MicroRNAs: Target Recognition and Regulatory Functions

Untitled work

Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714 · see citing works

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948 · see citing works

Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets

Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855 · see citing works

Most mammalian mRNAs are conserved targets of microRNAs

Friedman, R. C., Farh, K. K.-H., Burge, C. B., & Bartel, D. P. (2009) · Genome Research · doi:10.1101/gr.082701.108 · Cited by 8,462 · see citing works

Untitled work

(2008) · doi:10.1038/nrg2290 · Cited by 5,199 · see citing works

The nuclear RNase III Drosha initiates microRNA processing

Lee, Y., Ahn, C., Han, J., Choi, H., Kim, J., Yim, J., Lee, J., Provost, P., Rådmark, O., Kim, S., et al. (2003) · Nature · doi:10.1038/nature01957 · Cited by 5,094 · see citing works

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

Reinhart, B. J., Slack, F. J., Basson, M., Pasquinelli, A. E., Bettinger, J. C., Rougvie, A. E., Horvitz, H. R., & Ruvkun, G. (2000) · Nature · doi:10.1038/35002607 · Cited by 4,989 · see citing works

Identification of Novel Genes Coding for Small Expressed RNAs

Lagos-Quintana, M., Rauhut, R., Lendeckel, W., & Tuschl, T. (2001) · Science · doi:10.1126/science.1064921 · Cited by 4,956 · see citing works

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., Castle, J., Bartel, D. P., Linsley, P. S., & Johnson, J. M. (2005) · Nature · doi:10.1038/nature03315 · Cited by 4,755 · see citing works

Combinatorial microRNA target predictions

Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603 · see citing works

miRBase: tools for microRNA genomics

Griffiths‐Jones, S., Saini, H. K., van Dongen, S., & Enright, A. J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm952 · Cited by 4,349 · see citing works

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292 · see citing works

Silencing of microRNAs in vivo with ‘antagomirs’

Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949 · see citing works

Human MicroRNA Targets

John, B., Enright, A. J., Aravin, A., Tuschl, T., Sander, C., & Marks, D. S. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020363 · Cited by 3,796 · see citing works

MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing

Grimson, A., Farh, K. K.-H., Johnston, W. K., Garrett-Engele, P., Lim, L. P., & Bartel, D. P. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.017 · Cited by 3,766 · see citing works

A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing

Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A. O., Landthaler, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.040 · Cited by 3,626 · see citing works

MicroRNA targets in Drosophila

Enright, A. J., John, B., Gaul, U., Tuschl, T., Sander, C., & Marks, D. S. (2003) · Genome Biology · doi:10.1186/gb-2003-5-1-r1 · Cited by 3,597 · see citing works

The impact of microRNAs on protein output

Baek, D., Villén, J., Shin, C., Camargo, F. D., Gygi, S. P., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07242 · Cited by 3,592 · see citing works

A microRNA polycistron as a potential human oncogene

He, L., Thomson, J. M., Hemann, M. T., Hernando, E., Mu, D., Goodson, S. G., Powers, S., Cordon‐Cardo, C., Lowe, S. W., Hannon, G. J., et al. (2005) · Nature · doi:10.1038/nature03552 · Cited by 3,520 · see citing works

Widespread changes in protein synthesis induced by microRNAs

Selbach, M., Schwanhäusser, B., Thierfelder, N., Fang, Z., Khanin, R., & Rajewsky, N. (2008) · Nature · doi:10.1038/nature07228 · Cited by 3,429 · cited 8× · see citing works

Switching from Repression to Activation: MicroRNAs Can Up-Regulate Translation

Vasudevan, S., Tong, Y., & STEITZ, J. A. (2007) · Science · doi:10.1126/science.1149460 · Cited by 2,806 · see citing works

MicroRNAs AND THEIR REGULATORY ROLES IN PLANTS

Jones-Rhoades, M. W., Bartel, D. P., & Bartel, B. (2006) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.57.032905.105218 · Cited by 2,668 · see citing works

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

Pasquinelli, A. E., Reinhart, B. J., Slack, F. J., Martindale, M. Q., Kuroda, M. I., Maller, B., Hayward, D. C., Ball, E. E., Degnan, B. M., Müller, P., et al. (2000) · Nature · doi:10.1038/35040556 · Cited by 2,568 · see citing works

The microRNA.org resource: targets and expression

Betel, D., Wilson, M. T., Gabow, A. P., Marks, D. S., & Sander, C. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm995 · Cited by 2,490 · see citing works

The role of site accessibility in microRNA target recognition

Kertesz, M., Iovino, N., Unnerstall, U., Gaul, U., & Segal, E. (2007) · Nature Genetics · doi:10.1038/ng2135 · Cited by 2,460 · see citing works

Principles of MicroRNA–Target Recognition

Brennecke, J., Stark, A., Russell, R. B., & Cohen, S. M. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030085 · Cited by 2,384 · see citing works

Prediction of Plant MicroRNA Targets

Jones-Rhoades, M. W., Reinhart, B. J., Lim, L. P., Burge, C. B., Bartel, B., & Bartel, D. P. (2002) · Cell · doi:10.1016/s0092-8674(02)00863-2 · Cited by 2,263 · see citing works

A pancreatic islet-specific microRNA regulates insulin secretion

Poy, M. N., Eliasson, L., Krutzfeldt, J., Kuwajima, S., Ma, X., MacDonald, P. E., Pfeffer, S., Tuschl, T., Rajewsky, N., Rorsman, P., et al. (2004) · Nature · doi:10.1038/nature03076 · Cited by 2,102 · see citing works

A microRNA in a Multiple-Turnover RNAi Enzyme Complex

Hutvágner, G., & Zamore, P. D. (2002) · Science · doi:10.1126/science.1073827 · Cited by 2,081 · see citing works

Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals

Xie, X., Lu, J., Kulbokas, E. J., Golub, T. R., Mootha, V., Lindblad-Toh, K., Lander, E. S., & Kellis, M. (2005) · Nature · doi:10.1038/nature03441 · Cited by 1,872 · see citing works

Requirement of <i>bic/microRNA-155</i> for Normal Immune Function

Rodriguez, A., Vigorito, E., Clare, S., Warren, M. V., Couttet, P., Soond, D. R., van Dongen, S., Grocock, R. J., Das, P. P., Miska, E. A., et al. (2007) · Science · doi:10.1126/science.1139253 · Cited by 1,833 · see citing works

MicroRNA-Directed Cleavage of <i>HOXB8</i> mRNA

Yekta, S., Shih, I.-H., & Bartel, D. P. (2004) · Science · doi:10.1126/science.1097434 · Cited by 1,702 · see citing works

