The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Conjugated Polymer Nanoparticles with Appended Photo‐Responsive Units for Controlled Drug Delivery, Release, and Imaging
Abstract
Carriers that can afford tunable physical and structural changes are envisioned to address critical issues in controlled drug delivery applications. Herein, photo‐responsive conjugated polymer nanoparticles (CPNs) functionalized with donor–acceptor Stenhouse adduct (DASA) and folic acid units for controlled drug delivery and imaging are reported. Upon visible‐light (λ=550 nm) irradiation, CPNs simultaneously undergo structure, color, and polarity changes that release encapsulated drugs into the cells. The backbone of CPNs favors FRET to DASA units boosting their fluorescence. Notably, drug‐loaded CPNs exhibit excellent biocompatibility in the dark, indicating perfect control of the light trigger over drug release. Delivery of both hydrophilic and hydrophobic drugs with good loading efficiency was demonstrated. This strategy enables remotely controlled drug delivery with visible‐light irradiation, which sets an example for designing delivery vehicles for non‐invasive therapeutics.
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A review of the optical properties of biological tissues
Cheong, W. F., Prahl, S. A., & Welch, A. J. (1990) · IEEE Journal of Quantum Electronics · doi:10.1109/3.64354 · Cited by 2,530
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Smart Nanomaterials in Cancer Theranostics: Challenges and Opportunities
Kashyap, B. K., Singh, V. V., Solanki, M. K., Kumar, A., Ruokolainen, J., & Kesari, K. K. (2023) · ACS Omega · doi:10.1021/acsomega.2c07840 · Cited by 348
Recent advances in stimuli-responsive polymer systems for remotely controlled drug release
Zhang, A., Jung, K., Li, A., Liu, J., & Boyer, C. (2019) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2019.101164 · Cited by 268
Visible light—responsive drug delivery nanoparticle via donor–acceptor stenhouse adducts (DASA)
Yap, J. E., Zhang, L., Lovegrove, J. T., Beves, J. E., & Stenzel, M. H. (2020) · Macromolecular Rapid Communications · doi:10.1002/marc.202000236 · Cited by 60
Visible‐ and Near‐Infrared Light‐Driven Molecular Photoswitches for Biological Applications
Xu, Y., Tang, Y., & Li, Q. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202416359 · Cited by 49
Zhang, H., Chen, P.-Z., Niu, L.-Y., & Yang, Q.-Z. (2020) · Materials Chemistry Frontiers · doi:10.1039/c9qm00672a · Cited by 36
Metadata
- Authors
- Senthilkumar, T., Zhou, L., Gu, Q., Liu, L., Lv, F., & Wang, S.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2018-09-11
- Volume
- 57
- Issue
- 40
- Pages
- 13114-13119
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2887585241
- Cited by
- 161
- References
- 1
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Senthilkumar, T., Zhou, L., Gu, Q., Liu, L., Lv, F., & Wang, S. (2018). Conjugated Polymer Nanoparticles with Appended Photo‐Responsive Units for Controlled Drug Delivery, Release, and Imaging. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201807158
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