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A Smart, Autocatalytic, DNAzyme Biocircuit for in Vivo, Amplified, MicroRNA Imaging
Abstract
DNAzymes have been recognized as promising transducing agents for visualizing endogenous biomarkers, but their inefficient intracellular delivery and limited amplification capacity (including insufficient cofactor supply) preclude their extensive biological application. Herein, an autocatalytic DNAzyme (ACD) biocircuit is constructed for amplified microRNA imaging in vivo based on a hybridization chain reaction (HCR) and DNAzyme biocatalysis, sustained by a honeycomb MnO 2 nanosponge (hMNS). The hMNS not only delivers DNA probes, but also supplies Mn 2+ as a DNAzyme cofactor and magnetic resonance imaging (MRI) agent. Through the subsequent cross‐activation of HCR and DNAzyme amplicons, the ACD amplifies the limited signal resulting from miRNA recognition. The hMNS/ACD system was used to image microRNA in vivo, thus demonstrating its great promise in cancer diagnosis.
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Cites
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
Visualization of Single RNA Transcripts in Situ
Femino, A. M., Fay, F. S., Fogarty, K., & Singer, R. H. (1998) · Science · doi:10.1126/science.280.5363.585 · Cited by 1,504
Cited by
McConnell, E. M., Cozma, I., Mou, Q., Brennan, J. D., Lu, Y., & Li, Y. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00240f · Cited by 477
Metadata
- Authors
- Wei, J., Wang, H., Wu, Q., Gong, X., Ma, K., Liu, X., & Wang, F.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2020-02-21
- Volume
- 59
- Issue
- 15
- Pages
- 5965-5971
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3000919623
- Cited by
- 272
- References
- 2
- FWCI
- 10.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wei, J., Wang, H., Wu, Q., Gong, X., Ma, K., Liu, X., & Wang, F. (2020). A Smart, Autocatalytic, DNAzyme Biocircuit for in Vivo, Amplified, MicroRNA Imaging. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201911712
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