Specificity of microRNA target selection in translational repressionPreprint

Doench, J. G., & Sharp, P. A. (2004) · Genes & Development · doi:10.1101/gad.1184404 · Cited by 1,642 · see citing works

Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis

Zhao, Y. B., Samal, E., & Srivastava, D. P. (2005) · Nature · doi:10.1038/nature03817 · Cited by 1,556 · see citing works

MicroRNA Expression in Zebrafish Embryonic Development

Wienholds, E., Kloosterman, W. P., Miska, E., Alvarez-Saavedra, E., Berezikov, E., de Bruijn, E., Horvitz, H. R., Kauppinen, S., & Plasterk, R. H. A. (2005) · Science · doi:10.1126/science.1114519 · Cited by 1,551 · see citing works

The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution

Farh, K. K.-H., Grimson, A., Jan, C., Lewis, B. P., Johnston, W. K., Lim, L. P., Burge, C. B., & Bartel, D. P. (2005) · Science · doi:10.1126/science.1121158 · Cited by 1,484 · see citing works

Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation

Lai, E. C. (2002) · Nature Genetics · doi:10.1038/ng865 · Cited by 1,478 · see citing works

Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity

Song, J., Smith, S. K., Hannon, G. J., & Joshua‐Tor, L. (2004) · Science · doi:10.1126/science.1102514 · Cited by 1,465 · see citing works

Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs

Bartel, D. P., & Chen, C. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1328 · Cited by 1,417 · see citing works

Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites

Sandberg, R., Neilson, J. R., Sarma, A., Sharp, P. A., & Burge, C. B. (2008) · Science · doi:10.1126/science.1155390 · Cited by 1,349 · see citing works

Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation

Bagga, S., Bracht, J. R., Hunter, S. E., Massirer, K. B., Holtz, J., Eachus, R., & Pasquinelli, A. E. (2005) · Cell · doi:10.1016/j.cell.2005.07.031 · Cited by 1,347 · see citing works

Relief of microRNA-Mediated Translational Repression in Human Cells Subjected to Stress

Bhattacharyya, S. N., Habermacher, R., Martiné, U., Closs, E. I., & Filipowicz, W. (2006) · Cell · doi:10.1016/j.cell.2006.04.031 · Cited by 1,332 · see citing works

siRNAs can function as miRNAsPreprint

Doench, J. G., Petersen, C. P., & Sharp, P. A. (2003) · Genes & Development · doi:10.1101/gad.1064703 · Cited by 1,262 · see citing works

A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep

Clop, A., Marcq, F., Takeda, H., Pirottin, D., Tordoir, X., Bibé, B., Bouix, J., Caiment, F., Elsen, J.-M., Eychenne, F., et al. (2006) · Nature Genetics · doi:10.1038/ng1810 · Cited by 1,260 · see citing works

Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR

Lytle, J., Yario, T. A., & STEITZ, J. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703820104 · Cited by 1,196 · see citing works

Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation

Mayr, C., Hemann, M. T., & Bartel, D. P. (2007) · Science · doi:10.1126/science.1137999 · Cited by 1,099 · see citing works

The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race

Aravin, A. A., Hannon, G. J., & Brennecke, J. (2007) · Science · doi:10.1126/science.1146484 · Cited by 1,096 · see citing works

Animal MicroRNAs Confer Robustness to Gene Expression and Have a Significant Impact on 3′UTR Evolution

Stark, A., Brennecke, J., Bushati, N., Russell, R. B., & Cohen, S. M. (2005) · Cell · doi:10.1016/j.cell.2005.11.023 · Cited by 1,080 · see citing works

MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb

Xiao, C., Calado, D. P., Galler, G. R., Thai, T., Patterson, H. C., Wang, J., Rajewsky, N., Bender, T. P., & Rajewsky, K. (2007) · Cell · doi:10.1016/j.cell.2007.07.021 · Cited by 1,041 · see citing works

The microRNAs of <i>Caenorhabditis elegans</i>

Lim, L. P., Lau, N. C., Weinstein, E. G., Abdelhakim, A., Yekta, S., Rhoades, M. W., Burge, C. B., & Bartel, D. P. (2003) · Genes &amp; Development · doi:10.1101/gad.1074403 · Cited by 1,007 · see citing works

Large-Scale Sequencing Reveals 21U-RNAs and Additional MicroRNAs and Endogenous siRNAs in C. elegans

Ruby, J. G., Jan, C. H., Player, C. M., Axtell, M. J., Lee, W., Nusbaum, C., Ge, H., & Bartel, D. P. (2006) · Cell · doi:10.1016/j.cell.2006.10.040 · Cited by 967 · see citing works

Sequence Variants in <i>SLITRK1</i> Are Associated with Tourette's Syndrome

Abelson, J. F., Kwan, K. Y., O'Roak, B. J., Baek, D. Y., Stillman, A. A., Morgan, T. M., Mathews, C. A., Pauls, D. L., Rašin, M.-R., Gunel, M., et al. (2005) · Science · doi:10.1126/science.1116502 · Cited by 940 · see citing works

Identification of Drosophila MicroRNA Targets

Stark, A., Brennecke, J., Russell, R. B., & Cohen, S. M. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000060 · Cited by 784 · see citing works

A combined computational-experimental approach predicts human microRNA targetsPreprint

Kiriakidou, M., Nelson, P. T., Kouranov, A., Fitziev, P., Bouyioukos, C., Mourelatos, Z., & Hatzigeorgiou, A. G. (2004) · Genes & Development · doi:10.1101/gad.1184704 · Cited by 774 · see citing works

A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans

Johnston, R. J., & Hobert, O. (2003) · Nature · doi:10.1038/nature02255 · Cited by 760 · see citing works

RNA-Binding Protein Dnd1 Inhibits MicroRNA Access to Target mRNA

Kedde, M., Strasser, M. J., Boldajipour, B. A., Vrielink, J. A. F. O., Slanchev, K., le Sage, C., Nagel, R., Voorhoeve, P. M., van Duijse, J., Ørom, U. A., et al. (2007) · Cell · doi:10.1016/j.cell.2007.11.034 · Cited by 733 · see citing works

MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5′ region

Mallory, A. C., Reinhart, B. J., Jones-Rhoades, M. W., Tang, G., Zamore, P. D., Barton, M. K., & Bartel, D. P. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600340 · Cited by 681 · see citing works

Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

Ma, J., Yuan, Y. A., Meister, G., Pei, Y., Tuschl, T., & Patel, D. J. (2005) · Nature · doi:10.1038/nature03514 · Cited by 649 · see citing works

Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures

Stark, A., Lin, M. F., Kheradpour, P., Pedersen, J. S., Parts, L., Carlson, J. W., Crosby, M. A., Rasmussen, M. D., Roy, S., Deoras, A. N., et al. (2007) · Nature · doi:10.1038/nature06340 · Cited by 632 · see citing works

Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAsPreprint

Ruby, J. G., Stark, E., Johnston, W. K., Kellis, M., Bartel, D. P., & Lai, E. C. (2007) · Genome Research · doi:10.1101/gr.6597907 · Cited by 591 · see citing works

Molecular Basis for Target RNA Recognition and Cleavage by Human RISC

Ameres, S. L., Martı̂nez, J., & Schroeder, R. (2007) · Cell · doi:10.1016/j.cell.2007.04.037 · Cited by 559 · see citing works

Cell-type-specific signatures of microRNAs on target mRNA expression

Sood, P., Krek, A., Zavolan, M., Macino, G., & Rajewsky, N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511045103 · Cited by 547 · see citing works

Structural insights into mRNA recognition from a PIWI domain–siRNA guide complex

Parker, J. S., Roe, S. M., & Barford, D. (2005) · Nature · doi:10.1038/nature03462 · Cited by 531 · see citing works

The UCSC Genome Browser Database: 2008 update

Karolchik, D., Kuhn, R. M., Baertsch, R., Barber, G. P., Clawson, H., Diekhans, M., Giardine, B. M., Harte, R., Hinrichs, A. S., Hsu, F., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm966 · Cited by 522 · see citing works

Target Protectors Reveal Dampening and Balancing of Nodal Agonist and Antagonist by miR-430

Choi, W.-Y., Giráldez, A. J., & Schier, A. F. (2007) · Science · doi:10.1126/science.1147535 · Cited by 517 · see citing works

Small RNAs Correspond to Centromere Heterochromatic Repeats

Reinhart, B. J., & Bartel, D. P. (2002) · Science · doi:10.1126/science.1077183 · Cited by 503 · see citing works

Most Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability

Miska, E. A., Alvarez-Saavedra, E., Abbott, A. L., Lau, N. C., Hellman, A. B., McGonagle, S. M., Bartel, D. P., Ambros, V. R., & Horvitz, H. R. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030215 · Cited by 484 · cited 3× · see citing works

The let-7 MicroRNA Family Members mir-48, mir-84, and mir-241 Function Together to Regulate Developmental Timing in Caenorhabditis elegans

Abbott, A. L., Alvarez-Saavedra, E., Miska, E. A., Lau, N. C., Bartel, D. P., Horvitz, H. R., & Ambros, V. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.07.009 · Cited by 467 · see citing works

MicroRNA-155 Suppresses Activation-Induced Cytidine Deaminase-Mediated Myc-Igh Translocation

Dorsett, Y., McBride, K. M., Janković, M., Gazumyan, A., Thai, T., Robbiani, D. F., Virgilio, M. D., Reina‐San‐Martin, B., Heidkamp, G. F., Schwickert, T. A., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.04.002 · Cited by 456 · see citing works

MicroRNA-155 Is a Negative Regulator of Activation-Induced Cytidine Deaminase

Teng, G., Hakimpour, P., Landgraf, P., Rice, A., Tuschl, T., Casellas, R. C., & Papavasiliou, F. N. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.015 · Cited by 446 · see citing works

microRNA Target Predictions across Seven Drosophila Species and Comparison to Mammalian Targets

Grün, D., Wang, Y.-L., Langenberger, D., Gunsalus, K. C., & Rajewsky, N. (2005) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0010013 · Cited by 442 · see citing works

The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3′UTRPreprint

Vella, M. C., Choi, E.-Y., Lin, S.-Y., Reinert, K. L., & Slack, F. J. (2004) · Genes & Development · doi:10.1101/gad.1165404 · Cited by 442 · see citing works

Potent effect of target structure on microRNA function

Long, D., Lee, R., Williams, P., Chan, C. Y., Ambros, V., & Ding, Y. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1226 · Cited by 422 · see citing works

A Genome-Wide Map of Conserved MicroRNA Targets in C. elegans

Lall, S., Grün, D., Krek, A., Chen, K., Wang, Y.-L., Dewey, C. N., Sood, P., Colombo, T., Bray, N., MacMenamin, P., et al. (2006) · Current Biology · doi:10.1016/j.cub.2006.01.050 · Cited by 421 · see citing works

Determinants of targeting by endogenous and exogenous microRNAs and siRNAs

Nielsen, C. B., Shomron, N., Sandberg, R., Hornstein, E., Kitzman, J. O., & Burge, C. B. (2007) · RNA · doi:10.1261/rna.768207 · Cited by 385 · see citing works

Distance constraints between microRNA target sites dictate efficacy and cooperativity

Sætrom, P., Heale, B. S. E., Snøve, O., Aagaard, L., Alluin, J. V., & Rossi, J. J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm133 · Cited by 377 · see citing works

Multiplex Detection of RNA Expression in Drosophila Embryos

Kosman, D., Mizutani, C. M., Lemons, D., Cox, W. G., McGinnis, W. J., & Bier, E. (2004) · Science · doi:10.1126/science.1099247 · Cited by 357 · see citing works

The Caenorhabditis elegans hunchback-like Gene lin-57/hbl-1 Controls Developmental Time and Is Regulated by MicroRNAs

Abrahante, J. E., Daul, A. L., Li, M., Volk, M. L., Tennessen, J. M., Miller, E. A., & Rougvie, A. E. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00127-8 · Cited by 354 · see citing works

A microRNA Mediates EGF Receptor Signaling and Promotes Photoreceptor Differentiation in the Drosophila Eye

Li, X., & Carthew, R. W. (2005) · Cell · doi:10.1016/j.cell.2005.10.040 · Cited by 351 · see citing works

RNAi-Mediated Allelic trans-Interaction at the Imprinted Rtl1/Peg11 Locus

Davis, E. E., Caiment, F., Tordoir, X., Cavaillé, J., Ferguson‐Smith, A. C., Cockett, N., Georges, M., & Charlier, C. (2005) · Current Biology · doi:10.1016/j.cub.2005.02.060 · Cited by 331 · see citing works

Inference of miRNA targets using evolutionary conservation and pathway analysis

Gaidatzis, D., van Nimwegen, E., Hausser, J., & Zavolan, M. (2007) · BMC Bioinformatics · doi:10.1186/1471-2105-8-69 · Cited by 324 · see citing works

