The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Directed Evolution Empowered Redesign of Natural Proteins for the Sustainable Production of Chemicals and Pharmaceuticals
Abstract
Directed evolution has advanced into a standard industrial “tool” to tailor naturally occurring proteins for a variety of biotechnological applications, thus enabling product valorization and bringing societal benefits across industrial sectors. Examples are sustainable enzymatic production processes for chemicals, pharmaceuticals, or applications in the food, feed, and laundry industries. In essence, directed evolution has contributed to sustainable industrial processes that fuel the transition from a fossil‐based economy to a biobased economy utilizing renewable resources. Phage display technologies represent a comparable breakthrough that allow for the directed evolution of binding proteins by physical coupling between a phenotype and the respective genotype, thus enabling the identification of highly selective antibodies for a broad variety of applications in diagnostics and therapy.
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Cites
An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule.
Mills, D. R., Peterson, R. L., & Spiegelman, S. (1967) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.58.1.217 · Cited by 648
Cited by
Directed Evolution: Methodologies and Applications
Wang, Y., Xue, P., Cao, M., Yu, T., Lane, S. T., & Zhao, H. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00260 · Cited by 719
The Hitchhiker's guide to biocatalysis: recent advances in the use of enzymes in organic synthesis
Sheldon, R. A., Brady, D., & Bode, M. L. (2020) · Chemical Science · doi:10.1039/c9sc05746c · Cited by 299
Embracing Nature’s Catalysts: A Viewpoint on the Future of Biocatalysis
Hauer, B. (2020) · ACS Catalysis · doi:10.1021/acscatal.0c01708 · Cited by 284
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Metadata
- Authors
- Bornscheuer, U. T., Hauer, B., Jaeger, K. E., & Schwaneberg, U.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2018-12-06
- Volume
- 58
- Issue
- 1
- Pages
- 36-40
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2902111471
- Cited by
- 227
- References
- 1
- FWCI
- 7.93
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
