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- Authors
- Zeng, F., Wu, Y., Li, X., Ge, X., Guo, Q., Lou, X., Cao, Z., Hu, B., Long, N. J., Mao, Y., & Li, C.
- Affiliations
- Key Laboratory of Smart Drug Delivery Ministry of Education School of Pharmacy Fudan University Shanghai 201203 China
- Radiology Department Shanghai Ninth People's Hospital Shanghai Jiao Tong University Shanghai 200011 China
- Shanghai Key Laboratory of Magnetic Resonance School of Physics and Materials Science East China Normal University Shanghai 200062 China
- Department of Chemistry Imperial College London South Kensington London SW7 2AZ UK
- Department of Neurosurgery Huashan Hospital Fudan University Shanghai 200040 China
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2018-04-14
- Volume
- 57
- Issue
- 20
- Pages
- 5808-5812
- ISSN
- 1433-7851
- 1521-3773
- Cited by
- 186
- References
- 4
- Language
- en
- Update notices
- Licence
- Funders
- National Natural Science Foundation of China (81571741, 81771895, 81572483, 81611130223, 21522303)
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