A biochemical approach to identifying microRNA targets

Karginov, F. V., Conaco, C., Xuan, Z., Schmidt, B. H., Parker, J. S., Mandel, G., & Hannon, G. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709971104 · Cited by 302 · see citing works

Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAsPreprint

Lai, E. C., Tam, B., & Rubin, G. M. (2005) · Genes & Development · doi:10.1101/gad.1291905 · Cited by 295 · see citing works

The Conserved microRNA MiR-8 Tunes Atrophin Levels to Prevent Neurodegeneration in Drosophila

Karres, J. S., Hilgers, V., Carrera, I., Treisman, J. E., & Cohen, S. M. (2007) · Cell · doi:10.1016/j.cell.2007.09.020 · Cited by 278 · see citing works

MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision

Johnston, R. J., Chang, S., Etchberger, J. F., Ortiz, C. O., & Hobert, O. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505530102 · Cited by 276 · see citing works

Micro-RNA Regulation of the Mammalian lin-28 Gene during Neuronal Differentiation of Embryonal Carcinoma Cells

Wu, L., & Belasco, J. G. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.21.9198-9208.2005 · Cited by 263 · see citing works

Isolation of microRNA targets by miRNP immunopurification

Easow, G., Teleman, A. A., & Cohen, S. M. (2007) · RNA · doi:10.1261/rna.563707 · Cited by 252 · see citing works

Incorporating structure to predict microRNA targets

Robins, H. S., Li, Y., & Padgett, R. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500775102 · Cited by 244 · see citing works

Identification of human microRNA targets from isolated argonaute protein complexes

Beitzinger, M., Peters, L., Zhu, J. Y., Kremmer, E., & Meister, G. (2007) · RNA Biology · doi:10.4161/rna.4.2.4640 · Cited by 236 · see citing works

Substrate requirements for let-7 function in the developing zebrafish embryo

Kloosterman, W. P., Wienholds, E., Ketting, R. F., & Plasterk, R. H. A. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw173 · Cited by 223 · see citing works

Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development.Preprint

Wightman, B., Bürglin, T. R., Gatto, J., Arasu, P., & Ruvkun, G. (1991) · Genes & Development · doi:10.1101/gad.5.10.1813 · Cited by 210 · see citing works

Substrate requirements for let-7 function in the developing zebrafish embryo

Kloosterman, W. P. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh968 · Cited by 206 · see citing works

mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein–enriched transcripts

Hammell, M., Long, D., Zhang, L., Lee, A., Carmack, C. S., Han, M., Ding, Y., & Ambros, V. (2008) · Nature Methods · doi:10.1038/nmeth.1247 · Cited by 202 · see citing works

Cell cycle control of microRNA-mediated translation regulation

Vasudevan, S., Tong, Y., & STEITZ, J. A. (2008) · Cell Cycle · doi:10.4161/cc.7.11.6018 · Cited by 187 · see citing works

Molecular architecture of a miRNA-regulated 3′ UTR

Didiano, D., & Hobert, O. (2008) · RNA · doi:10.1261/rna.1082708 · Cited by 184 · see citing works

LIN-12/Notch Activation Leads to MicroRNA-Mediated Down-Regulation of Vav in C. elegans

Yoo, A. S., & Greenwald, I. (2005) · Science · doi:10.1126/science.1119481 · Cited by 167 · see citing works

Reliable prediction of regulator targets using 12 Drosophila genomesPreprint

Kheradpour, P., Stark, A., Roy, S., & Kellis, M. (2007) · Genome Research · doi:10.1101/gr.7090407 · Cited by 159 · see citing works

The K box, a conserved 3′ UTR sequence motif, negatively regulates accumulation of Enhancer of split Complex transcripts

Lai, E. C., Burks, C., & Posakony, J. W. (1998) · Development · doi:10.1242/dev.125.20.4077 · Cited by 157 · see citing works

The Bearded box, a novel 3′ UTR sequence motif, mediates negative post-transcriptional regulation of Bearded and Enhancer of split Complex gene expression

Lai, E. C., & Posakony, J. W. (1997) · Development · doi:10.1242/dev.124.23.4847 · Cited by 125 · see citing works

Spatial preferences of microRNA targets in 3' untranslated regions

Majoros, W. H., & Ohler, U. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-152 · Cited by 123 · see citing works

Denoising feedback loops by thresholding—a new role for microRNAs: Figure 1.Preprint

Cohen, S. M., Brennecke, J., & Stark, A. (2006) · Genes & Development · doi:10.1101/gad.1484606 · Cited by 92 · see citing works

Erratum to: Inference of miRNA targets using evolutionary conservation and pathway analysis

Gaidatzis, D., van Nimwegen, E., Hausser, J., et al. (2007) · BMC Bioinformatics · doi:10.1186/1471-2105-8-248 · Cited by 22 · see citing works

Untitled work

(2001) · doi:10.1126/science.1065329

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

Mourelatos, Z., Dostie, J., Paushkin, S., Sharma, A., Charroux, B., Abel, L., Rappsilber, J., Mann, M., & Dreyfuss, G. (2002) · Genes &amp; Development · doi:10.1101/gad.974702

Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs

Giraldez, A. J., Mishima, Y., Rihel, J., Grocock, R. J., Van Dongen, S., Inoue, K., Enright, A. J., & Schier, A. F. (2006) · Science · doi:10.1126/science.1122689

Untitled work

(2004) · doi:10.1038/nsmb780

The Cold Shock Domain Protein LIN-28 Controls Developmental Timing in C. elegans and Is Regulated by the lin-4 RNA

Moss, E. G., Lee, R. C., & Ambros, V. (1997) · Cell · doi:10.1016/s0092-8674(00)81906-6

Differential Regulation of Germline mRNAs in Soma and Germ Cells by Zebrafish miR-430

Mishima, Y., Giraldez, A. J., Takeda, Y., Fujiwara, T., Sakamoto, H., Schier, A. F., & Inoue, K. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.086

<i>MicroRNA-9a</i> ensures the precise specification of sensory organ precursors in <i>Drosophila</i>

Li, Y., Wang, F., Lee, J.-A., & Gao, F.-B. (2006) · Genes &amp; Development · doi:10.1101/gad.1466306

Untitled work

(2001) · doi:10.1016/s0092-8674(01)00431-7

Untitled work

(2003) · doi:10.1016/s0960-9822(03)00287-2

A Pattern-Based Method for the Identification of MicroRNA Binding Sites and Their Corresponding Heteroduplexes

