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Innovation by Evolution: Bringing New Chemistry to Life (Nobel Lecture)
Abstract
The directed evolution of enzymes is now routinely used to develop new catalysts with various applications, such as in environmentally friendly production of chemicals and renewable fuels. In her Nobel lecture, F. Arnold describes how lessons from nature inspired the development of methods for directed evolution.
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Citations
Cited by
Wackett, L. P., & Robinson, S. L. (2020) · Biochemical Journal · doi:10.1042/bcj20190720 · Cited by 71
Harnessing generative AI to decode enzyme catalysis and evolution for enhanced engineering
Xie, W. J., & Warshel, A. (2023) · National Science Review · doi:10.1093/nsr/nwad331 · Cited by 69
De novo design and evolution of an artificial metathase for cytoplasmic olefin metathesis
Zou, Z., Kalvet, I., Lozhkin, B., Morris, E., Zhang, K., Chen, D., Ernst, M. L., Zhang, X., Baker, D., & Ward, T. R. (2025) · Nature Catalysis · doi:10.1038/s41929-025-01436-0 · Cited by 30
Reconciling conformational heterogeneity and substrate recognition in cytochrome P450
Dandekar, B. R., Ahalawat, N., & Mondal, J. (2021) · Biophysical Journal · doi:10.1016/j.bpj.2021.02.040 · Cited by 14
Metadata
- Authors
- Arnold, F. H.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2019-08-21
- Volume
- 58
- Issue
- 41
- Pages
- 14420-14426
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2969819767
- Cited by
- 404
- References
- 0
- FWCI
- 15.54
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.