Cited by 27Alzheimer's disease research and treatmentsNanoparticle-Based Drug DeliveryCholinesterase and Neurodegenerative Diseases

Versatile nanomaterials for Alzheimer’s disease: Pathogenesis inspired disease-modifying therapy

Xi, Yilong, Chen, Yun, Jin, Yi, Han, Guochen, Song, Mingjie, Song, Tingting, Shi, Yang, Tao, Ling +4 more·2022·Journal of Controlled Release

Abstract

Current therapeutic strategies for Alzheimer's disease (AD) face the dilemma of no effective drugs that can delay the onset or slow the disease progression. Despite tremendous effort being involved, several anti-AD drugs come into clinical trials but with a moderate-to-poor success rate due to the complex AD pathogenesis and the blood-brain barrier (BBB). Insight into the complex AD pathogenesis is enabling new inspiration that have the potential to help improve our understanding and design of anti-AD nanomedicine. Herein, the complex AD pathogenesis and interaction between different therapeutic targets are summarized and highlighted, and key challenges facing translation of anti-AD nanomedicine from benchtop to bedside are discussed. Following combing through the complex pathogenesis and a contextual overview of clinical status of anti-AD compounds, we discuss the recent advances of exploring versatile nanomaterials in AD treatment from the pathogenesis. The focus here is especially on how to design pathogenesis-inspired nanomaterials for delivering therapeutics cross BBB and modulating the AD pathology by themselves as active ingredients. Collectively, this review highlights the pathogenesis-oriented nanomedicine design and provides with an easily accessible guide to the key opportunities and challenges currently facing the anti-AD nanomedicine.

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Crossref · 10.1016/j.jconrel.2022.02.034

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183 of 183 references verified0 citation errors · 0 not checkable

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  • Some DMTs work to support neurogenesis, which will support cognitive function even as the disease advances.

    “Furthermore, some DMTs work to support neurogenesis, the process that results in the formation of new neurons, which will support cognitive function even as the disease advances [78].”

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Authors
Xi, Y., Chen, Y., Jin, Y., Han, G., Song, M., Song, T., Shi, Y., Tao, L., Huang, Z., Zhou, J., Ding, Y., & Zhang, H.
Affiliations
  • China Pharmaceutical University (CN)
  • Guiyang Medical University (CN)
Corresponding author
  • Zhou, Jianping
  • Ding, Yang
  • Zhang, Huaqing
Venue
Journal of Controlled Release
Publisher
Elsevier BV
Published
2022-05
Volume
345
Pages
38-61
ISSN
0168-3659 (ISSN-L)
OpenAlex
W4214869075
Cited by
27
References
182
Citations by year
2026: 2 · 2025: 6 · 2024: 10 · 2023: 5 · 2022: 4
FWCI
0.86
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Controlled Release (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
Keywords
Alzheimer's disease, nanomedicine, disease-modifying therapy, blood-brain barrier, nanomaterials, Alzheimer's disease pathogenesis, anti-Alzheimer agents, translation to clinical practice
MeSH terms
Alzheimer Disease, Biological Transport, Blood-Brain Barrier, Humans, Nanostructures, Nanomedicine

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