Miranda, K. C., Huynh, T., Tay, Y., Ang, Y.-S., Tam, W.-L., Thomson, A. M., Lim, B., & Rigoutsos, I. (2006) · Cell · doi:10.1016/j.cell.2006.07.031

Untitled work

(2003) · doi:10.1016/s0092-8674(03)01018-3

Untitled work

(2001) · doi:10.1126/science.1065062

Natural RNA circles function as efficient microRNA sponges

Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985 · see citing works

Circular RNAs are a large class of animal RNAs with regulatory potency

Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990 · see citing works

Regulation of microRNA biogenesis

Ha, M., & Kim, V. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3838 · Cited by 5,462 · see citing works

The widespread regulation of microRNA biogenesis, function and decay

Krol, J., Loedige, I., & Filipowicz, W. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2843 · Cited by 4,672 · see citing works

Mammalian microRNAs predominantly act to decrease target mRNA levels

Guo, H., Ingolia, N. T., Weissman, J. S., & Bartel, D. P. (2010) · Nature · doi:10.1038/nature09267 · Cited by 3,886 · see citing works

Regulation of mRNA Translation and Stability by microRNAs

Fabian, M. R., Sonenberg, N., & Filipowicz, W. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060308-103103 · Cited by 3,214 · see citing works

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

Huntzinger, E., & Izaurralde, E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2936 · Cited by 2,339 · see citing works

Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy

Yu, T., Guo, F., Yu, Y., Sun, T., Ma, D., Han, J., Qian, Y., Kryczek, I., Sun, D., Nagarsheth, N., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.008 · Cited by 2,198 · see citing works

The functions and regulation of the PTEN tumour suppressor

Song, M. S., Salmena, L., & Pandolfi, P. P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3330 · Cited by 1,926 · see citing works

RNA-guided genetic silencing systems in bacteria and archaea

Wiedenheft, B., Sternberg, S. H., & Doudna, J. A. (2012) · Nature · doi:10.1038/nature10886 · Cited by 1,851 · see citing works

Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites

Betel, D., Koppal, A., Agius, P., Sander, C., & Leslie, C. (2010) · Genome Biology · doi:10.1186/gb-2010-11-8-r90 · Cited by 1,592 · see citing works

Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

Mayr, C., & Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.06.016 · Cited by 1,613 · see citing works

Adipose-derived circulating miRNAs regulate gene expression in other tissues

Thomou, T., Mori, M. A., Dreyfuss, J. M., Konishi, M., Sakaguchi, M., Wolfrum, C., Rao, T. N., Winnay, J. N., Garcia-Martin, R., Grinspoon, S. K., et al. (2017) · Nature · doi:10.1038/nature21365 · Cited by 1,539 · see citing works

Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy

Cartier, N., Hacein-Bey-Abina, S., Bartholomae, C. C., Veres, G., Schmidt, M., Kutschera, I., Vidaud, M., Abel, U., Dal-Cortivo, L., Caccavelli, L., et al. (2009) · Science · doi:10.1126/science.1171242 · Cited by 1,508 · see citing works

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

Ha, D., Yang, N., & Nadithe, V. (2016) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.02.001 · Cited by 1,346 · see citing works

The miR-34 family in cancer and apoptosis

Hermeking, H. (2010) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2009.56 · Cited by 1,236 · see citing works

Adipose tissue macrophage-derived exosomal miRNAs can modulate in vivo and in vitro insulin sensitivity

Ying, W., Riopel, M., Bandyopadhyay, G., Dong, Y., Birmingham, A., Seo, J. B., Ofrecio, J. M., Wollam, J., Hernandez-Carretero, A., Fu, W., et al. (2017) · Cell · doi:10.1016/j.cell.2017.08.035 · Cited by 1,191 · see citing works

Epigenetics and gene expression

Gibney, E. R., & Nolan, C. M. (2010) · Heredity · doi:10.1038/hdy.2010.54 · Cited by 1,109 · see citing works

Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity

You, X., Vlatkovic, I., Babic, A., Will, T., Epstein, I., Tushev, G., Akbalik, G., Wang, M., Glock, C., Quedenau, C., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3975 · Cited by 1,149 · see citing works

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis

Fong, M. Y., Zhou, W., Liu, L., Alontaga, A. Y., Chandra, M., Ashby, J., Chow, A., O’Connor, S. T. F., Li, S., Chin, A. R., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3094 · Cited by 1,118 · see citing works

Adipose Tissue in Obesity-Related Inflammation and Insulin Resistance: Cells, Cytokines, and Chemokines

Makki, K., Froguel, P., & Wolowczuk, I. (2013) · ISRN Inflammation · doi:10.1155/2013/139239 · Cited by 1,085 · see citing works

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age‐Related Diseases

Davalli, P., Mitic, T., Caporali, A., Lauriola, A., & D’Arca, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3565127 · Cited by 1,059 · see citing works

The microcosmos of cancer

Lujambio, A., & Lowe, S. W. (2012) · Nature · doi:10.1038/nature10888 · Cited by 1,084 · see citing works

siRNA versus miRNA as therapeutics for gene silencing

Lam, J. K. W., Chow, M. Y. T., Zhang, Y., & Leung, S. W. S. (2015) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2015.23 · Cited by 1,081 · see citing works

Functional screening identifies miRNAs inducing cardiac regeneration

Eulalio, A., Mano, M., Ferro, M. D., Zentilin, L., Sinagra, G., Zacchigna, S., & Giacca, M. (2012) · Nature · doi:10.1038/nature11739 · Cited by 1,029 · see citing works

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

Wu, X., Scott, D. A., Kriz, A. J., Chiu, A. C., Hsu, P. D., Dadon, D. B., Cheng, A. W., Trevino, A. E., Konermann, S., Chen, S., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.2889 · Cited by 944 · see citing works

MicroRNAs 103 and 107 regulate insulin sensitivity

Trajkovski, M., Hausser, J., Soutschek, J., Bhat, B., Akin, A., Zavolan, M., Heim, M. H., & Stoffel, M. (2011) · Nature · doi:10.1038/nature10112 · Cited by 1,000 · see citing works

A novel pathway regulates memory and plasticity via SIRT1 and miR-134

Gao, J., Wang, W.-Y., Mao, Y.-W., Gräff, J., Guan, J.-S., Pan, L., Mak, G., Kim, D., Su, S. C., & Tsai, L.-H. (2010) · Nature · doi:10.1038/nature09271 · Cited by 975 · see citing works

MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis

Najafi-Shoushtari, S. H., Kristo, F., Li, Y., Shioda, T., Cohen, D. E., Gerszten, R. E., & Näär, A. M. (2010) · Science · doi:10.1126/science.1189123 · Cited by 957 · see citing works

Beyond GWASs: Illuminating the Dark Road from Association to Function

Edwards, S. L., Beesley, J., French, J. D., & Dunning, A. M. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.10.012 · Cited by 784 · see citing works

NLRP3 inflammasome and its inhibitors: a review

Shao, B.-Z., Xu, Z.-Q., Han, B.-Z., Su, D.-F., & Liu, C. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00262 · Cited by 836 · see citing works

CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer

Hu, J. L., Wang, W., Lan, X. L., Zeng, Z. C., Liang, Y. S., Yan, Y. R., Song, F. Y., Wang, F. F., Zhu, X. H., Liao, W. J., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1019-x · Cited by 773 · see citing works

The host shapes the gut microbiota via fecal microRNA

Liu, S., da Cunha, A. P., Rezende, R. M., Cialic, R., Wei, Z., Bry, L., Comstock, L. E., Gandhi, R., & Weiner, H. L. (2016) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2015.12.005 · Cited by 808 · see citing works

Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor

Enuka, Y., Lauriola, M., Feldman, M. E., Sas-Chen, A., Ulitsky, I., & Yarden, Y. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1367 · Cited by 757 · see citing works

Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish

Bazzini, A. A., Lee, M. T., & Giraldez, A. J. (2012) · Science · doi:10.1126/science.1215704 · Cited by 709 · see citing works

Poly(A)-tail profiling reveals an embryonic switch in translational control

Subtelny, A. O., Eichhorn, S. W., Chen, G. R., Sive, H., & Bartel, D. P. (2014) · Nature · doi:10.1038/nature13007 · Cited by 664 · see citing works

miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling

Dávalos, A., Goedeke, L., Smibert, P., Ramírez, C. M., Warrier, N. P., Andreo, U., Cirera-Salinas, D., Rayner, K., Suresh, U., Pastor-Pareja, J. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102281108 · Cited by 670 · see citing works

Neural tissue engineering options for peripheral nerve regeneration

Gu, X., Ding, F., & Williams, D. F. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.04.064 · Cited by 630 · see citing works

Thiol-linked alkylation for the metabolic sequencing of RNA

Herzog, V. A., Reichholf, B., Neumann, T., Rescheneder, P., Bhat, P., Burkard, T. R., Wlotzka, W., von Haeseler, A., Zuber, J., & Ameres, S. L. (2017) · doi:10.1101/177642 · Cited by 622 · see citing works

The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy

Ucar, A., Gupta, S. K., Fiedler, J., Erikci, E., Kardasinski, M., Batkai, S., Dangwal, S., Kumarswamy, R., Bang, C., Holzmann, A., et al. (2012) · Nature Communications · doi:10.1038/ncomms2090 · Cited by 610 · see citing works

Regulation by 3′-Untranslated Regions

Mayr, C. (2017) · Annual Review of Genetics · doi:10.1146/annurev-genet-120116-024704 · Cited by 588 · see citing works

Landscape and variation of RNA secondary structure across the human transcriptome

Wan, Y., Qu, K., Zhang, Q. C., Flynn, R. A., Manor, O., Ouyang, Z., Zhang, J., Spitale, R. C., Snyder, M. P., Segal, E., et al. (2014) · Nature · doi:10.1038/nature12946 · Cited by 555 · see citing works

Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits

Xue, Y., Ouyang, K., Huang, J., Zhou, Y., Ouyang, H., Li, H., Wang, G., Wu, Q., Wei, C., Bi, Y., et al. (2013) · Cell · doi:10.1016/j.cell.2012.11.045 · Cited by 562 · see citing works

Identifying miRNAs, targets and functions

Liu, B., Li, J., & Cairns, M. J. (2014) · Briefings in Bioinformatics · doi:10.1093/bib/bbs075 · Cited by 563 · see citing works

miR-33 links SREBP-2 induction to repression of sterol transporters

Marquart, T. J., Allen, R. M., Ory, D. S., & Baldán, Á. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005191107 · Cited by 562 · see citing works

MicroRNAs in the p53 network: micromanagement of tumour suppression

Hermeking, H. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3318 · Cited by 518 · see citing works

Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression

Pu, M., Chen, J., Tao, Z., Miao, L., Qi, X., Wang, Y., & Ren, J. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2940-7 · Cited by 500 · see citing works

Pairing beyond the Seed Supports MicroRNA Targeting Specificity

Broughton, J. P., Lovci, M. T., Huang, J. L., Yeo, G. W., & Pasquinelli, A. E. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.09.004 · Cited by 487 · see citing works

METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation

Pandolfini, L., Barbieri, I., Bannister, A. J., Hendrick, A., Andrews, B., Webster, N., Murat, P., Mach, P., Brandi, R., Robson, S. C., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.03.040 · Cited by 491 · see citing works

Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders

Parikshak, N. N., Gandal, M. J., & Geschwind, D. H. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3934 · Cited by 430 · see citing works

MiR-16 Targets the Serotonin Transporter: A New Facet for Adaptive Responses to Antidepressants

Baudry, A., Mouillet-Richard, S., Schneider, B., Launay, J.-M., & Kellermann, O. (2010) · Science · doi:10.1126/science.1193692 · Cited by 480 · see citing works

A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response

Adamson, B., Smogorzewska, A., Sigoillot, F. D., King, R. W., & Elledge, S. J. (2012) · Nature Cell Biology · doi:10.1038/ncb2426 · Cited by 433 · see citing works

Gene co-expression network analysis reveals common system-level properties of prognostic genes across cancer types

Yang, Y., Han, L., Yuan, Y., Li, J., Hei, N., & Liang, H. (2014) · Nature Communications · doi:10.1038/ncomms4231 · Cited by 423 · see citing works

Epigenetic Regulation in Plants

Pikaard, C. S., & Mittelsten Scheid, O. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019315 · Cited by 440 · see citing works

HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells

Tabet, F., Vickers, K. C., Cuesta Torres, L. F., Wiese, C. B., Shoucri, B. M., Lambert, G., Catherinet, C., Prado-Lourenco, L., Levin, M. G., Thacker, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms4292 · Cited by 428 · see citing works

A Consideration of Biomarkers to be Used for Evaluation of Inflammation in Human Nutritional Studies

