The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Bioinspired Engineering of a Multivalent Aptamer‐Functionalized Nanointerface to Enhance the Capture and Release of Circulating Tumor Cells
Abstract
Circulating tumor cell (CTC)‐enrichment by using aptamers has a number of advantages, but the issue of compromised binding affinities and stabilities in real samples hinders its wide applications. Inspired by the high efficiency of the prey mechanism of the octopus, we engineered a deterministic lateral displacement (DLD)‐patterned microfluidic chip modified with multivalent aptamer‐functionalized nanospheres (AP‐Octopus‐Chip) to enhance capture efficiency. The multivalent aptamer–antigen binding efficiency improves 100‐fold and the capture efficiency is enhanced more than 300 % compared with a monovalent aptamer‐modified chip. Moreover, the captured cancer cells can be released through a thiol exchange reaction with up to 80 % efficiency and 96 % viability, which is fully compatible with downstream mutation detection and CTC culture. Using the chip, we were able to find CTCs in all cancer samples analyzed.
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Cites
Integrating liquid biopsies into the management of cancer
Siravegna, G., Marsoni, S., Siena, S., & Bardelli, A. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.14 · Cited by 1,908
Continuous Particle Separation Through Deterministic Lateral Displacement
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Challenges in circulating tumour cell research
Alix-Panabières, C., & Pantel, K. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3820 · Cited by 1,300
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Circulating and disseminated tumour cells — mechanisms of immune surveillance and escape
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Slanted spiral microfluidics for the ultra-fast, label-free isolation of circulating tumor cells
Warkiani, M. E., Guan, G., Luan, K. B., Lee, W. C., Bhagat, A. A. S., Kant Chaudhuri, P., Tan, D. S.-W., Lim, W. T., Lee, S. C., Chen, P. C. Y., et al. (2014) · Lab Chip · doi:10.1039/c3lc50617g · Cited by 573
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Cited by
Nucleic Acid Aptamers for Molecular Diagnostics and Therapeutics: Advances and Perspectives
Li, L., Xu, S., Yan, H., Li, X., Yazd, H. S., Li, X., Huang, T., Cui, C., Jiang, J., & Tan, W. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202003563 · Cited by 432
Micro/nanofluidic technologies for efficient isolation and detection of circulating tumor cells
Yue, W.-Q., Tan, Z., Li, X.-P., Liu, F.-F., & Wang, C. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.06.009 · Cited by 34
Metadata
- Authors
- Song, Y., Shi, Y., Huang, M., Wang, W., Wang, Y., Cheng, J., Lei, Z., Zhu, Z., & Yang, C.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2019-01-11
- Volume
- 58
- Issue
- 8
- Pages
- 2236-2240
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2905028297
- Cited by
- 266
- References
- 32
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Song, Y., Shi, Y., Huang, M., Wang, W., Wang, Y., Cheng, J., Lei, Z., Zhu, Z., & Yang, C. (2019). Bioinspired Engineering of a Multivalent Aptamer‐Functionalized Nanointerface to Enhance the Capture and Release of Circulating Tumor Cells. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201809337
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