The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Restraining Cancer Cells by Dual Metabolic Inhibition with a Mitochondrion‐Targeted Platinum(II) Complex
Abstract
Cancer cells usually adapt metabolic phenotypes to chemotherapeutics. A defensive strategy against this flexibility is to modulate signaling pathways relevant to cancer bioenergetics. A triphenylphosphonium‐modified terpyridine platinum(II) complex (TTP) was designed to inhibit thioredoxin reductase (TrxR) and multiple metabolisms of cancer cells. TTP exhibited enhanced cytotoxicity against cisplatin‐insensitive human ovarian cancer cells in a caspase‐3‐independent manner and showed preferential inhibition to mitochondrial TrxR. The morphology and function of mitochondria were severely damaged, and the levels of mitochondrial and cellular reactive oxygen species were decreased. As a result, TTP exerted strong inhibition to both mitochondrial and glycolytic bioenergetics, thus inducing cancer cells to enter a hypometabolic state.
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Self-citationModulation of oxidative stress as an anticancer strategy
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Cited by
Platinum-based drugs for cancer therapy and anti-tumor strategies
Zhang, C., Xu, C., Gao, X., & Yao, Q. (2022) · Theranostics · doi:10.7150/thno.69424 · Cited by 1,018
Mitochondria targeted fluorogenic theranostic agents for cancer therapy
Singh, H., Sareen, D., George, J. M., Bhardwaj, V., Rha, H., Lee, S. J., Sharma, S., Sharma, A., & Kim, J. S. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.214283 · Cited by 72
Metadata
- Authors
- Wang, K., Zhu, C., He, Y., Zhang, Z., Zhou, W., Muhammad, N., Guo, Y., Wang, X., & Guo, Z.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2019-02-27
- Volume
- 58
- Issue
- 14
- Pages
- 4638-4643
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2914465892
- Cited by
- 171
- References
- 7
- FWCI
- 8.43
- Type
- journal article
- Language
- en
- Open access
- closed
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