Calder, P. C., Ahluwalia, N., Albers, R., Bosco, N., Bourdet-Sicard, R., Haller, D., Holgate, S. T., Jönsson, L. S., Latulippe, M. E., Marcos, A., et al. (2013) · British Journal of Nutrition · doi:10.1017/s0007114512005119 · Cited by 425 · see citing works

Interplay between miRNAs and human diseases

Paul, P., Chakraborty, A., Sarkar, D., Langthasa, M., Rahman, M., Bari, M., Singha, R. S., Malakar, A. K., & Chakraborty, S. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25854 · Cited by 420 · see citing works

microRNA miR-27b impairs human adipocyte differentiation and targets PPARγ

Karbiener, M., Fischer, C., Nowitsch, S., Opriessnig, P., Papak, C., Ailhaud, G., Dani, C., Amri, E.-Z., & Scheideler, M. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.09.098 · Cited by 409 · see citing works

Characterization of Small RNAs in Aplysia Reveals a Role for miR-124 in Constraining Synaptic Plasticity through CREB

Rajasethupathy, P., Fiumara, F., Sheridan, R., Betel, D., Puthanveettil, S. V., Russo, J. J., Sander, C., Tuschl, T., & Kandel, E. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.029 · Cited by 406 · see citing works

Mechanisms and Regulation of Cellular Senescence

Roger, L., Tomas, F., & Gire, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313173 · Cited by 395 · see citing works

Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs

Londin, E., Loher, P., Telonis, A. G., Quann, K., Clark, P., Jing, Y., Hatzimichael, E., Kirino, Y., Honda, S., Lally, M., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1420955112 · Cited by 404 · see citing works

Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation*

Gerin, I., Clerbaux, L.-A., Haumont, O., Lanthier, N., Das, A. K., Burant, C. F., Leclercq, I. A., MacDougald, O. A., & Bommer, G. T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152090 · Cited by 382 · see citing works

Trials and Tribulations of MicroRNA Therapeutics

Seyhan, A. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031469 · Cited by 381 · see citing works

microRNA Expression Patterns Reveal Differential Expression of Target Genes with Age

Noren Hooten, N., Abdelmohsen, K., Gorospe, M., Ejiogu, N., Zonderman, A. B., & Evans, M. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010724 · Cited by 357 · see citing works

The role of the 3' untranslated region in post-transcriptional regulation of protein expression in mammalian cells.

Matoulkova, E., Michalova, E., Vojtesek, B., & Hrstka, R. (2012) · RNA Biology · doi:10.4161/rna.20231 · Cited by 357 · see citing works

Early Prenatal Stress Epigenetically Programs Dysmasculinization in Second-Generation Offspring via the Paternal Lineage

Morgan, C. P., & Bale, T. L. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1887-11.2011 · Cited by 346 · see citing works

Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer

Mori, M., Triboulet, R., Mohseni, M., Schlegelmilch, K., Shrestha, K., Camargo, F. D., & Gregory, R. I. (2014) · Cell · doi:10.1016/j.cell.2013.12.043 · Cited by 335 · see citing works

MicroRNAs and their isomiRs function cooperatively to target common biological pathways

Cloonan, N., Wani, S., Xu, Q., Gu, J., Lea, K., Heater, S., Barbacioru, C., Steptoe, A. L., Martin, H. C., Nourbakhsh, E., et al. (2011) · Genome Biology · doi:10.1186/gb-2011-12-12-r126 · Cited by 345 · see citing works

MicroRNA-210 Regulates Mitochondrial Free Radical Response to Hypoxia and Krebs Cycle in Cancer Cells by Targeting Iron Sulfur Cluster Protein ISCU

Favaro, E., Ramachandran, A., McCormick, R., Gee, H., Blancher, C., Crosby, M., Devlin, C., Blick, C., Buffa, F., Li, J.-L., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010345 · Cited by 324 · see citing works

Impact of MicroRNA levels, target-site complementarity, and cooperativity on competing endogenous RNA-regulated gene expression

Denzler, R., McGeary, S. E., Title, A. C., Agarwal, V., Bartel, D. P., & Stoffel, M. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.09.027 · Cited by 340 · see citing works

An alternative mode of microRNA target recognition

Chi, S. W., Hannon, G. J., & Darnell, R. B. (2012) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb.2230 · Cited by 328 · see citing works

miRNA–target chimeras reveal miRNA 3′-end pairing as a major determinant of Argonaute target specificity

Moore, M. J., Scheel, T. K. H., Luna, J. M., Park, C. Y., Fak, J. J., Nishiuchi, E., Rice, C. M., & Darnell, R. B. (2015) · Nature Communications · doi:10.1038/ncomms9864 · Cited by 326 · see citing works

MicroRNA Expression Is Down-Regulated and Reorganized in Prefrontal Cortex of Depressed Suicide Subjects

Smalheiser, N. R., Lugli, G., Rizavi, H. S., Torvik, V. I., Turecki, G., & Dwivedi, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033201 · Cited by 324 · see citing works

Aging alters tissue resident mesenchymal stem cell properties

Alt, E. U., Senst, C., Murthy, S. N., Slakey, D. P., Dupin, C. L., Chaffin, A. E., Kadowitz, P. J., & Izadpanah, R. (2012) · Stem Cell Research · doi:10.1016/j.scr.2011.11.002 · Cited by 316 · see citing works

Modern Trends for Peripheral Nerve Repair and Regeneration: Beyond the Hollow Nerve Guidance Conduit

Carvalho, C. R., Oliveira, J. M., & Reis, R. L. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00337 · Cited by 297 · see citing works

miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target

Serocki, M., Bartoszewska, S., Janaszak-Jasiecka, A., Ochocka, R. J., Collawn, J. F., & Bartoszewski, R. (2018) · Angiogenesis · doi:10.1007/s10456-018-9600-2 · Cited by 288 · see citing works

Genomic views of STAT function in CD4+ T helper cell differentiation

O'Shea, J. J., Lahesmaa, R., Vahedi, G., Laurence, A., & Kanno, Y. (2011) · Nature Reviews Immunology · doi:10.1038/nri2958 · Cited by 295 · see citing works

MicroRNAs in resolution of acute inflammation: identification of novel resolvin Dl‐miRNA circuits

Recchiuti, A., Krishnamoorthy, S., Fredman, G., Chiang, N., & Serhan, C. N. (2011) · The FASEB Journal · doi:10.1096/fj.10-169599 · Cited by 292 · see citing works

Epigenetic Mechanisms of Depression and Antidepressant Action

Vialou, V., Feng, J., Robison, A. J., & Nestler, E. J. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134540 · Cited by 277 · see citing works

miRNAs control insulin content in pancreatic β‐cells via downregulation of transcriptional repressors

Melkman‐Zehavi, T., Oren, R., Kredo‐Russo, S., Shapira, T., Mandelbaum, A. D., Rivkin, N., Nir, T., Lennox, K. A., Behlke, M. A., Dor, Y., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.361 · Cited by 280 · see citing works

Resolvin D1 Receptor Stereoselectivity and Regulation of Inflammation and Proresolving MicroRNAs

Krishnamoorthy, S., Recchiuti, A., Chiang, N., Fredman, G., & Serhan, C. N. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.01.028 · Cited by 283 · see citing works

RNAi and small interfering RNAs in human disease therapeutic applications

Lares, M. R., Rossi, J. J., & Ouellet, D. L. (2010) · Trends in biotechnology · doi:10.1016/j.tibtech.2010.07.009 · Cited by 277 · see citing works

Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis

Moore, M. J., Zhang, C., Gantman, E. C., Mele, A., Darnell, J. C., & Darnell, R. B. (2014) · Nature Protocols · doi:10.1038/nprot.2014.012 · Cited by 251 · see citing works

MicroRNAs shape the neuronal landscape

McNeill, E., & Van Vactor, D. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.005 · Cited by 274 · see citing works

MirSNP, a database of polymorphisms altering miRNA target sites, identifies miRNA-related SNPs in GWAS SNPs and eQTLs

Liu, C., Zhang, F., Li, T., Lu, M., Wang, L., Yue, W., & Zhang, D. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-661 · Cited by 264 · see citing works

Tumor-Induced Osteoclast miRNA Changes as Regulators and Biomarkers of Osteolytic Bone Metastasis

Ell, B., Mercatali, L., Ibrahim, T., Campbell, N., Schwarzenbach, H., Pantel, K., Amadori, D., & Kang, Y. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.09.008 · Cited by 266 · see citing works

Epigenetics and depression

Penner-Goeke, S., & Binder, E. B. (2019) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2019.21.4/ebinder · Cited by 254 · see citing works

Cytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes

Lee, J.-A., Damianov, A., Lin, C.-H., Fontes, M., Parikshak, N. N., Anderson, E. S., Geschwind, D. H., Black, D. L., & Martin, K. C. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.025 · Cited by 232 · see citing works

MicroRNAs in Metabolic Disease

Fernández-Hernando, C., Ramírez, C. M., Goedeke, L., & Suárez, Y. (2013) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.112.300144 · Cited by 257 · see citing works

The epigenetic landscape related to reactive oxygen species formation in the cardiovascular system

Kietzmann, T., Petry, A., Shvetsova, A., Gerhold, J. M., & Görlach, A. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13792 · Cited by 253 · see citing works

microRNA as Repressors of Stress-Induced Anxiety: The Case of Amygdalar miR-34

Haramati, S., Navon, I., Issler, O., Ezra-Nevo, G., Gil, S., Zwang, R., Hornstein, E., & Chen, A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1673-11.2011 · Cited by 252 · see citing works

Endometriosis and nuclear receptors

Yilmaz, B. D., & Bulun, S. E. (2019) · Human Reproduction Update · doi:10.1093/humupd/dmz005 · Cited by 243 · see citing works

Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes

Jovičić, A., Roshan, R., Moisoi, N., Pradervand, S., Moser, R., Pillai, B., & Luthi-Carter, R. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0600-12.2013 · Cited by 251 · see citing works

The regulation of mRNA stability in mammalian cells: 2.0

Wu, X., & Brewer, G. (2012) · Gene · doi:10.1016/j.gene.2012.03.021 · Cited by 239 · see citing works

MicroRNAs: New Regulators of Toll-Like Receptor Signalling Pathways

He, X., Jing, Z., & Cheng, G. (2014) · BioMed Research International · doi:10.1155/2014/945169 · Cited by 238 · see citing works

MIR-210 modulates mitochondrial respiration in placenta with preeclampsia

Muralimanoharan, S., Maloyan, A., Mele, J., Guo, C., Myatt, L. G., & Myatt, L. (2012) · Placenta · doi:10.1016/j.placenta.2012.07.002 · Cited by 237 · see citing works

An epigenetic framework for neurodevelopmental disorders: From pathogenesis to potential therapy

Millan, M. J. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.11.015 · Cited by 229 · see citing works

Glutamatergic model psychoses: prediction error, learning, and inference

Corlett, P. R., Honey, G. D., Krystal, J. H., & Fletcher, P. C. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.163 · Cited by 229 · see citing works

Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression

Fan, C., Li, Y., Lan, T., Wang, W., Long, Y., & Yu, S. Y. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2021.11.006 · Cited by 227 · see citing works

Control of Cholesterol Metabolism and Plasma High-Density Lipoprotein Levels by microRNA-144

Ramírez, C. M., Rotllan, N., Vlassov, A. V., Dávalos, A., Li, M., Goedeke, L., Aranda, J. F., Cirera-Salinas, D., Araldi, E., Salerno, A., et al. (2013) · Circulation Research · doi:10.1161/circresaha.112.300626 · Cited by 217 · see citing works

ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ

Атабекова, Б. Б. (2024) · Habaršy. Pedagogika ġylymdary seriâsy · doi:10.51889/2959-5762.2023.80.4.019

MicroRNA-21 versus microRNA-34: Lung cancer promoting and inhibitory microRNAs analysed in silico and in vitro and their clinical impact

Kunz, M., Göttlich, C., Walles, T., Nietzer, S., Dandekar, G., & Dandekar, T. (2017) · Tumor Biology · doi:10.1177/1010428317706430 · Cited by 23 · see citing works

MicroRNA-34, microRNA-130, microRNA-148, microRNA-181, microRNA-194 and microRNA-605 expression in colon cancer tissue

Игоревич, А. Д., Afanasyev, S. G., Avgustinovich, A. V., Спирина, Л. В., Ковалева, И. В., Zinnurova, A. B., & Belova, V. A. (2024) · South Russian Journal of Cancer · doi:10.37748/2686-9039-2024-5-1-2

MicroRNA Abnormalities and Their Roles in Lung Cancers

Osada, H. (2009) · Haigan · doi:10.2482/haigan.49.894

Therapeutic modulation of microRNAs

Chau, B., Esau, C. C., Mackenna, D., Neben, S., & Gibson, N. W. (2013) · Drug Discovery Today Therapeutic Strategies · doi:10.1016/j.ddstr.2013.12.002 · Cited by 2 · see citing works